Topic: The Western Fence Lizard and why 880nM works
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Go Gi Gi!!!
Here is some more PROOF:
The Western Fence Lizard has in its blood "a protein or an enzyme" that is capable of destroying the lyme pathogen. This was discovered by Dr. Robert Lane of Berkeley (California). However, we didn't know what it was that could do that (destroy Bb).
It has taken me a long time to figure out what that is.
It is rhodopsin, but it is different than the rhodopsin WE humans have.
"Vertebrate rhodopsins are able to bind the inverse agonist 11-cis-retinal but are unable to bind the agonist all-trans-retinal, indicating that vertebrate rhodopsin changed its binding ability during the course of molecular evolution.
Here, we show that unlike vertebrate rhodopsin, amphioxus rhodopsin is still able to bind the agonist all-trans-retinal.
The opsin of amphioxus rhodopsin can also bind 11-cis-retinal to form a photoreceptive pigment that can convert to a red-shifted photoproduct through cis-trans isomerization of the chromophore upon photon absorption.
***The red-shifted photoproduct is the stable G protein activating state.***
Incubation of the opsin with all-trans-retinal produces a G protein activating state that is spectroscopically and biochemically indistinguishable from the red-shifted photoproduct, indicating that the opsin possesses agonist-binding ability.
The opsin exhibits an ≈50-fold higher affinity for 11-cis-retinal than for all-trans-retinal, and mutational analyses revealed that Trp-265 situated in helix VI is important for the increase in binding affinity to 11-cis-retinal.
These properties of amphioxus rhodopsin suggest that an ancestral rhodopsin increased the affinity for 11-cis-retinal by rearrangement of a structure including Trp-265 to act as a photoreceptor.
In addition, an additional mechanism was acquired in vertebrate rhodopsin to prevent completely the binding of exogenous all-trans-retinal during molecular evolution.
***In rhodopsin, the 11-cis-retinal chromophore forms a complex with Lys296 of opsin via a protonated Schiff base. Absorption of light initiates the activation of rhodopsin by cis/trans photoisomerization of retinal.***
Crystal Structure of OspB-CT--The structure of OspB-CT
was determined to a resolution of 2.0 �. The model extends
from Ser-157 to ***Lys-296***; N-terminal residues 152-156 were
not visible in electron density.
So OUR rhodopsin/11-cis-retinal binds to Lys-296 in Bb's outer cell wall, but to go from 11-cis-retinal to all-trans-retinal...
***We need the far infrared 880nM wavelength.***
Photon transfer...specifically 2 photons.
In humans rhodopsin is linked to diabetic retinopathy and to cancer....and it is absolutely also linked to HIV-1.
Which is why this wavelength is now in gov trials - "recruiting" - to see if it will cure many diseases.
Once the cells are making more ATP (which is what happens), this will drive (extracellular) Mg back into the cells...where it will bind to ATP and then once again phosphate transfer can happen. (Bb's PKCD inhibitor is impacting phosphate transfer.)
Now...there is always more than one way to cure diseases.
Condrosulf (Rx) may work too.
Current study was performed to investigate the effects of chondroitin sulfate (CS) extracted from Styela clava tunic on TNF-alpha-induced inflammation and to elucidate the mechanism of CS on the regulation of inflammatory factors in JB6 cells.
Our results showed that CS inhibited TNF-alpha-induced NF-kappaB activation and subsequent vascular cell adhesion molecule 1 and inducible nitric oxide synthase expressions by
blocking Akt signals in JB6 cells.
(JB6 cells are endothelial/eptithelial cells.)
Our results suggest that CS may be developed as an effective anti-inflammatory agent in the future.
PMID: 18295395 Cancer Lett. 2008 Jun 8;264(1):93-100.
TABLE 1: Mechanisms of action of Chondroitin sulfate on Osteoarthritis
The spirochete binds to heparan sulfate and dermatan
sulfate on human epithelial (HeLa) cells (23) and to
decorin, a dermatan sulfate/chondroitin sulfate proteoglycan
associated with collagen fibrils.
Bb binds to chrondroitin sulfate. And we respond by triggering MMP13 = collagenase 13...which degrades collagen. MMP 13 is triggered by TNF alpha, IL 1 B and TGF B.
We normally have another protein in our joints that binds to the same proteins as Bb, but MMP13 is destroying it.
Here is what it is:
*Opticin* binds to heparin, HS, chondroitin 4-sulfate, and dermatan sulfate, the binding affinity being dependent on sulfation pattern and oligosaccharide chain length.
CONCLUSION: We demonstrated, for the first time, that opticin is expressed and produced in human articular tissues. Our data also showed that opticin in OA cartilage is degraded in a process that could be mediated by MMP-13.
As opticin may contribute towards the structural stability of cartilage,
its cleavage by MMP-13 may predispose cartilage to degeneration, particularly at the surface.
PMID: 18164633
"A fundamental ultrastructural feature shared by the spirochetal pathogens Treponema pallidum subsp. pallidum (T. pallidum) and Borrelia burgdorferi, the etiological agents of venereal syphilis and Lyme disease, respectively, is that
their most abundant membrane proteins contain covalently attached fatty acids.
***B. burgdorferi contained only phosphatidylglycerol and phosphatidylcholine.***"
Got those 2 above? Watch for them below.
"Significant increases in saturated fatty acids, unsaturated fattyacids,phosphatidylethanolamine,
***phosphatidylcholine*** and ***phosphatidylglycerol*** levels were found in response to
Akt *activation* in these cells."
In other words, Bb is triggering the activation of Akt genes in order to trigger the cholesterol pathway, etc. to make its cell wall.
IF we block Akt (gene) signals ***in the HeLa cells***, we are in essence halting the "cholesterol pathway" in those cells...which IS one of the many pathways Bb is taking.
Bb has a gene for Na-ATPase. Na is going out of the cell and then in comes glucose and amino acids (to build its cell wall).
So...ultimately what we are doing is this:
INactivating HMG CoA reductase.
We can do this 4 ways so far:
1. Mg (but hard to get it back IN the cell because it is driven by ATP and the infected cells are making far too little ATP because they are following the glycolysis pathway)
OR
2. Benicar - an arb drug to lower cholesterol. VERY high doses are needed and it can be very risky kidney wise. And yes, it has cleared lyme in one person who contacted me. This is part of the "Marshall protocol", but is, IMO...very dangerous because of the huge doses needed to work.
OR
3. Lauricidin. It is a CH4 inhibitor.
OR
4. Condrosulf. It looks like initial doses are 4 GRAMS followed by 1200mg per day.
Now...if you don't believe me:
"In a double-blind, placebo-controlled trial of 119 patients with osteoarthritis of the fingers, the group which received oral CS at 400 mg three times a day had no progression of osteoarthritis in their fingers, unlike the placebo group, who had evidence of continuing degeneration.
In a short trial, 24 patients with osteoarthritis were given CS in a single dose of 800 mg daily for 10 days. Joint aspiration revealed an increase in hyaluronic concentration and joint viscosity, and a decrease in phospholipase A2, a marker of inflammation.
Researchers also stated that the CS group displayed a decrease in collagenolytic activity. This paper demonstrated that oral administration of chondroitin sulfate reaches target tissues (synovial fluid and cartilage) at levels that can be objectively measured in less than two weeks.
The effects of chondroitin sulfate-C on type II (CII) collagen - induced arthritis in mice were evaluated. DBA/1J mice were immunized with bovine CII emulsified in Freund's complete adjuvant, followed by a booster injection 21 days later.
Chondroitin sulfate-C at doses of 100, 300 and 1000 mg/kg was administered orally once daily beginning 14 days before initial immunization.
An arthritis index and hind paw edema were examined from day 0 to day 49, when the mice were killed by ether anesthesia for histopathological examination.
The delayed-type hypersensitivity (DTH) reaction, serum anti-CII antibody titer, and histopathologic characteristics of both synovitis and destruction of articular cartilage were analyzed.
Both the arthritis index and the serum anti-CII antibody titer were reduced by treatment with chondroitin sulfate-C in a dose-dependent manner. Chondroitin sulfate-C (1000 mg/kg) significantly inhibited hind paw edema, synovitis and destruction of the articular cartilage, but not DTH reaction.
The signs and symptoms of osteoarthritis are common complaints seen in patients suffering with chronic temporomandibular disorders (TMD), specifically, internal derangements with a diagnosis of osteoarthritis.
With or without the complaints of pain and swelling, joint noises are bothersome and annoying to both the patient and at times, to those seated close to the patient during mealtime. In fact, many patients are driven to seek care by family members because of his or her TMJ noises.
For years in veterinarian medicine, glucosamine and chondroitin sulfates have been used to treat symptoms of osteoarthritis. Recently, the use of these two supplements has been recommended for human beings as well.
Reports of decreased joint noises, pain and swelling after the administration of therapeutic doses of these supplements have sparked an interest in their possible use in the treatment of osteoarthritis. This is an impressive set of studies which show that standing alone CS can help patients suffering from osteoarthritis.
Based on these studies, oral ingestion of chondroitin sulfate is safe, well tolerated, and is equally effective when taken all at once or in divided doses.
It appears that chondroitin sulfate helps patients in three ways: the first being metabolic by increasing joint viscosity; the second is in an antidegradative fashion by reducing collagenolytic activity; and the third is by reducing inflammation, which was demonstrated in the Ronca paper by showing decreased levels of phospholipase A2 in inflamed joints.
In turn, this leads to less pain, greater mobility and an apparent retardation of joint space erosion."
CD4 T cells are absolutely critical to clearing Bb.
"Furthermore, we showed that the percentages of CD4(+) cells, CD8(+) cells, and CD4(+)CD25(+) cells in the splenocytes of mice fed with CS are significantly higher than those of the control.
These findings suggest that oral intake of CS inhibits the specific IgE production and antigen-induced anaphylactic response by up-regulating regulatory T-cell differentiation, followed by down-regulating the Th2 response."
Chondroitin sulfate (CS)
PMID: 16624819
Personally...I'd hit Bb from both directions...far infrared at the 880nM wavelength to trigger the activation of rhodopsin and take Rx. Condrosulf.
Posts: 9426 | From Sunshine State | Registered: Mar 2001
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
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Marnie,
thanks so much for this article. I look forward to printing it out and taking some time with it.
Hey, it's a small thing but, over time, as others may search for "Bionic 880" - I wonder if you think it might be helpful to put the term in your headline so it will pop up in future searches - while keeping the Western Fence Lizard in, too, as my eyes pop open every time I seen them mentioned ?
lymie_in_md
Frequent Contributor (1K+ posts)
Member # 14197
posted
Marnie,
Great stuff!!! Your missing some things, MSM, you need the sulphur to displace toxins that had accumulated in the cells. A sick a body also has to displace bad metals and lower inflamation further. And you need lots of fish oil for neural regeneration, preferably mercury free. And lots of glutathione both sublingual and suppository.
In your set of one or the other, I'd choose monolaurin/lauricidin. I'm convinced it will allow the activation of all others.
Lots of detoxification herbs or tinctures to support kidneys and liver as well as binders. All the stuff coming out of the cells isn't too good in the intracellular space or mesonchyme.
A protocol for destroying biofilm.
It does make sense why the fence lizzard does so well. It is getting a large dose of 880nm everyday. It doesn't worry about UV, I wonder if UV is a difference in it's chemistry of processing rhodopsin.
-------------------- Bob Posts: 2150 | From Maryland | Registered: Dec 2007
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djf2005
Frequent Contributor (1K+ posts)
Member # 11449
posted
is there any way to isolate the product from the lizard for human consumption/injection/ect?
-------------------- "Experience is not what happens to you; it is what you do with what happens to you."
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Re: fish oil:
The response of Borrelia burgdorferi to the challenge of reactive oxygen species (ROS) is a direct result of its limited biosynthetic capabilities and
lack of biologically significant levels of intracellular Fe.
In other bacteria, the major target for oxidative damage is DNA as a consequence of the reaction of ``free'' intracellular with ROS through the Fenton reaction. Therefore, cellular defenses in these bacteria are focused on protecting this essential cellular component.
This does not seem to be the case for B. burgdorferi. In this chapter, we describe methods that were used to analyze the potential targets for ROS in B. burgdorferi.
***Surprisingly, membrane lipids (e.g., linoleic and linolenic acids) derived from host are the major target of ROS in the Lyme disease spirochete.***
ROS are targeting the Omega 3s and 6s in the outer cell walls of Bb.
It appears Bb's Osp are too similar to our own.
We have to destroy or (better yet) block the development of Bb's cell walls.
CLA maybe okay.
Re: biofilms:
J Clin Laser Med Surg, 2003 Aug, 21 - 4, 231 - 5 A preliminary investigation into light-modulated replication of nanobacteria and heart disease; Sommer AP et al.; OBJECTIVE: The purpose of this preliminary study is to evaluate the effect of various wavelengths of light on nanobacteria =NB . BACKGROUND
DATA: NB and mitochondria use light for biological processes .
NB have been described as multifunctional primordial nanovesicles with the potential to utilize solar energy for replication .
NB produce slime, a process common to living bacteria .
Slime release is an evolutionary important stress-dependent phenomenon increasing the survival chance of individual bacteria in a colony . In the cardiovascular system, stress-induced bacterial colony formation may lead to a deposition of plaque . METHODS: Cultured NB were irradiated with NASA-LEDs at different wavelengths of light: 670, 728 and 880 nm . Light intensities were about 500k Wm(-2), and energy density was 1 x 10(4) J m(-2) . RESULTS: Monochromatic light clearly affected replication of NB . Maximum replication was achieved at 670 nm .
CONCLUSIONS: The results indicate that suitable wavelengths of light could be instrumental in elevating the vitality level of NB,
***preventing the production of NB-mediated slime***,
and simultaneously increasing the vitality level of mitochondria .
The finding could stimulate the design of cooperative therapy concepts that could reduce death caused by myocardial infarcts.''
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djf2005
Frequent Contributor (1K+ posts)
Member # 11449
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this is exciting and it makes sense.
so from what i gather, the studies currently in the mix are showing that the different wavelengths (800) included can actually inhibit NB production?
so Bb can be inhibited by 880!
very nice.
almost like levaquin and other drugs that inhibit reproduction, only this would be a much less invasive and more effective long term treatment plan.
one thing i dont get though, if the 880 inhibits reproduction, wouldnt that be provoking a big herx as the bacteria are unable to replicate?
or maybe not? maybe no herx because it just stops from re producing and doesnt kill?
very interesting
derek
-------------------- "Experience is not what happens to you; it is what you do with what happens to you."
hiker53
Frequent Contributor (5K+ posts)
Member # 6046
posted
A lot of this talked about the arthritic part of lyme. Will this work for the neuro part of lyme such as the neuropathy, muscle twitches, myoclonus jerks etc?
Hiker53
-------------------- Hiker53
"God is light. In Him there is no darkness." 1John 1:5 Posts: 8931 | From Illinois | Registered: Aug 2004
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posted
Can we drink the western lizard blood? WTF!!!
It seems so simple. I will inject it into my vein.
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GiGi
Frequent Contributor (5K+ posts)
Member # 259
posted
Thank you, Marnie.
"Let There Be Light". It is light that does it - the biochemical process may or may not happen after that.
There is light in our cells. This fact was declared for the first time in 1922 by the Russian docotr, Prof. A. Gurwitsch; It was rediscovered in 1975 by others under the direction of Prof. Popp. and demonstrated clearly using the most up-to-date research methods.
According to these, the cells of all creatures emit light, albeit an extremely weak light, which is intensified during cell division, damage or cell death and extinguished when the cell dies.
Biophoton radiation of living cells isn't just an area of visible light, it serves as a sort of radio communication. The cells communicate with each other -- I have often heard said. Consequently, biological processes in plant, animal and human organisms can be controlled. This is high order coherent light, much the same as the light from a laser (Bionic is not a laser) beam and which is suitable for optimal information transfer.
Due to this high level of order, it can create order itself and activate or inhibit biochemical processes. In cancer, for instance, there is a loss of coherence and light storage capacity -- tumorous tissues irradiate differently.
Experiments have shown that healthy cells have the ability to store a lot of light; cancer cells lose their ability to store and their coherence becoming "chaotic". The ability to form a collective with other cells is also lost.
Biophotons can intervene here and create order. Light particles are responsible for all biochemical events in our body. Life without light is not pos The Bionic880 triggers immuno-modulation, regulates hormone balance and harmonizes body, mind and spirit. sible.
Every living cell - human, animal, plant - dlivers 100,000 light impulses per second. This only ends when dead. If cells are damaged, the intensity of light is less. If light is given to the damaged and weakened cells via photons, the are encouraged to regenerate themselves.
Photons are the language of the cells. Research by the three Russian scientists (Stschurin, Kasnaschejew and Michailowa) showed after more than 5000 experiments, evidence that living cells deliver messages via photons. Each cell receives some 1000 messages per second. The information is distributed with a speed of light of 300,000 kilometers per second.
Our lifestyle explains the lack of photons. I described it yesterday in a post above - eating habits, toxin accumulation, quality of food, environmental toxins, overload of emf, gases, metals, artificial light --- mercury. Add physical and emotional stress, addictions, social and job problems. We live in an environment that is highly demanding ----- "higher, faster, and farther" ---- is not always to our benefit.
Let the lizard live.
Take care.
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djf2005
Frequent Contributor (1K+ posts)
Member # 11449
posted
let the lizard live and see the light...
sounds good to me
ahaha
seriously though, if this works for the group thats in germany now, ill be going next.
it sounds too good to be true because of all the stuff i have tried but depending on their reports and the reports of some others due to go soon i will be on a flight...
god willing it is the real deal.
i know people come home "lyme free" but why do they have symptoms still? this is what bothers me about the treatment...
cheers
derek
-------------------- "Experience is not what happens to you; it is what you do with what happens to you."
GiGi
Frequent Contributor (5K+ posts)
Member # 259
posted
Some people come back with some of the problems that are not Lyme related. This treatment specifically, with the Lyme nosodes, is mainly directed at Lyme. Light alone will not do. Lyme nosodes will not resonate with heavy metals, only indirectly help push. Lyme nosodes will only indirectly attack the mold, the fungus. Light will not directly fix a dislocated bone.
There may be other factors that need to be addressed, once the Lyme bacteria is no longer a problem. The photon treatments will continue to work after the last treatment. Not all toxins are eliminated instantly in two and a half weeks. Different problems need different treatments. Many can be addressed with photons, but in a different manner, different nosodes, etc.
Lyme is a multifactorial disease. It comes with many attachments that may have to be addressed after the most belligerent one, the spirochete, has been dealt with.
Take care.
Posts: 9834 | From Washington State | Registered: Oct 2000
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djf2005
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posted
thanks gigi.
can many of the aforementioned factors that i readily agree are factors be addressed by the bionic 880?
you say your husband is using the machine for metals? so it can be used for other applications as well?
-------------------- "Experience is not what happens to you; it is what you do with what happens to you."
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
"The opsin of amphioxus rhodopsin can also bind 11-cis-retinal to form a photoreceptive pigment
that can convert to a red-shifted photoproduct through cis-trans isomerization of the chromophore upon photon absorption."
What in the WFL helps the lizard's opsin+ 11-cis-retinal to convert to All-trans-retinoic Acid (ATRA)?
Is it due to the presence of cyanophores (the blue belly) which absorb "light" (blue absorbs the red wavelength)...and many increase photon transfer.
Is it the WFL's "diet" high in formic acid?
11-cis-Retinol dehydrogenase?
ATRA (all trans retinoic acid):
"Activation of Protein Kinase C (delta symbol) by All-trans-retinoic Acid"
"The involvement of a series of microsomal cytochrome P450 (P450) isozymes in all-trans-retinoid metabolism,
including the conversion of all-trans-retinal to all-trans-retinoic acid, was previously described."
(Gotta watch the spelling...retinal/retinol)
"All-trans-retinoic acid (ATRA), a vitamin A derivative, has the ability to reverse the malignant to the normal phenotype and to inhibit cancer invasiveness and unregulated growth, and is used to treat several types of cancer."
"Expression of NADPH oxidase is induced by all-trans retinoic acid but not by phorbol myristate acetate and 1,25 dihydroxyvitamin D3 in the human promyelocytic cell line NB4 Leukemia 11,2131-2136"
"Regardless of the presence or absence of vitamin D3, ATRA was able to cause bone resorption.
In addition to examining the effect of vitamin D on ATRA-induced bone resorption under normal conditions, this effect also was studied under conditions that inhibit bone mineralization or growth by altering dietary calcium (Ca) and phosphorus (P) levels.
Changes in dietary levels of Ca and P did not affect the ability of ATRA to cause bone resorption. Interestingly, despite its ability to stimulate bone resorption, ATRA did not affect serum calcium or phosphorus levels. Overall, the ability of ATRA to cause bone resorption is not dependent on vitamin D3, dietary Ca or dietary P."
"Topical Pretreatment of Diabetic Rats With All-trans Retinoic Acid Improves Healing of Subsequently Induced Abrasion Wounds "
"All-trans-retinoic acid (atRA) is a promising anticancer and antiwrinkle drug. However, its clinical application is limited because
it is rapidly metabolized by the induced cytochrome P450 (P450).
BUT... In this study, farnesol derivatives are proposed as new inhibitors to prevent P450-mediated metabolism."
Monoterpenes consist of two isoprene units and have the molecular formula C10H16. Examples of monoterpenes are: geraniol, *limonene* and terpineol.
Sesquiterpenes consist of three isoprene units and have the molecular formula C15H24. Examples of sesquiterpenes are: *farnesol*. The sesqui- prefix means one and a half.
"Farnesol is widely distributed in many essential oils such as citronella, neroli, cyclamen, ***lemon grass***, tuberose, rose, musk, and balsam."
You can buy lemon grass at a health food store and snip a bit and sprinkle it on a salad. It is very very healthy.
A brand new Sesquiterpene was just discovered:
From Wine to Pepper: Rotundone, an Obscure Sesquiterpene, Is a Potent Spicy Aroma Compound"
Do you juice oranges and lemons? There is an oil in the rind...
Orange and lemon peel both contain a molecule called limonene. However, the limonene molecule in orange peel has a different structure than the limonene in lemon peel. The different structures have different smells.
Orange Lemon (+) limoneme (-) limonene
The types of limonene in oranges and lemons are mirror molecules. The molecule in the orange is "left-handed," and the one in the lemon is the "right-handed" version.
What are the potential health benefits of Limonene?
Being a solvent of cholesterol,
d-limonene has been used clinically to dissolve cholesterol-containing gallstones. Because of its gastric acid neutralizing effect and its support of normal peristalsis, it has also been used for relief of heartburn and gastroesophageal reflux (GERD). D-limonene has well-established chemopreventive activity against many types of cancer.
Evidence from a phase I clinical trial demonstrated a partial response in a patient with breast cancer and stable disease for more than six months in three patients with colorectal cancer.
SOURCE Sun J. D-Limonene: safety and clinical applications. Altern Med Rev. 2007 Sep;12(3):259-64
[2] Whysner J, Williams GM. d-limonene mechanistic data and risk assessment: absolute species-specific cytotoxicity, enhanced cell proliferation, and tumor promotion. Pharmacol Ther. 1996;71(1-2):127-36
This article can not be used as medical advice. Please, consult with your medical doctor for any question or before taking any drug products and supplements.
That does not mean you can't get an electric juicer and make that morning glass of "sunshine" the FRESH kind...with a tad of d limonene from the rind of that orange as you pressed it against the juicer.
You will get more juice if the oranges are at room temperature.
Juicers do not have to be expensive...mine is a Juicit by Proctor Silex...is electric...and has worked great for many years.
This pathogen attacks the endothelial/epithelial cells that line our blood vessels...and those are everywhere.
"H16" = the "group" that relates to vascular damage.
I think even when an infection is gone, it still takes awhile for the body to rebalance. Obviously, it could use some help...eat healthy, some sunshine, fresh air, clean healthy water, exercise as tolerated and healing sleep.
I believe a LOT of the damage IS reversible...given time. Even brain cells can regenerate and heal damaged areas.
Did anyone catch the news re: to magnets approved to cure depression?
We are entering a new age...lightwaves, soundwaves, magnets...to heal.
[ 22. October 2008, 12:11 AM: Message edited by: Marnie ]
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clairenotes
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I am not so familiar with Edgar Cayce and/or his work, but my husband informed me that he was a bit psychic. One prediction he made before his death was that healing will ultimately come in the form of light.
And on a more mundane, but still somewhat interesting note, my daughter reminded me of a dream she had a few years ago where a man on a hill in France was shining a light down upon the world killing all of the 'bad bugs.' The country was slightly off, but still fairly close.
Thanks to both Gigi and Marnie for all of your hard work.
Claire
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