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» LymeNet Flash » Questions and Discussion » Medical Questions » To Niek and others about far infrared 880nM

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Author Topic: To Niek and others about far infrared 880nM
Marnie
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Besides the following, I have files on cytochrome C, COX-1 and COX-2, HO-1...

Niek...are you aware of this?

http://clinicaltrials.gov/search/open/intervention=radiotherapy

As a scientist, I'm sure you know also that the 880nM wavelength (energy) is absorbed by phosphate.

Furthermore, recombinant HS1 binds directly to Arp2/3 complex with an equilibrium dissociation constant (K(d)) of 880 nM. [2003]

HS1 (haematopoietic lineage cell-specific gene protein 1), a prominent substrate of intracellular protein tyrosine kinases in haematopoietic cells, is implicated in the immune response to extracellular stimuli and in cell differentiation induced by cytokines.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1223309
or
http://cat.inist.fr/?aModele=afficheN&cpsidt=14713301

Further experiments revealed that Wiskott-Aldrich Syndrome protein and Arp2/3 complex, major regulators of actin polymerization, are also recruited to these sites of actin accumulation.

In addition, inhibition of an upstream regulator of Wiskott-Aldrich Syndrome protein, the Rho-family GTPase CDC42Hs, greatly inhibited the occurrence of borrelia-induced phagocytic uptake structures.

Inhibition of Rac1, another Rho family GTPase, had a less-pronounced inhibitory effect, while blocking of Rho activity showed no discernible influence.

These results suggest that basic mechanisms of actin polymerization that control other types of phagocytosis are also functional in the formation of the morphologically unique uptake structures in coiling phagocytosis.

Our findings should enhance the understanding of the infection process of B. burgdorferi and contribute to devising new strategies for countering Lyme disease.

PMID: 11179351

In addition to phosphate absorption by the 880nM wavelength:

"A novel, two-photon probe for the detection of free Mg2+ ions in living cells and live tissues has been developed. The probe can be excited by 880 nm laser photons, emits strong two-photon excited fluorescence in response to Mg2+ ions, can be easily loaded into the cell and tissue, shows high photostability, and can measure the Mg2+ ion concentration without interference by Ca2+ ions in living cells. The intracellular dissociation constant (Kdi) for Mg2+ determined by the two-photon process is 2.5 mM, which is suitable for dynamic Mg2+ concentration measurement. In addition, the probe is capable of imaging endogenous stores of free Mg2+ at a few hundred micrometers depth in live tissues using two-photon microscopy (TPM)."

Osteoblasts were grown in tissue culture, and were exposed once daily to NIR light
with a total energy of 4J/cm and wavelengths of 670 nm, 830 nm or 880 nm.

*Osteoblast* proliferation was increased by all
wavelengths, with the greatest increases being seen following irradiation at 830 and 880nm.

Our data demonstrate that NIR light enhances cellular
proliferation, with the greatest effects being seen at 830nm.

Interestingly, while proliferation was enhanced by NIR
light, secretion of several important markers of osteoblast function such as osteocalcin, ALP, and TGF-β were
significantly delayed, suggesting that the primary effects of the NIR irradiation were to promote cellular
proliferation over differentiation.

Taken together, these results suggest that NIR light may play an important role in
the enhancement of fracture healing.

www.utmb.edu/nsrf/2007%20NSRF%20Program.pdf

Isn't that the goal of Tetracycline too...decrease extracellular Ca....and why vitamin D levels go up too?

Corticosteroids * inhibit* the delivery of short-term activational pulses of phorbol ester and calcium ionophore to human peripheral T cells. Cell. Immunol. 140:145-157.
25. Meier, C., F. Grahmann, A. Engelhardt, and M. Dumas. 1989. Peripheral nerve disorders in Lyme-borreliosis: nerve biopsy studies from eight cases.
Acta Neuropathol. 79:271-278.

Look closely at what activates and what inhibits PFK1.

Bb's OspA protein locks onto epinephrine and norepinephrine at the outset.

And you know, of course, that steroids increase glucose...dramatically.

Common Function: NA+/CA+ exchange protein, putative
ID Organism Function
tr|O51186 Borrelia burgdorferi NA+/CA+ exchange protein, putative

1. Resting cells maintain the concentration of free Ca2+ ions in the cytosol between 10-8 and 10-7 M.
2. The sole function of calcium in the cytosol is to transmit information.
3. The target of calcium, functioning as a second messenger, is a protein(s) in the cytosol.
4. Calcium modulated proteins are homologs, containing EF-hands.

5. Cells ***extrude calcium so they can use phosphate as their energy currency***; Ca3(PO4)2 is insoluble.

"In brain cortex, it is well documented that the absence of calcium
stimulates glycolysis while an increase in calcium levels inhibits a variety of glycolytic enzymes."

http://www.ajbrui.com/files/AJBR_10099109.pdf.

African Journal of Biomedical Research, Vol. 10 (2007)

Normalised k values of the reaction with 635 and 830 nm laser irradiation at 6 J/cm2. Both lasers at this dose increased the k of this ATP-dependent ...
linkinghub.elsevier.com/retrieve/pii/S1010603004002680

Beneficial effects of laser therapy in acute small joint inflammation in rheumatoid arthritis has been described by Asada et al (6). Multiple point irradiation using a GaAlAs diode (830 nm:60 mW) was applied for 15 seconds to each point. Pain was reduced by up to 66 % together with an improvement in the measured range of movement (ROM).

http://www.laserpartner.cz/lasp/web/en/2004/0072.htm

We have reanalyzed the dose-response curve of that study by using WEBMAXC and have arrived at an apparent EC50 for

TRPM4 activation of 880 nM.

The cytosolic calcium concentration was monitored at a rate of 5 Hz with a photo-multiplier-based system.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=299937

Transient receptor potential (TRP) channel, melastatin subfamily (TRPM)4 is a Ca2+-activated monovalent cation channel that depolarizes the plasma membrane and thereby modulates Ca2+ influx through Ca2+-permeable pathways. A typical feature of TRPM4 is its rapid desensitization to intracellular Ca2+ ([Ca2+]i).
http://www.nature.com/emboj/journal/v25/n3/abs/7600963a.html

Myogenic vasoconstriction results from pressure-induced vascular smooth muscle cell depolarization and Ca2+ influx via voltage-dependent Ca2+ channels, a process that is significantly attenuated by inhibition of protein kinase C (PKC).

http://stke.sciencemag.org/cgi/content/abstract/ajpheart;292/6/H2613


These are known as 2-arachidonyl glycerol (2-AG) and anandamide.

The researchers demonstrated that of the two substrates, 2-AG is the best one for COX-2, and they have identified four final products of this selective COX-2 pathway, known as glyceryl prostaglandins.

About glyceryl:

Glycerol-3-Phosphate Acquisition in Spirochetes: Distribution and Biological Activity of Glycerophosphodiester Phosphodiesterase (GlpQ) among Borrelia Species...

In Japan, there's even an "Infrared society" composed of medical doctors dedicated to further FIR research. Their findings support the outstanding health benefits of FIR.

Far Infra-Red Rays:
Improve circulation by exerting strong rotational and vibration effects at the molecular level.

Enhances the delivery of oxygen and nutrients in the blood cell to the body's soft tissue areas.

Promotes regeneration of cells and tissues.

Increases metabolism between blood and tissue.

Enhances white blood cell function, thereby eliminating of foreign pathogens and cellular waste.

http://www.peloop.com/

CONCLUSIONS: These results demonstrate that FIR therapy exerts a potent anti-inflammatory effect via the *induction of HO-1* The ability of FIR therapy to
inhibit inflammation
may play a critical role in preserving blood flow and patency of AVFs in hemodialysis patients.
heme oxygenase-1 (HO-1), arteriovenous fistulas (AVFs)
PMID: 18202320 Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):739-45.

Heme oxygenase-1 (HO-1), a rate-limiting enzyme in heme catabolism (breakdown), has antioxidative, antiapoptotic, and antiinflammatory activities.

These data suggest that increasing HO-1 activity depletes heme, and this is associated with an attenuation of pulmonary artery relaxation and sGC activation responses to NO.
soluble guanylate cyclase (sGC)

http://ajpheart.physiology.org/cgi/content/abstract/294/3/H1244

Heme oxygenase 1 (HO-1) inhibits apoptosis (cell death) by regulating cellular prooxidant iron. We now show that there is an additional mechanism by which HO-1 inhibits apoptosis, namely by generating the gaseous molecule carbon monoxide (CO).

Overexpression of HO-1, or induction of HO-1 expression by heme, protects endothelial cells (ECs) from apoptosis.

http://www.jem.org/cgi/content/abstract/192/7/1015

These data suggest that HO-1 slows the progression to overt diabetes in prediabetic NOD mice by down-regulating the phenotypic maturity of dendritic cells and
Th1 effector function.

http://diabetes.diabetesjournals.org/cgi/content/abstract/db06-0495v1

Heme oxygenase-1 inhibits breast cancer invasion via suppressing the expression of matrix metalloproteinase-9

Molecular Cancer Therapeutics 7, 1195-1206, May 1, 2008

Conclusion
These results support the concept that HO-1 expression influences regulatory T cells and indicates that this mechanism is involved in the suppression of smoke induced B-cell infiltrates. The translation of this interaction to human COPD should now be pursued.
Chronic obstructive pulmonary disease (COPD)

http://respiratory-research.com/content/9/1/17 Respiratory Research 2008, 9:17

NASA...
We conclude that phytochrome B is required for the perception of gravity and that only red light is able to disrupt this perception.

http://www.photizo.co.za/pdf/article_nasa.pdf.

Carbon dioxide concentration can be accurately determined by using infrared analyzers, which operate on the principle that carbon dioxide absorbs specific infrared wavelengths...

http://www.nas.nasa.gov/About/Education/SpaceSettlement/Contest/Results/2002/Aether/Life%20Support.htm

Photobiomodulation Directly Benefits Primary Neurons Functionally Inactivated by Toxins
J. Biol. Chem., Vol. 280, Issue 6, 4761-4771, February 11, 2005

Far red and near infrared (NIR) light promotes wound healing, but the mechanism is poorly understood. Our previous studies using 670 nm light-emitting diode (LED) arrays suggest that cytochrome c oxidase, a photoacceptor in the NIR range, plays an important role in therapeutic photobiomodulation.

If this is true, then an irreversible inhibitor of cytochrome c oxidase, potassium cyanide (KCN), should compete with LED and reduce its beneficial effects.

This hypothesis was tested on primary cultured neurons. LED treatment partially restored enzyme activity blocked by 10-100 M KCN.

It significantly reduced neuronal cell death induced by 300 M KCN from 83.6 to 43.5%. However, at 1-100 mM KCN, the protective effects of LED decreased, and neuronal deaths increased.


LED significantly restored neuronal ATP content only at 10 M KCN but not at higher concentrations of KCN tested.

Pretreatment with LED enhanced efficacy of LED during exposure to 10 or 100 M KCN but did not restore enzyme activity to control levels. In contrast, LED was able to completely reverse the detrimental effect of tetrodotoxin, which only indirectly down-regulated enzyme levels.

Among the wavelengths tested (670, 728, 770, 830, and 880 nm), the most effective ones (830 nm, 670 nm) paralleled the NIR absorption spectrum of oxidized cytochrome c oxidase, whereas the least effective wavelength, 728 nm, did not.

The results are consistent with our hypothesis that the mechanism of photobiomodulation involves the up-regulation of cytochrome c oxidase, leading to increased energy metabolism in neurons functionally inactivated by toxins.


Near infrared (NIR)1 light has been used in therapeutic devices for the treatment of a variety of injuries, especially infected, ischemic, and hypoxic wounds (1-4). NIR light penetrates more deeply than UV or visible light and is benign to living tissue.


This presents clear clinical advantages to treatment within a tissue transparency window of 650-1000 nm. Most of the devices utilize lasers as the light source. Recently, however, light-emitting diodes (LEDs) have been found to be more beneficial than lasers in several respects (3, 5).

LEDs can be constructed to form relatively large arrays to treat wounds that commonly involve areas much larger than the size of a laser beam. Unlike lasers, there is virtually no heat generated by the LED array and therefore no potential thermal injury to individuals being treated.

LED is well tolerated by biological tissues and has no known detrimental effect. As a therapeutic device, LED has achieved FDA non-significant risk status. Moreover, LED units are more compact, portable, and affordable than lasers.

The cellular mechanisms of action of NIR in wound healing are not well understood. The basic premise is that long wavelength lights stimulate cellular energy metabolism and energy production.

Three major photoacceptor molecules in mammalian tissues are known to absorb light in the NIR range: hemoglobin, myoglobin, and cytochrome c oxidase.

Of the three, only cytochrome c oxidase (EC 1.9.3.1 [EC] ) has been associated with energy production. In our recent study, the first two candidates were excluded in our primary neuronal cultures in which more than 95% of the cells were neurons, and there were no blood elements or muscle cells (6).

In the presence of a voltage-dependent sodium channel blocker, tetrodotoxin (TTX), which impedes neuronal impulse activity, decreases ATP demand, and down-regulates cytochrome c oxidase activity, LED at 670 nm was able to reverse the detrimental effect of TTX by bringing cytochrome c oxidase back to control levels.

Moreover, LED treatment up-regulated enzyme activity of normal neurons above control levels (6).
The beneficial effect of NIR was further confirmed in our recent in vivo study.

Rats intoxicated with methanol developed retinal dysfunction attributable to the inhibition of cytochrome c oxidase by formic acid, the toxic metabolite in methanol intoxication.

Three brief LED treatments significantly improved retinal function as measured by the electroretinographic response and protected the retina from histopathological changes induced by methanol-derived formate (7).

Thus, photobiomodulation is therapeutic in restoring visual functions after reversible inhibition of cytochrome c oxidase by formate.
Our in vitro and in vivo studies thus far suggest that cytochrome c oxidase plays an important role in the therapeutic process of photobiomodulation.

A comparison of the action spectrum for cellular proliferation following laser photoirradiation with the absorption spectra of potential photoacceptors led Karu (8) to suggest that cytochrome c oxidase is a primary photoacceptor of light in the far red to near infrared region.

Britton Chance's group postulated that 50% of near infrared light is absorbed by mitochondrial chromophores such as cytochrome c oxidase (9). To further investigate this question, the present study tested the following hypotheses: 1) cytochrome c oxidase is directly involved in the photobiomodulation reaction; therefore, a potent and irreversible inhibitor of cytochrome c oxidase such as potassium cyanide (KCN) will compete with and lessen the beneficial effect of LED.

2) LED treatment stimulates cytochrome c oxidase activity in neurons; therefore, LED pretreatment will further enhance the partial protective action of LED during exposure to KCN. 3) By increasing cytochrome c oxidase activity and cellular energetics, LED will reduce neuronal cell death caused by the cytotoxin KCN.

Finally, 4) the effective action spectrum of LED in reversing the detrimental effect of the impulse blocker tetrodotoxin on cytochrome c oxidase activity should correspond to the NIR absorption spectrum of cytochrome c oxidase. Various wavelengths of LED were tested to see if specific ones were more beneficial to functionally inactivated neurons.

Wavelengths were administered either singly or in combination to determine the optimal conditions for treatment. Primary neuronal cultures were again our model system because (a) primary neurons are more physiological than cell lines, (b) neurons are highly oxidative, and (c) experimental conditions can be manipulated to affect neurons without complications from other cell types.

Cytochrome c oxidase is the terminal enzyme in the electron transfer chain.
(Physiologically, it reduces oxygen to water and utilizes the excess energy to translocate protons across the mitochondrial membrane.

The enzyme is responsible for over 90% of the oxygen consumption by living organisms in the biosphere; yet the mechanism of its basic function, the coupling between the redox processes and proton translocation is undetermined.)"

Free Radic Biol Med. 2007 Jul 1;43 (1):128-135 17561101
Cellular response to infrared radiation involves retrograde mitochondrial signaling.
Peter Schroeder , Corinna Pohl , Christian Calles , Corinna Marks , Susanne Wild , Jean Krutmann
Infrared A radiation (IRA) is a major component of sunlight. Similar to ultraviolet (UV) B and UVA, IRA induces gene transcription. In contrast to the UV response very little is known about the IRA response. In the present study, IRA-induced expression of matrix metalloproteinase-1 (MMP-1) was found to be mediated by the formation of intracellular reactive oxygen species (ROS). Staining of IRA-irradiated cells with MitoSox revealed an increase in mitochondrial superoxide anion production and treatment of fibroblasts with the mitochondrial targeted antioxidant MitoQ completely abrogated the IRA, but not the UVB or UVA1, response. ROS relevant for IRA-induced signaling originated from the mt electron transport chain, because (i) chemical inhibition of the electron transport chain prevented IRA, but not UVB or UVA1, radiation-induced MMP-1 expression, (ii) rho0 fibroblasts specifically failed to increase MMP-1 expression in response to IRA, and (iii) peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) overexpressing fibroblasts with increased electron transport chain content were hypersensitive to IRA radiation-induced gene expression. Thus, IRA, in contrast to UV, elicits a retrograde signaling response in human skin.

The inactivation of the enzymes lipase and α-amylase were studied during treatment by far-infrared (FIR) radiative heating and compared with activity changes due to heating by thermal conduction. The decrease in enzyme activity was found to be largely similar for the two processes, as long as the temperature profiles of the enzyme solutions were identical during heating. The inactivation of α-amylase was compared with bacterial death (Escherichia coli) using both FIR and conductive heating. The inactivation energy required to inactivate enzymes was an order of magnitude lower than that for inactivation of E. coli and the death rate constants of bacteria (kdeath) became larger than the inactivation rate constant of the enzyme (ken) at about 50 C or higher. At the given temperatures, the kdeath values for FIR was larger than kdeath values for conductive heating, suggesting that FIR heating may allow a given pasteurization target level to be achieved at lower temperatures than by conductive heating, while maintaining enzyme activity levels.
http://www.blackwell-synergy.com/doi/abs/10.1046/j.1365-2621.2003.00717.x?journalCode=ifs

J Clin Laser Med Surg, 2003 Aug, 21 - 4, 231 - 5
A preliminary investigation into light-modulated replication of nanobacteria and heart disease; Sommer AP et al.; OBJECTIVE: The purpose of this preliminary study is to evaluate the effect of various wavelengths of light on nanobacteria =NB . BACKGROUND

DATA: NB and mitochondria use light for biological processes .

NB have been described as multifunctional primordial nanovesicles with the potential to utilize solar energy for replication .

NB produce slime, a process common to living bacteria .

Slime release is an evolutionary important stress-dependent phenomenon increasing the survival chance of individual bacteria in a colony . In the cardiovascular system, stress-induced bacterial colony formation may lead to a deposition of plaque . METHODS: Cultured NB were irradiated with NASA-LEDs at different wavelengths of light: 670, 728 and 880 nm . Light intensities were about 500k Wm(-2), and energy density was 1 x 10(4) J m(-2) . RESULTS: Monochromatic light clearly affected replication of NB . Maximum replication was achieved at 670 nm .

CONCLUSIONS: The results indicate that suitable wavelengths of light could be instrumental in elevating the vitality level of NB,

preventing the production of NB-mediated slime,

and simultaneously increasing the vitality level of mitochondria .

The finding could stimulate the design of cooperative therapy concepts that could reduce death caused by myocardial infarcts.''


OBJECTIVE: This paper describes the successful treatment of two patients with chronic fatigue syndrome (CFS) using repeated thermal therapy. METHODS: Two patients with CFS underwent treatment with prednisolone (PSL), with no satisfactory effect. They were subjected to thermal therapy that consisted of a far-infrared ray dry sauna at 60 degrees C and postsauna warming. The therapy was performed once a day, for a total of 35 sessions. After discharge, these subjects continued the therapy once or twice a week on an outpatient basis for 1 year. RESULTS: Symptoms such as fatigue, pain, sleep disturbance, and low-grade fever were dramatically improved after 15 to 25 sessions of thermal therapy. Although PSL administration was discontinued, the subjects showed no relapse or exacerbation of symptoms during the first year after discharge. The patients became socially rehabilitated 6 months after discharge. CONCLUSIONS: These results suggest that repeated thermal therapy might be a promising method for the treatment of CFS.
Ann Neurol. 2005 Feb ;57:289-93 15668981

Far infrared penetrates bones:

http://tinyurl.com/6dt7kv

http://cat.inist.fr/?aModele=afficheN&cpsidt=17162656

http://www.ninds.nih.gov/news_and_events/proceedings/nirs_workshop.htm (second paragraph)

And...

http://www.medicalnewstoday.com/articles/95334.php

http://tinyurl.com/6co5cf

Edited to fix looong URL. Lou B

[ 23. July 2008, 10:03 PM: Message edited by: Lou B ]

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Niek
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Hi Marnie,

I'm afraid you are mixing up some different things.

radio therapy (and far infrared that some of these papers talk about) has nothing to do with 'biophotons' or near infrared light (700-1500 nm or so) as used in the devices we are talking about here. Some of the references is about studies using detectors that detect IR light, instead of devices that emit IR. Part of the research mentioned could be interesting, but I don't see compelling evidence regarding the benefit of the specific 880nm wavelength ... Just a few comments:

quote:

As a scientist, I'm sure you know also that the 880nM wavelength (energy) is absorbed by phosphate.

I didn't know that, but why not? Thousands of biological substances have absorption bands in the infrared region (or in visual / UV etc.).

quote:
Taken together, these results suggest that NIR light may play an important role in
the enhancement of fracture healing'

probably, one of the many effects of IR light. Because of this, devices using IR light can be beneficial if someone is ill (or sometimes harmfull as well, probably ...).

quote:
DATA: NB and mitochondria use light for biological processes.
If it would really work like that for humans, people could live on just a tiny bit of food and infrared light only. And people would die if kept in the dark for too long [Wink]
I don't doubt our mitochondria are influenced by light, they just don't use it for ATP synthesis (at least not on any significant scale). And even if they did, it is very difficult to get to the specific target - we don't want to boost the parasites, do we [Roll Eyes]

quote:
NASA...
We conclude that phytochrome B is required for the perception of gravity and that only red light is able to disrupt this perception.

phytochrome B is a photoreceptor that occurs only in plants and certain bacteria; although somewhat similar pigments exist in humans we simply don't have this one.

Of course near-infrared light (e.g. when absorbed by the skin) has influence on lots of biochemical processes, sometimes simply as a result of the temperature increase, and maybe sometimes because of absorption of specific wavelengths by photosensitive pigments (although near-IR does get only a mm or so into the skin). Some biochemical reactions can increase 10-fold in speed from just a few degrees of temperature increase.

Many people get some benefit from just an infrared lamp over a sore spot, or infrared sauna, etc. Maybe some specific wavelengths work better, but there is very little official science to support that as of yet (but again, who knows - maybe future research will present more support for that).

[ 21. July 2008, 08:38 AM: Message edited by: Niek ]

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lymie_in_md
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Niek why is the 1072nm 700 LED helmet used for dimentia so successful if light isn't a factor?

--------------------
Bob

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pamoisondelune
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My husband says that a 200 watt tungsten lamp peaks at about 880 the same as an LED, so why not just use a heat lamp?
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sparkle7
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I've used an infrared sauna, a regular heating pad, & a red & infrared LED device.

I can definitely say that the LED device has produced the most dramatic results in pain relief for me. It's not just the heat. If that were the case the heating pad would have worked just as well as the LED device.

I do think humans need light. Like I always say, I'm no scientist but I think there are important components in light that humans need.

Some people have adapted to their habitat by having darker or lighter skin in regards to the climate & latitude but I believe light is important to health.

After all the studies that Marnie & I have posted, I don't see how you can still think there are no benefits to using light as a healing modality.

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Marnie
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Bob...go here and find every link to the

AB42/AB40 ratio:

http://archiv.ub.uni-heidelberg.de/volltextserver/volltexte/2008/8496/pdf/Dissertation_Markus_Uhrig.pdf

I think only you and I will understand.

Niek...

"Infrared is usually divided into 3 spectral regions: near, mid and far-infrared. The boundaries between the near, mid and far-infrared regions

are not agreed upon and can vary.

The main factor that determines which wavelengths are included in each of these three infrared regions is the type of detector technology used for gathering infrared light."

http://coolcosmos.ipac.caltech.edu/cosmic_classroom/ir_tutorial/irregions.html

"Electroluminescence is an optical
phenomenon and electrical phenomenon.

The electric field excites electrons in the material which then emit the excess energy as in the material as

photons.

LEDs are the most well known example of electroluminescence."

So...LEDs emit excess energy.

"Today it is well accepted that photons of different wavelengths trigger certain biological functions, as, for instance, photorepair, phototaxis, photoperiodic clocks, cell divisions, and multiphoton events.

For a long time, however, it was on the contrary less accepted that all living tissues themselves emit a quasi-continuous photo radiation.

This phenomenon of "ultraweak" photon emission from living cells and organisms which is different from bioluminescence, exhibits an intensity of a few up to some hundred photons per second and per square centimeter of surface area.

Its spectral distribution ranges at least from infrared (at about 900 nm) to ultraviolet (up to about 200 nm). Recently, the most modern aspects of "biological luminescence" were extensively discussed."

"Biophotons, or ultra weak photon emissions of biological systems, are weak electromagnetic waves in the optical range of the spectrum - in other words: light.

All living cells of plants, animals and human beings emit biophotons which cannot be seen by the naked eye but can be measured by special equipment developed by German researchers.

This light emission is an expression of the functional state of the living organism and its measurement therefore can be used to assess this state."

Returning for a second to "general":

WHAT IS LIGHT?
Waves: Light is electromagnetic waves. The wavelength is measured in
nanometers (abbreviated nm).

Particles: Light is photons, which are a quantum, or individual unit.

Since individual photons possess tiny amounts of energy, photons are measured
in units of moles (abbreviated mol),
which are each 6.02 x 1023 photons.

Micromoles (abbreviated μmol) are one-millionth of a mole."

Now for the good stuff:

"QUALITY

***Photons have different amounts
of energy, determined by their
wavelengths.***

Light quality is the
relative number of light particles at
each wavelength.

Light quality refers
to the spectral distribution of light, or
the relative number of photons of each
portion of the light spectrum (visible and
invisible) emitted from a light source."

Niek, you were right about phytochrome B only being in plants.

Curious, isn't it that it is involved in the circadian rhythm of plants?

However,

This is even more strange:

We have found that the two blue-light photoreceptors, cryptochromes 1 and 2 (CRY1 and CRY2), recently discovered in mammals are specifically expressed in the ganglion cell and inner nuclear layers of the mouse retina.

In addition, CRY1 is expressed at high level in the SCN and oscillates in this tissue in a circadian manner.

These data, ***in conjunction with the established role of CRY2 in photoperiodism in plants***,

lead us to propose that mammals have a vitamin A-based photopigment (opsin) for vision and a vitamin B2-based pigment (cryptochrome) for entrainment of the circadian clock.

http://www.pnas.org/content/95/11/6097.abstract

Geeze...there is 1 and 2 again...1 downregulated and 2 up.

COX-2 "on", PGE-2 "on", HO-2 "on"

When we need protective COX-1 activated -> PGE-1 -> HO-1 -> Fe (which can destroy Bb), CO (which Bb can handle...gene to do so) and biliverdin (green)...reacts with red -> yellow wavelength = Na channels close. Bb is kapoot.

Okay..so we're dealing with melatonin (cutting to the chase)

Chemical Formula: C13H16N2O2.

H16...the "vascular damage group".

I understand this:

http://cat.inist.fr/?aModele=afficheN&cpsidt=17471891

I also know if serine is not phosphorylated, the HPA axis (HYPOTHALAMUS, pituitary and ADRENAL gland signals are off)

"Delta-Sleep-Inducing Peptide Stimulates Melatonin, 5-Methoxytryptophol and Serotonin Secretion from Perifused Rat Pineal Glands"

Like I've been saying...Bb's PKCD inhibitor is a huge problem.

Want to discuss the 14-3-3 proteins?

Bob...dictionary and here:
http://www.biochemj.org/bj/381/0329/bj3810329.htm

It is good to see the helmets do look like they are helping...significantly.

We need phosphate transfer and we need the energy to make it happen...the photons in the far infrared wavelength.

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Niek
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quote:
Originally posted by lymie_in_md:
Niek why is the 1072nm 700 LED helmet used for dimentia so successful if light isn't a factor?

did I say light isn't a factor? I'm just trying to debunk all the non-science quotes here and show what solid science is behind it (very little, up to now).

From what I have read this helmet is very controversial; like many other devices there are no objective (from other institutions/researchers), double-blind placebo trials demonstrating that it works. And again: now we are talking about 1072 nm - what is the right wavelength then??

quote:
Originally posted by pamoisondelune:
My husband says that a 200 watt tungsten lamp peaks at about 880 the same as an LED, so why not just use a heat lamp?

I think the main issue is that tungsten lamps have more infrared radiation at higher wavelength, increasing the 'heat' problem. Another difference is that LED lamps don't have a continuous spectrum (contrary to sunlight, tungsten lamps etc.) but peaks/bands at certain wavelengths. It could make a difference, but then you have to show that specific wavelengths (e.g. those where the LED lamps peak) are important for activating certain systems in the body.

quote:
Originally posted by sparkle7:
I do think humans need light. Like I always say, I'm no scientist but I think there are important components in light that humans need.

Of course we do, but there is a huge difference between responding to light for circadian rhythm or other specific functions and using light for energy production (only plants and some bacteria can do that).

quote:
Originally posted by Marnie:
"Infrared is usually divided into 3 spectral regions: near, mid and far-infrared. The boundaries between the near, mid and far-infrared regions ... are not agreed upon and can vary.

sure, but there is no discussion about 880nm being near infrared.

"Today it is well accepted that photons of different wavelengths trigger certain biological functions, as, for instance, photorepair, phototaxis, photoperiodic clocks, cell divisions, and multiphoton events.

fully agree ... a lot of things happen biochemically if you simply step into the sun; nothing new there ...

"All living cells of plants, animals and human beings emit biophotons which cannot be seen by the naked eye but can be measured by special equipment developed by German researchers.

This light emission is an expression of the functional state of the living organism and its measurement therefore can be used to assess this state."

yes, but it is an ultraweak EMISSION; that has basically nothing to do with body components that capture external light/near IR radiation. Also, there is still lots of doubt if this ultraweak emission is a 'real' phenomenon or just a side effect. EVERYTHING emits photons under the right conditions, including dead matter. There is nothing special about these German detectors, they are just VERY sensitive because these photon emissions are close to zero.

Everything emitted by a human body can tell something about its condition (including speach, sound, smell etc.); nothing new about that, the problem is that we don't know exactly how to decode these signals. Some of these have a very bad signal/noise ratio. And again: those are (at best) emissions coming from the body, it is not IR/light going in the reverse direction!

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Thanks Niek for replying to the 1072nm frequency.

This is just such new territory. If we do not use light to generate energy, then maybe we just need the photons for intercellular communication. So my initial understanding for why the 880nm is for that communication. Some cells are no longer communicating with each other causing dysregulation. Could the 880nm be used in this manner?

Like h-pylori when Dr. Marshall infected himself to prove to the scientific community bacteria can live in the stomach. We aren't much different. Like all ventures risks are taken, people have gone to germany and they are posting there status. We can determine the next steps as a group.

--------------------
Bob

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Niek
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quote:
Originally posted by lymie_in_md:
If we do not use light to generate energy, then maybe we just need the photons for intercellular communication.

sure! that is the hypothesis of biophoton theory (most of that intercellular communication is still unproven however). And I doubt if it applies to the photons that are coming out of the body (skin), they may be mostly 'noise'. Also, I severely doubt if you can 'communicate' with the body by putting some LED lamp or IR laser at certain points.

quote:
So my initial understanding for why the 880nm is for that communication. Some cells are no longer communicating with each other causing dysregulation. Could the 880nm be used in this manner?
good question, but unlikely IMHO. It sounds like trying to fix a blocked internet link by sending a load of SPAM, or influence a heated discussion where no one is communicating any longer with a loud bang (well, that MIGHT work) [Wink]

Following up on other things that were mentioned about the subject: if 880nm (or some other near-IR wavelength, I don't think it needs to be 880) stimulates wound healing, it might repair some other damaged cell processes as well. Again, we know very little about the actual healing process in our bodies (stem cells, morphogenetic fields etc.) so there could be some surprises.

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"Of course we do, but there is a huge difference between responding to light for circadian rhythm or other specific functions and

using light for energy production (only plants and some bacteria can do that)."


? We don't use light for energy production/transmission?

"But thanks to recent breakthroughs in brain science, companies can now actually see what goes on inside our minds when we shop.

Teams of academic and corporate neuromarketers have begun to hook people up to functional magnetic resonance imaging (fMRI) machines in order to map how their neurons respond to products and pitches.

Last year, the journal Neuron published an article called ``Neural Predictors of Purchases'' by a group of scholars from three leading U.S. universities.

The researchers described how they had used brain imaging to monitor the mental activity of shoppers as they evaluated products and prices on computer screens.

***By watching how different neural circuits light up or go dark during the buying process***, the researchers found they could predict whether a person would end up purchasing a product or passing it up.

They concluded, after further analysis of the results, that ``the ability of brain activation to predict purchasing would generalize to other purchasing scenarios.'' Forbes heralded the study as a milestone in business, saying it marked the first time researchers have been able ``to examine what the brain does while making a purchasing decision.''

We indeed "light up"... transfer signals...or go dark.

More...

``We can start to sort of speak the language of the brain using

optical excitation,''

Dr. Deisseroth said. The brain's functions ``arise from the orchestrated participation of all the different cell types, like in a symphony,'' he said.

Laser stimulation can serve as a musical conductor, manipulating the various kinds of neurons in the brain to reveal which important roles they play.

This light-switch technology promises to accelerate scientists' efforts in mapping which clusters of the brain's 100 billion neurons warble to each other when a person, for example, recalls a memory or learns a skill. That quest is one of the greatest challenges facing neuroscience.

The channelrhodopsin switch is ``really going to blow the lid off the whole analysis of brain function,'' said George Augustine, a neurobiologist at Duke University in Durham, N.C.

Dr. Deisseroth, who is also a psychiatrist who treats patients with autism or severe depression, has ambitious goals. Brain cells in those disorders show no damage,

***yet something is wrong with how they talk to one another, he said.***

``The ***high-speed dynamics***of the system are probably off,'' Dr. Deisseroth said. He wants to learn whether, in these neuropsychiatric diseases, certain neurons falter or go haywire, and then to find a way to tune patients' faulty circuits....

Neuroscientists have long sought a better alternative than electrode stimulation.

In the past few years, some have jury-rigged ways to excite brain cells by using light;

one technique used at Yale made headless fruit flies flap away.

But these methods had limitations. They worked slowly, they could not target specific neurons or they required adding a chemical agent.

More recently, Dr. Isacoff, with Dirk Trauner, a chemistry professor at the University of California, Berkeley, and other colleagues engineered a high-speed neural switch by refurbishing a channel protein that anchors in the cell membrane of most human brain cells.

The scientists tethered to the protein

a light-sensitive synthetic molecular string that has glutamate,

a neurotransmitter, dangling off the end.

Upon absorbing violet light, the string plugs the glutamate into the protein's receptor and sparks a neuron's natural activation process: the channel opens, positive ions flood inside, and the cell unleashes an electrical impulse.

In experiments published in May in the journal Neuron, the Berkeley team bred zebrafish that carried the artificial glutamate switch within neurons that help sense touch.

``If I were a fish, and somebody poked me in the side,'' (in this case, with a fine glass tip), Dr. Isacoff said, ``I would escape.'' But when the translucent fish were strobed with violet light, the overstimulated creatures no longer detected being prodded. Blue-green light reversed the effect.

One advantage of the Berkeley approach, Dr. Isacoff said, is that it can be adapted for many types of proteins so they could be activated by light.

But for the method to work, scientists must periodically douse cells with the glutamate string."

No problem...glutamate levels are very high in lyme.

Curious:

"Neuroscientists realized that this pond scum protein might be used to hot-wire a neuron with light. In 2005, Edward Boyden, then a graduate student at Stanford, Mr. Zhang and Dr. Deisseroth, joining with the German researchers, demonstrated that the idea worked.

And in separate research published last spring, Mr. Zhang and Dr. Boyden, now at the Massachusetts Institute of Technology, each found a way to also silence neurons:

a bacterial protein called halorhodopsin, when placed in a brain cell, can cause the cell to shut down in response to yellow light.

The Stanford-Germany team put both the ``on'' and ``off'' toggles into the motor neurons or muscle cells of transgenic roundworms. Blue light made the creatures contract their muscles and pull back; yellow let them relax their muscles and inch forward."

Blue - Ca influx? We know "shocking" the heart = Ca influx to start it beating once again.
Yellow - Mg influx?

"Such research benefits could extend beyond the realm of neuroscience: The Stanford group has sent DNA copies of the ``on'' and ``off'' light-switch genes to more than 175 researchers eager to try them in all stripes of electrically excitable cells, from insulin-releasing pancreas cells to heart cells."

"Reactive oxygen species (ROS) readily oxidize the sulfur-containing amino acids cysteine and methionine (Met).

The impact of Met oxidation on the fast inactivation of the skeletal muscle sodium channel Na(V)1.4 expressed in mammalian cells was studied by applying the Met-preferring oxidant chloramine-T or by irradiating the ROS-producing dye Lucifer Yellow in the patch pipettes.

Both interventions dramatically slowed down ***inactivation*** of the sodium channels."

Once again...in the 1940s, Dr. Royal Rife made a microscope using many prisms to magnify. Since these prisms bend light, he was able to see how different pathogens responded to different "colors" (wavelengths).

Niek, I do realize your HO-1 concerns as this is expressed in many cancer cells (as a possible protective attempt?)!

Keep this in mind (Bb has "zinc fingers"):

Zn(II)PPIX induced significant accumulation of reactive oxygen species in tumor cells.

***This effect was partly reversed by administration of exogenous bilirubin.***

And HO-1 -> PGE-1 -> HO-1 -> Fe (toxic to Bb), CO (Bb can deal with it), and biliverdin which converts to bilirubin...which can be lowered by UVB.


Prostate cancer cells lack PKCD. No surprise here...Bb looks to have a PKCD inhibitor.

If Bb is causing the upregulation of CYP2 and

downregulation of CYP1...

Cytochrome p-450 1 Family CYP1. (P-450...detoxification).

pro-apoptotic functions ... Autophagic cell death ... Cyp1, X, X

2 "Xs"...women...less detoxification ability.

Bb is using ALA in an outer surface protein and ROS "oxidize" it and this triggers MORE ROS.

"High ALA is thought to cause some of the neurological effects of lead poisoning, although Pb++ also may directly affect the nervous system.

ALA (delta
-aminolevulinate)

is toxic to the brain. This may be due in part to the fact that ALA is somewhat similar in structure to the neurotransmitter GABA (g-aminobutyric acid). In addition, autoxidation of ALA generates reactive oxygen species (oxygen radicals).

Aminolevulinate dehydratase down and ALA synthesis up...in fatigue.

delta-Aminolevulinate dehydratase deficient porphyria, a recently recognized inborn error of

heme biosynthesis,

results from the markedly deficient activity of the heme biosynthetic enzyme, delta-aminolevulinate dehydratase (ALA-D).

Coupled with low levels of PKC -> RBC destruction.

Whoa:

http://www.emedicine.com/ped/byname/Porphyria--Acute.htm

Now some more...and questions:

CYP enzymes are a superfamily of hemoproteins...

Taken together, these results indicate that tryptophan is a precursor of the endogenous ligand and that the suggested tryptophan-derived ligand FICZ is a substrate for the CYP1A1 enzyme and is involved in autoregulation of CYP1A1 transcription.

Arch. Biochem. Biophys. (2000)
PMID: 11097181

Bb can NOT grow in gelatin which contains all the amino acids (from what I've read) except tryptophan. One would logically think: Bb needs tryptophan to survive (and gene analysis says so).

Is Bb triggering CYP1 and CYP2? Those enzymes are hemoproteins. Are we then unable to use available heme to make oxygen carrying hemoglobin?

Is Bb using transferrin-Mn? Can we fool Bb by substituting gallium (ideally as maltoate - safer! but other forms are available)?

Don't we have to somehow trigger phosphate transfer...increase ATP in the infected cells...to drive Mg back into the cell where it can (in high enough amts.) displace Zn and Mn.

How vital is phosphatidyl serine? Reservatrol and curcumin?

Curcumin from tumeric is YELLOWish. Reservatrol is in RED wine. The combination to inhibit CYP2 and CYP1?

A functional linkage between potent induction of the major CYP (1-3) genes and transcriptional down-regulation of MDR1 gene in

drug-resistant tumor cells is hereby hypothesized."

Do we need to get BOTH CYP1 and CYP2 down?

How?

Is it the abundance of PDE1 in the Western Fence Lizard (which needs to see at night - rods)...that is the protective enzyme which is destroyed by heating.

PDE1 needs Ca present IN the cell to work. Hence Mg takes a "hike"...bigtime (Mg out, Ca in)...and fast for multiple reasons (including inactivating HMG Co-A reductase, helping to make defense enzymes and proteins, etc.

Now...how to activate PDE1?

Keep calcium IN the cells?

Well...we know far infrared helps the osteoblasts (bone BUILDERS)...

I have found a link, I think. 695nM (very close)

looks to ***excite carbon***.

(Diamond experiments and diamonds are hard pressed carbon)

ferricytochrome C (that's the first time I have seen cytochrome C with the prefix "ferri"...binds to CO.

Well...for all you researchers trying hard along with me to understand:

band from the visible
absorption spectrum of native ferricytochrome c corresponds to
the formation of five-co-ordinate haem due to the loss of Met-80
ligation (Sreenathan & Taylor, 1971), and that a correlation
exists between the property of ascorbate-reducibility and the
presence of this absorption band (Greenwood & Palmer, 1965).
The carbodi-imide-modified proteins lack the 695 nm band of
native ferricytochrome c, bind CO and 02, and yet retain
ascorbate-reducibility (Timkovich, 1980; Mathews & Brittain,
1987), suggesting that intermediate structural states exist for
ferricytochrome c in which the protein structure surrounding the
haem is sufficiently disrupted to lead to loss of the 695 nm band
while retaining sufficient native structure to allow ascorbatereducibility
(Mathews & Brittain, 1987; Angstrom et al., 1982)

http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1151152&blobtype=pdf

Oddly enough...695nM (?) might correlate to 432Hz (which will ring a bell with Rifers).

I'm trying hard to figure out the conversions.

Welcome to OnlineConversion.com
Frequency Wavelength Calculator

[ 23. July 2008, 03:14 AM: Message edited by: Marnie ]

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sparkle7
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Laser Irradiation of the Blood

Levon Gasparyan, MD, PhD, Jerevan, Armenia
Published jointly in Laser Partner and Laser World (www.laser.nu)



Abstract

Evaluation of the methods of intravenous a transcutaneous irradiation of blood, known especially from scientific papers of Russian and Soviet authors. The article points out positive effects of laser irradiation on strengthening of the entire immune system.



Intravenous Laser Blood Irradiation Therapy


Currently the methods of laser and non-laser (incoherent monochromic, narrow-band or broadband) light blood irradiation therapy - the methods of photo-hemotherapy - are widely applied in the treatment of different pathologies. Direct intravenous and extracorporeal (with red, UV and blue light) as well as transcutaneous (with red and infrared light) irradiation of blood are used.

Unlike the treatment mechanisms of local laser therapy, the medical effects of photo-hemotherapy methods are determined by predominance of systemic healing mechanisms above the local ones, increasing the functioning efficacy of vascular, respiratory, immune, other systems and organism as a whole.


The method of HeNe intravenous laser blood irradiation (LBI) was developed in experiment and introduced in clinic in 1981 by Soviet scientists E.N. Meshalkin and V.S. Sergievskiy. Originally the method was applied in the treatment of cardiovascular pathologies.

Some authors reported that the treatment possibilities of the method are very large and include the improvement of rheological characteristics of the blood and microcirculation, normalisation of parameters of hormonal, immune, reproductive and many other systems.

HeNe laser (632.8 nm) is generally used for carrying out the intravenous laser blood irradiation (IV LBI). Usual parameters of blood irradiation procedure are: output power at the end of the light-guide inserted into a vein from 1 up to 3mW, exposition 20 - 60 minutes.

Procedures are conducted on a daily base, from 3 up to 10 sessions on a course of therapy.

It was shown, that IV HeNe LBI stimulates the immune response of the organism, activates erythrogenesis and improves deformability of erythrocyte membranes, has anti-hypoxic activity on tissues and general antitoxic influence on the organism at different pathological processes.

IV LBI is used for its biostimulative, analgetic, antiallergic, immunocorrective, antitoxic, vasodilative, antiarrhythmic, antibacterial, antihypoxic, spasmolytic, anti-inflammatory and some other properties.

IV LBI activates nonspecific mechanisms of anti-infectious immunity. Intensifying of bactericidal activity of serum of the blood and system of the complement, reduction of the degree of C - reactive protein, level of average molecules and toxicity of plasma, increasing the content of IgA, IgM and IgG in the serum of the blood, as well as decreasing of the level of circulating immune complexes are proved.

There are studies on boosting effect of IV LBI on the cellular part of immunity (N. F. Gamaleya et al., 1991). Under influence of IV LBI the phagocytic activity of macrophages markedly increases, concentration of microbes in exudate in the abdominal cavity of patients with peritonitis decreases, reduction of inflammatory exhibiting of disease, activation of microcirculation are detected.

The medical effect of IV LBI is stipulated by its immuno-corrective activity by normalisation of intercellular relationships within the subpopulation of T-lymphocytes and increasing the amount of immune cells in a blood.

It elevates the function activity of B-lymphocytes, strengthens the immune response, reduces the degree of intoxication and as a result improves the general condition of patients (V. S. Sergievskiy et al., 1991).

IV LBI promotes improving the rheological properties of blood, rising fluidity and activating transport functions. That is accompanied by increasing the oxygen level, as well as decreasing the carbon dioxide partial pressure.

The arterio-venous difference by oxygen is enlarged, that testifies the liquidation of a tissue hypoxia and enrichment the oxygenation. It is a sign of normalisation of tissue metabolism. Probably, the basis of activation of oxygen transport function of IV LBI is the influence on hemoglobin with transforming it in more favorable conformation state.

The augmentation of oxygen level improves metabolism of the organism tissues. In addition, the laser irradiation activates the ATP synthesis and energy formation in cells (A. S. Krjuk et al., 1986). Application of IV LBI in cardiology has shown that procedures have analgetic effect, show reliable rising tolerance of patients towards physical tolerance test, elongation of the period of remission.

It was proved that IV LBI reduces aggregation ability of thrombocytes, activates fibrinolysis, which results in peripheral blood flow velocity increasing and tissues oxygenation enriching.

The improvement of microcirculation and utilisation of oxygen in tissues as a result of IV LBI is intimately linked with positive influence on metabolism: higher level of oxidation of energy-carrying molecules of glucose, pyruvate, and other substances.

The improvement in microcirculation system is also stipulated by vasodilation and change in rheological properties of blood as a result of drop of its viscosity, decrease of aggregation activity of erythrocytes due to changes of their physicochemical properties, in particular rising of negative electric charge.

Finally the activation of microcirculation, unblocking of capillaries and collaterals, improvement of tissue trophical activity, normalisation of a nervous excitability take place (N. N. Kapshidze et al., 1993).

IV LBI is recommended to apply before surgical operations as preparation for intervention, as well as in the postoperative stage, because the laser irradiation of blood has not only analgetic effect, but also spasmolytic and sedative activity.

IV LBI procedures on patients with chronic glomerulonephritis allow overcoming resistance towards medicament therapy (glucocorticoid, cytostatic, hypotensive and diuretic drugs).

IV LBI promotes rising of concentration of antibiotics in the focus of inflammation as a result of improvement the microcirculation in the focus of inflammation, as well as normalisation the morphology and functional activity of the affected organ as a whole.

IV LBI procedures have found broad application in obstetrics and gynecology for activation the blood flow in utero-placental and feto-placental basins, for prophylaxis of the pathologies at delivery, for influence on inflammatory processes of inner genital organs.

IV LBI normalises production of gonadotropins, improves microcirculation, elevates oxygen pressure in blood and in tissues, and so accelerates the process of regeneration and reparation.

In order to explain the generalised and multifactor effects of IV LBI, its positive influence practically on all tissues and functional systems of the body, clinical effectiveness for the treatment of different diseases, some authors mentioned that the improvement of microcirculation after IV LBI is detected in all structures of central nervous system, but this improvement is most active in the hypothalamus, which has highly developed vascular system.

The capillaries of a hypothalamus are remarkable for high permeability for macro-molecular proteins, which should even more amplify influence of the irradiated blood to subthalamic nuclei.

So it is supposed, that IV LBI increases the functional activity of hypothalamus and all limbic system, and as a result the activation of energetic, metabolism, immune and vegetative responses, mobilization of adaptive reserves of an organism is reached.



Transcutaneous Laser Blood Irradiation Therapy


The application in clinics of the non-invasive and relatively simple method of infrared (IR) transcutaneous laser irradiation of blood becomes possible after development of suitable

IR semiconductor laser diodes. For transcutaneous LBI lasers with red (630-670 nm) or near IR (800-1300 nm) irradiation band are applied. Laser light is delivered to the skin on a projection of large veins or arteries via special nozzles.

Some recent studies suggested that it is possible to achieve the medical effect similar to effect of IV HeNe LBI, without intravenous manipulations - by transcutaneous laser blood irradiation (TLBI).The procedure of TLBI has the greatest application in children's practice.

The method is founded on a relatively high permeability of the skin and hypodermic tissues for radiation of red and especially of IR spectrum.

It is supposed, that the efficacy of 20 mW HeNe laser transcutaneous blood irradiation is equal to 1 mW HeNe laser intravenous blood irradiation. In the same time TLBI procedures are non-invasive and painless.

Recently non-laser light sources are also applied for transcutaneous blood irradiation.

Unfortunately, there are not enough qualified works on comparing medical and biological effects of IV and transcutaneous LBI to make the final suggestions about clinical equality of these methods.

Brill (1994) suggested that the effects of the laser therapy depend on the method of irradiation. He considered, that the term "transcutaneous laser blood irradiation" is disorientating, as it skips the significance in definition of bioeffect of irritation of receptors of the skin and acupuncture points, dermal cells (including mast cells), aditional elements of the vascular wall and other formations, which are subject to the irradiation.

Today there are no ground to consider, that the positive therapeutic effect of laser irradiation of skin is a result of influence only of that part of energy, which penetrates the skin and is absorbed by blood and its components. With good reasons it is possible to speak about transcutaneous laser irradiation, with indication of the place of delivery of laser light.



Blue Light Blood Irradiation Therapy


Currently the methods of laser and non-laser (incoherent monochromic, narrow-band or broadband) light blood irradiation therapy - the methods of photohemotherapy - are widely applied in the treatment of different pathologies.
H. Kost et al. (1986) offered blood irradiation with incoherent narrow-band blue light for the treatment of patients with ischemic heart disease and hypertensive disease.

The drop in low-density lipoproteins and cholesterol content of the blood serum was determined. Further studies proved the broad therapeutic activity of the blue light blood irradiation procedures.

In studies of medico-biological effects of extracorporeal blue light irradiation of blood V. I. Karandashov et al. (1996, 2000) detected dropping of viscosity of blood immediately after the reinfusion.

The viscosity of the blood plasma also was reduced, but to less degree than viscosity of blood, and had correlation with concentration of blood proteins. All these have results in augmentation of flowability of blood and improvement of microcirculation.

The changes of viscosity of blood and hematocrit are determined by intravascular dilution of extravascular fluid with lower concentration of high molecular weight proteins.

After the completing the course of irradiation the viscosity of blood was always lower than it was before the treatment. The decrease of concentration of cholesterol, triglycerides, lipoproteins and glucose was also marked.

Thus, the phototherapy by blue light did not damage the blood cells, but stipulated dropping of concentration of atherogenous lipids, glucose and bilirubin.

The obtained alterations had tendency to increase and stabilisation at carrying out of a course of phototherapy. At the same time studies showed that blue light does not affect the rheological properties of the blood in vitro.

The infusion of the blood irradiated with blue light had immunostimulative activity for patients with chronic asthmatic bronchitis.

It was also shown that immediately after the infusion of irradiated blood all main parameters of respiratory function were improved, and the increasing of effect was detected during and after the course of treatment.

Blue light blood irradiation therapy presents very good results in the treatment of different pathologies. It looks like it combines the best properties of both UBI and LBI procedures. Probably in the near future the blue light blood irradiation therapy will be used much more actively, than today.


-------

There are about 75 studies from 1999 on about light & health on this website:

http://www.laserpartner.org/lasp/web/en.htm

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Marnie
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I edited my post above. It looks like the enzyme in the WFL might well be PDE1.

And I added more about which wavelength might be of greatest benefit.

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Niek
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sorry, I give up and rest my case.

apparently it is impossible to have a solid discussion about scientific facts here.

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Marnie
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Cancer: The ATP-Photon Hypothesis

(My note...the following link is very interesting)
http://www.newmediaexplorer.org/sepp/2007/08/28/cancer_the_atpphoton_hypothesis.htm

Additional:


ABSTRACT
"ATP is a key molecule in cellular metabolism. In this thesis, I examined
the effects of visible (635 and 655 nm) and near-infrared (810 and 830 nm) light
on ATP

in solution.

I also examined were the biochemical behavior of light exposed
ATP in the luciferine-luciferase reaction and hexokinase reaction, the
initial step in glycolysis that begins extra mithocondrial ATP synthesis.

Irradiated
groups in the luciferine-luciferase reaction showed an improvement in the kinetic
parameters V0 and k, and more ATP molecules reacted with the enzyme

when they were excited by light.

When irradiated ATP was added to the hexokinase
reaction, the experimental groups showed significant differences in the Michaelis-
Menten kinetic parameters (km for ATP and vmax) and the rate of product synthesis
was greater.

Changes in both reactions were wavelength and dose dependant.
When ATP was excited with UV photons, it fluoresced.

This fluorescence
decreased when Mg2+ was added, probably because the ion binds the phosphates,
which are the part of the molecule responsible for light emission.

Irradiating the
ATP-Mg2+ solution with 655 nm and 830 nm light increased the fluorescence
resulting from a displacement of charges in the phosphor-oxygen bond that repels
Mg2+.

The refraction of light in an ATP solution was observed by the Michelson
interferometer and by directly measuring the refractive index. The refractive
index changed after red and near-infrared light interaction due to a change in the
electrical permittivity of the medium.
viii

Since ATP in water is transparent to visible and near-infrared light, and is
therefore not a chromophore for those wavelengths,

I conclude that the observed
light interaction with ATP is not due to photon absorption but

to the electromagnetic disturbance produced by the light,

which leads to a polarization
of the dielectric molecule that is ATP.

This interaction of visible and near-infrared electromagnetic energy with
ATP offers new perspectives for explaining light interaction at subcellular level."

http://www.tesisenxarxa.net/TESIS_URV/AVAILABLE/TDX-0324106-130915//TESIFULLSPREVIS.pdf

Did you come to this website to exchange knowledge and ideas (2 way communication) or to to lecture (which is one way communication)?


I am disappointed you have given up helping others to learn, Niek.

I believe helping others in their time of need using whatever knowledge I have or whatever skills I have is paramount.

I believe others who have said:

Cicero: Quotes: Helping
It is our special duty, that if anyone needs our help, we should give him such help to the utmost of our power.

Johann Wolfgang Von Goethe: Quotes: Helping
Let everyone sweep in front of his own door and the whole world will be clean.

Martin Luther King, Jr.: Quotes: Helping
Life's most urgent question is: What are you doing for others?

Edward Everett Hale: Quotes: Helping
Look up and not down. Look forward and not back. Look out and not in, and lend a hand.

Euripides: Quotes: Helping
Love is all we have, the only way that each can help the other.

Helen Keller: Quotes: Helping
Many persons have a wrong idea of what constitutes true happiness. It is not attained through self gratification but through fidelity to a worthy purpose.

The Reverend Jesse Jackson, American Civil Rights Leader: Quotes: Helping
Never look down on anybody unless you're helping him up.

Thurgood Marshall: Quotes: Helping
None of us has gotten where we are solely by pulling ourselves up from our own bootstraps. We got here because somebody bent down and helped us.

Joseph B. Wirthlin: Quotes: Helping
Our friends should be companions who inspire us, who help us rise to our best.

Dalai Lama: Quotes: Helping
Our prime purpose in this life is to help others. And if you can't help them, at least don't hurt them.

****

While I may have not said it enough, I have learned a LOT from MANY people on this board and I hope whatever I have learned and shared has helped others.

I am forever grateful to you lyme patients for the knowledge YOU HAVE GIVEN TO ME.

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lymie_in_md
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quote:
Dr. Fritz-Albert Popp:

``Biological Systems are governed by the special
interaction of a coherent electromagnetic field (biophotons) and biological
matter. There is a permanent feedback coupling between field and matter
in a way that the field directs the location and activity of matter,
while matter provides the boundary conditions of the field. Since
the field is almost fully coherent, the interference patterns of the
field contain the necessary information about the regulatory function.''


Who agrees or disagrees with Professor view of communication with biophotons and matter?

If I was able to take a cube of light and within the cube put a small mirror to distort the light. The cube would no longer function as an integrated cube of light. It would be distorted. I think it up to science to be able to look at biophotons and their integration with matter in exactly this way. Biophotons are probably an indestructable holographic structure that can be distorted. One could theorize the distortion to be disease.

--------------------
Bob

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Niek
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quote:
Originally posted by Marnie:


Did you come to this website to exchange knowledge and ideas (2 way communication) or to to lecture (which is one way communication)?

I am disappointed you have given up helping others to learn, Niek.

as you seem to find it necessary to add insult, I will make myself a bit more clear: you keep adding loads of NON-science, nonsense to the thread and other remarks that may be bits of science but have nothing to do with the subject, at least not from a scientific point of view. But it is clear to me now that you don't want to hear that.

If you want to play with bits of science without adhering to the rules of science/logic, that is fine with me but then I have nothing to add to the 'discussion'. I think this thread (and some similar ones) is a good example why flash.lymenet.org is sometimes referred to as 'Lymenut' in other parts of the world. [dizzy]

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lymie_in_md
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Niek, what are your qualifications that you can insult all of us? Are you scientist of any merit or are you like the doctor from quackwatch?

You speak of science as being very important, you said that Fritz Popp doesn't like all the marketing hype. Or is that just your own opinion or have you had an actual conversation?

GiGi was in a converence with Professor Popp and Dr. Weitzel. Why would he attend such an event, if he didn't support it?

If you truly believe in science and you read the IDSA guidelines none of us have lyme. You can't always trust science, isn't that right?

By the way, a truly narrow minded person would call sick people "lymenuts". It is my opinion you owe us all an appology.

[ 23. July 2008, 08:59 PM: Message edited by: lymie_in_md ]

--------------------
Bob

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Marnie
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Niek, you said, "as you seem to find it necessary to add insult, I will make myself a bit more clear: you keep adding loads of NON-science, nonsense to the thread and other remarks that may be bits of science but have nothing to do with the subject, at least not from a scientific point of view."

First...I did not insult you as you did lyme patients. I said I was disappointed in you...that you would give up (trying to help us to learn, to understand).

Well...here are the non-scientific links I provided for discussion:

http://clinicaltrials.gov/search/open/intervention=radiotherapy

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1223309

http://cat.inist.fr/?aModele=afficheN&cpsidt=14713301

http://www.ajbrui.com/files/AJBR_10099109.pdf.

http://www.laserpartner.cz/lasp/web/en/2004/0072.htm African Journal of Biomedical Research, Vol. 10 (2007)

http://www.laserpartner.cz/lasp/web/en/2004/0072.htm

http://www.laserpartner.cz/lasp/web/en/2004/0072.htm

http://www.nature.com/emboj/journal/v25/n3/abs/7600963a.html

http://stke.sciencemag.org/cgi/content/abstract/ajpheart;292/6/H2613

http://www.peloop.com/

http://ajpheart.physiology.org/cgi/content/abstract/294/3/H1244

http://www.jem.org/cgi/content/abstract/192/7/1015

http://diabetes.diabetesjournals.org/cgi/content/abstract/db06-0495v1

http://respiratory-research.com/content/9/1/17 Respiratory Research 2008, 9:17

http://www.photizo.co.za/pdf/article_nasa.pdf.

http://www.nas.nasa.gov/About/Education/SpaceSettlement/Contest/Results/2002/Aether/Life%20Support.htm

http://www.blackwell-synergy.com/doi/abs/10.1046/j.1365-2621.2003.00717.x?journalCode=ifs

http://tinyurl.com/6dt7kv

http://cat.inist.fr/?aModele=afficheN&cpsidt=17162656

http://www.ninds.nih.gov/news_and_events/proceedings/nirs_workshop.htm (second paragraph)

http://www.medicalnewstoday.com/articles/95334.php

http://tinyurl.com/6co5cf

http://archiv.ub.uni-heidelberg.de/volltextserver/volltexte/2008/8496/pdf/Dissertation_Markus_Uhrig.pdf

http://coolcosmos.ipac.caltech.edu/cosmic_classroom/ir_tutorial/irregions.html

http://www.pnas.org/content/95/11/6097.abstract

http://cat.inist.fr/?aModele=afficheN&cpsidt=17471891

http://www.biochemj.org/bj/381/0329/bj3810329.htm

http://www.emedicine.com/ped/byname/Porphyria--Acute.htm

http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1151152&blobtype=pdf

http://www.newmediaexplorer.org/sepp/2007/08/28/cancer_the_atpphoton_hypothesis.htm

http://www.tesisenxarxa.net/TESIS_URV/AVAILABLE/TDX-0324106-130915//TESIFULLSPREVIS.pdf

Posts: 9402 | From Sunshine State | Registered: Mar 2001  |  IP: Logged | Report this post to a Moderator
sparkle7
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Some people just want to have closed minds. There's so much evidence to support using light as a healing modality.

I'm not trying to convince anyone. If they don't want to read the studies - it's up to them.

There's no need to call people names or act arrogant. There are many numerous nasty stereotypes that we could insult each other with.

I don't think that Fritz Popp wants his name on every device that's being marketed for "new age healing," etc. This was stated pretty clearly on the Dutch site I posted a while back.

http://www.iocob.nl/english-articles/biophoton-therapy-an-appraisal.html

excerpt-

But let us first quote the concern of Dr Popp related to the use of biophoton machines and the claimed indications:

We ourselves did never claim that "biophoton machines" are able at all. The living system is working with biophotons which regulate the whole cell metabolism, since the about 100 000 chemical reactions which are permanently taking place per second and per cell have to be activated by photons (according to the knowledge of biochemistry, see, for instance, the text books of biochemistry).

This requirement of a extremely high coherence within the living system EXCLUDES the possibility of manufacturing a machine with this unbelievable accuracy and capacities. Nevertheless, there are always scharlatans who believe in these miracles.

-----

I don't think this means that light doesn't work. I just think it means that Dr. Popp doesn't want his name being used all over the internet to validate every device using principles related to light without his permission.

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TX Lyme Mom
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quote:
Originally posted by Niek:
sorry, I give up and rest my case.

apparently it is impossible to have a solid discussion about scientific facts here.

Niek,
I regret that Marnie et al. have succeeded in driving you away from LymeNet because your scientific background is needed here and will be sorely missed.

If you don't mind my asking, I'd like to know what other forums you participate in so that those of us who appreciate your ideas and viewpoint can find your valuable commentaries elsewhere on the web?

(Please feel free to reply to me by PM if you do not wish to post any further remarks openly here at LymeNet. I would have PM'ed you myself, but your PM function is not activated.)

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Lonestartick
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Ditto!

Niek,

if by any chance you are still reading here, please let me know if there are any other forums where you participate. I tried to pm you yesterday, but wasn't able to. Please feel free to pm me or use my e-mail at: [email protected]

I value your input and hate to see you leave.

quote:
Originally posted by TX Lyme Mom:
quote:
Originally posted by Niek:
sorry, I give up and rest my case.

apparently it is impossible to have a solid discussion about scientific facts here.

Niek,
I regret that Marnie et al. have succeeded in driving you away from LymeNet because your scientific background is needed here and will be sorely missed.

If you don't mind my asking, I'd like to know what other forums you participate in so that those of us who appreciate your ideas and viewpoint can find your valuable commentaries elsewhere on the web?

(Please feel free to reply to me by PM if you do not wish to post any further remarks openly here at LymeNet. I would have PM'ed you myself, but your PM function is not activated.)


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canadianmama
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Hi CottonBrain,

I would think that you may have caused some toxicity with the use of the light therapy due to die off.

I too am not a scientist, but I have watched and guided a severely sick child come back to health primarily using light therapy.

I don't know what the toxic agent is, but I would think detoxing would be a great idea, and MAYBE using the light therapy again with more thought to pathogen removal and less to pain relief.

Then you would be thinking, treat, herx, detox, feel better and responding to those cycles in your body.

Good Luck!

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