Please Explain the Difference between being tested and the test shows Band 23 Positive instead of Band 23-25 Positive ?
I am tested positive for just band 23 in addition to a low CD57 count of 44
(I was also tested with high numbers of hhv6 and high numbers of EBV)
After lots of reading, I clearly see the always mention of Band 23-25 to be Lyme Specific.
Does that relate to all three bands into one, band 23, 24 and 25 ?
Is there even a band 24 for that matter ?
But what about just the Band 23 all alone ?
What does that mean ???
The infection is low ?
The infection is insignificant enough to be Lyme related ?
The test is inconclusive ?
The test was not done right or in a timely manner ?
This is defintely Lyme, and it is a Tick bite from either a very long time ago, or vice versa, a very recent infection ???
There is no reason for treatment or treatment still required ?
Any Other Reasons or Actual Facts ???
I am very confused by this...
Please Help and Clarify this.
Best Regards, Eric
[ 06. January 2009, 04:42 AM: Message edited by: eric555 ]
Posts: 570 | From philadelphia, pa | Registered: Dec 2008
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You need to understand what a Western Blot (WB) measures, and the definition of a "band".
The WB measures the amount of antibodies your body makes (of 2 types- IgM and IgG) in response to certain proteins a bacteria makes. Those proteins are differentiated by their molecular weights (measured in kilodaltons - i.e Kda).
To be considered "positive" to any of the singular proteins (also called BANDS) , you must have enough antibodies to reach a predetermined saturation threshold on the WB test.
So- for example.. positive to Band 39 on the WB test means that your body produced enough antibodes to Bacterial Membrane Protein 39 ( Bmp 39 Kda ) to saturate a test strip and be deemed a POSITIVE BAND.
Some of the proteins Lyme expresses, are so close to each other in their molectuar weight, that the WB can't differentiate between them, so they are tested for together. Hense band 23-25 are the molecular weights of 23, 24 and 25 Kda.
By the way. Band 23-25 is Outer Surface Protein C (Osp C) and it is HIGHLY specific for Lyme.. meaning no other bacteria expresses this protein. So if you have antibodies to this protein. There's no doubt you have Lyme.