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» LymeNet Flash » Questions and Discussion » Medical Questions » Mepron and fat intake - How much is enough?

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Author Topic: Mepron and fat intake - How much is enough?
Chia Pet
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Sorry if this has been discussed before.

I did a search and could not find a thread discussing how much fat to intake to insure Mepron absorption.

I am going to switch to Mepron instead of Malarone.

I took Mepron about 5 years ago and recall my LLMD telling me to take with cheese.

Is this sufficient? I don't want to overdo the fat intake since I already have issues with cholesteral.

But want to make sure I absorb the Mepron to it's maximum capacity short of sticking my face in a can of lard.

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KS
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I'm on Mepron as well and had the same questions. My doctor said to not even waste my money taking it if I didn't eat a very fatty meal.

I looked up a clinical study the manufacturer performed in order to evaluate absorbtion, etc. If I recall, it was something like 25-30g of fat.

Needless to say, I've put a few pounds on....nice excuse to eat a couple of donuts in the morning and a bowl of ice cream at night.

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Beverly
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My son and I took about 20-25 grams of fat with it.
My son would eat a hot dog and a glass of milk or 1/12 tablespoons of cream cheese with a glass of milk or hash browns and eggs with couple tablespoons butter.

I would eat a peanut butter on a rice cake with milk or yogurt.

good luck.. [Wink]

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groovy2
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Hi All

This is what I do -

I get a scoop of butter and let it
melt in my mouth-
then with the butter still in my mouth
I put the dose of mepron in my mouth
and swish the two together for a while-
then swallow--

You can use salad oil - cream cheese-

A few pieces of bacon or sausage worked
the best for me -

I chew up and mix the mepron in my mouth
real well and then swallow -

The mepron will have a real medicine taste
if you do this way -- Jay --

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Faith6
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I started taking mepron 2 weeks ago. I am on a dairy/gluten/egg/peanut/almond/beef/pork/sugar free diet so it's hard to know what to take it with. I'm now taking it with a fish oil capsule but I don't know if that is right. Anyone know or have other ideas?

--------------------
"His faithful love endures forever." Psalm 136

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hcconn22
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My LLMD said ten grams of fat.

--------------------
Positive 10 bands WB IGG & IGM
+ Babesia + Bartonolla and NOW RMSF 3/5/09 all at Quest

And still positive ELISA and WB two years after IV treatment
http://www.lymefriends.org/profile/blake

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WildCondor
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Have a good fat like avocado or olive oil with it. [Smile]
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Chia Pet
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Thanks for the responses.

I found a web site that has a detailed fat content by teaspoon for different fatty foods.
It says 1 tsp = 4 grams of fat.

It says one cup of low fat 2 % cottage cheese=
1 tsp = 4 grams fat.

Here is the fat content link.
http://www.canr.uconn.edu/nusci/outrch/pdf/HowMuchFat.pdf

[ 17. January 2008, 08:07 PM: Message edited by: Chia Pet ]

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Faith6
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Is it 25-30 grams or milligrams needed with mepron?

--------------------
"His faithful love endures forever." Psalm 136

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Chia Pet
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quote:
Originally posted by hcconn22:
My LLMD said ten grams of fat.

Oh lordy. Missed this post. Seems to be a discrepancy between what we all are being told.

10 grams is quite a bit less than 25-30 grams!

can anyone find the study discussed above online? I will try as well.

I suppose it can't hurt to eat some ice cream to be on the safe side in addition to a meal, that is if you can get some exercise later as one starts to feel better.

There goes my 15 lb weight loss, the only benefit to having babs. [Wink]

[ 17. January 2008, 10:50 PM: Message edited by: Chia Pet ]

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Chia Pet
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quote:
Originally posted by Faith6:
Is it 25-30 grams or milligrams needed with mepron?

Sorry, I read KS post wrong. Grams was posted and I put milligrams. I will edit my post.
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Beverly
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Personally I believe that milk fat and butter fat and even beef fat is a good fat. [Wink]
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Chia Pet
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quote:
Originally posted by Beverly:
Personally I believe that milk fat and butter fat and even beef fat is a good fat. [Wink]

Amen. [Big Grin]
I did find a study, albeit old though 1995, that said adding Flax oil or fish oil helped as well.
The Mepron available now I believe has better absorption.

Here's an excerpt from a Mepron info web page:
http://www.drugs.com/pro/mepron-tablets.html
_________________________________________________
The bioavailability of Mepron is increased approximately 3-fold when administered with meals.
In particular, fat has been shown to enhance absorption significantly.

In one study, 18 volunteers received a single dose of 500 mg Mepron after an overnight fast and following a breakfast (23 g fat: 642 kCal). The mean (SD) AUC values were 93.845.7 and 28877 hr μg/mL, under fasting and fed conditions, respectively.

In another volunteer study where Mepron was administered under fasting conditions, with 28 g butter (23 g fat) and 56 g butter (46 g fat) on toast, mean AUC values increased 2.7- and 4.0-fold, respectively, compared to the fasting state.
_______________________________________________

Now I am totally confused. [Roll Eyes]

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Keebler
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-

a good quality (organic) Coconut oil might be easier than coconut milk.

they add water to most coconut milks . . . and it gets expensive.

Fish oils ( and sardines), other health oils mentioned here, too (organic or dairy) real butter, olive oils, nut oils, but not artificial oils or hexane processed oils. not margarines, etc. nothing hydrogzinated - sp?).

Yes, even beef fat has some benefits such as CLA - conjugated linoleic acid. If possible, from grass-fed cattle. If not, try to get from a good source.

-

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