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» LymeNet Flash » Questions and Discussion » Medical Questions » R.S.V.P. (Page 2)

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Author Topic: R.S.V.P.
Member # 12715

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Originally posted by Marnie:

Anyway...when we "fight" a disease, our adrenal glands kick in to defend us. This disrupts the HPA axis. The adrenal glands signal the hypothalamus and pituitary to alter their hormone production. There is a supp. that supposedly corrects this axis. PhosphatidylSerine.

Marnie, I am new to this list, but unfortunately not at all new to Lyme and its coinfections. I am still wading through this info and trying to digest it, but I was struck by point about PhosphatidylSerine. It is one of the "core supplements" used in Amy Lasko's protocol. Here is a cut and paste from an article written by Richard Van Konynenburg who is a researcher who has been working on a simplified version of Lasko's protocol for CFS/ME:
"1/4 tablet (200 micrograms) Folapro (Folapro is 5-methyl tetrahydrofolate, an active form of folate, which is sold by Metagenics with a license from Merck, which holds the patent on synthesis).

1/4 tablet Intrinsic B12/folate (This includes 200 micrograms of folate as a combination of folic acid, 5-methyl tetrahydrofolate, and 5-formyl tetrahydrofolate, aka folinic acid or leucovorin (another active form of folate), 125 micrograms of vitamin B12 as cyanocobalamin, 22.5 milligrams of calcium, 17.25 milligrams of phosphorus, and 5 milligrams of intrinsic factor)

(up to) 2 tablets (It's best to start with 1/4 tablet and work up as tolerated) Complete vitamin and ultra-antioxidant from Holistic Health Consultants (This is a multivitamin, multimineral supplement with some additional ingredients. It does not contain iron or copper, and it has a high ratio of magnesium to calcium. It contains antioxidants, some trimethylglycine, some nucleotides, and several supplements to support the sulfur metabolism.)

1 softgel capsule Phosphatidyl Serine Complex (This includes the phospholipids and some fatty acids)

1 sublingual lozenge Perque B12 (2,000 micrograms hydroxocobalamin with some mannitol, sucanat, magnesium and cherry extract)
[ Optional:]
1 capsule SAMe (200 mg S-adenosylmethionine)

1/3 dropper, 2X/day Methylation Support Nutriswitch Formula (This is an RNA mixture designed to help the methylation cycle. It is not essential, but is reported to be helpful.)

January 25, 2007

Suggestions for Treatment of Chronic Fatigue Syndrome (CFS) based on the Glutathione Depletion--Methylation Cycle Block Hypothesis for the Pathogenesis of CFS

Richard A. Van Konynenburg, Ph.D.

(Independent Researcher and Consultant"

The Phosphatidyl Serine is marketd under the name "Seriphos". THIS IS NOT A PROTOCOL YOU SHOULD TRY ON YOUR OWN as there have been some severe reactions. This protocol is directed towards breaking a block in the methylation cycle of NO synthesis. In my (very limited!) understanding I believe this is mostly closely linked to the function of macrophages in the immune system, and I was wondering if you could direct me to any information on their (dis)function in lyme patients. I belive Rivka here is considering this protocol, but I wondered what you thought of it, how much you knew about it because in some ways it seems to be in congruence with your own thoughts.

"A woman is like a tea bag- you never know how strong she is until she gets in hot water." Eleanor Roosevelt

Posts: 63 | From Jim Thorpe, PA | Registered: Aug 2007  |  IP: Logged | Report this post to a Moderator
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Do you know if the Seromycin is considered to have any effect on Bb? We are going to LLMD in about a week and will ask her about it.

Dd has been on IV abx for 19 months with limited success. She has severe anxiety attacks and also has had past tb exposure. Seems like a dream come true to us if it is an option for fighting Bb. Any additional info you could share would be most appreciated!


Posts: 260 | From Virginia | Registered: Jul 2004  |  IP: Logged | Report this post to a Moderator
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My LLMD did a vitamin/amino acid study and I was extremely deficient in Vitamin D and Serine. Do these low levels fit in with your theory?

He wants me to take 5000 mg a day of Vit D but didn't say anything about how to address the Serine issue.

I too am really trying to understand, it's just a little above my lyme brain right now.

Any suggestions would be welcome.

Posts: 237 | From WV | Registered: Mar 2007  |  IP: Logged | Report this post to a Moderator
Frequent Contributor (5K+ posts)
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See my post today (Pellegra) and watch closely as to WHY serine might be low.
Posts: 9402 | From Sunshine State | Registered: Mar 2001  |  IP: Logged | Report this post to a Moderator
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