LymeNet Home LymeNet Home Page LymeNet Flash Discussion LymeNet Support Group Database LymeNet Literature Library LymeNet Legal Resources LymeNet Medical & Scientific Abstract Database LymeNet Newsletter Home Page LymeNet Recommended Books LymeNet Tick Pictures Search The LymeNet Site LymeNet Links LymeNet Frequently Asked Questions About The Lyme Disease Network LymeNet Menu

LymeNet on Facebook

LymeNet on Twitter




The Lyme Disease Network receives a commission from Amazon.com for each purchase originating from this site.

When purchasing from Amazon.com, please
click here first.

Thank you.

LymeNet Flash Discussion
Dedicated to the Bachmann Family

LymeNet needs your help:
LymeNet 2020 fund drive


The Lyme Disease Network is a non-profit organization funded by individual donations.

LymeNet Flash Post New Topic  New Poll  Post A Reply
my profile | directory login | register | search | faq | forum home

  next oldest topic   next newest topic
» LymeNet Flash » Questions and Discussion » Medical Questions » Doxy reduces potency of Mepron??

 - UBBFriend: Email this page to someone!    
Author Topic: Doxy reduces potency of Mepron??
kreynolds
Frequent Contributor (1K+ posts)
Member # 15117

Icon 5 posted      Profile for kreynolds     Send New Private Message       Edit/Delete Post   Reply With Quote 
Hey,

Someone had mentioned this to me the other day. They had said that Doxy reduces the potency of

Mepron by up to 40%! Since I am on IV Doxy I wanted to know if anyone knew about this because

I sure didn't...

Thanks!

--------------------
Diagnosed CDC + 6/2007

Quest: + IGG Bands 18,23,39,41,58,66 and 93.

Quest: + IGM Bands
23,39

Quest: + Bartonella (B.Henselea & B. Quintana),+ Babesia, and + Mycoplasma and Lyme-Induced Addisons Disease

+ Biofilm blood test 12/2010

Posts: 1185 | From New York | Registered: Apr 2008  |  IP: Logged | Report this post to a Moderator
TerryK
Frequent Contributor (5K+ posts)
Member # 8552

Icon 1 posted      Profile for TerryK     Send New Private Message       Edit/Delete Post   Reply With Quote 
Yes, it's true according to the manufacturer pharmacist. Cactus called them too and so did one other person so at least 3 of us have been told this by the mfg.

I'm pretty sure I read it in the babesia book too.

Terry

Posts: 6282 | From Oregon | Registered: Jan 2006  |  IP: Logged | Report this post to a Moderator
kreynolds
Frequent Contributor (1K+ posts)
Member # 15117

Icon 1 posted      Profile for kreynolds     Send New Private Message       Edit/Delete Post   Reply With Quote 
Wow... Is there anyway around it???

--------------------
Diagnosed CDC + 6/2007

Quest: + IGG Bands 18,23,39,41,58,66 and 93.

Quest: + IGM Bands
23,39

Quest: + Bartonella (B.Henselea & B. Quintana),+ Babesia, and + Mycoplasma and Lyme-Induced Addisons Disease

+ Biofilm blood test 12/2010

Posts: 1185 | From New York | Registered: Apr 2008  |  IP: Logged | Report this post to a Moderator
TerryK
Frequent Contributor (5K+ posts)
Member # 8552

Icon 1 posted      Profile for TerryK     Send New Private Message       Edit/Delete Post   Reply With Quote 
I'm pretty sure there isn't. Increasing mepron may help but I don't think it helps much. Something about diminishing returns with increased doses of mepron according to the babs book but that is a general statement and not specific to this situation.

Your LLMD may have some ideas or may decide that they should still be precribed together.

Terry

Posts: 6282 | From Oregon | Registered: Jan 2006  |  IP: Logged | Report this post to a Moderator
kreynolds
Frequent Contributor (1K+ posts)
Member # 15117

Icon 1 posted      Profile for kreynolds     Send New Private Message       Edit/Delete Post   Reply With Quote 
Thanks for your help...

Wow I'm bummed now. I take 1500mg a day of

Mepron. Now i suppose the turnout is much

less....

[ 03-17-2009, 01:58 PM: Message edited by: Kreynolds ]

--------------------
Diagnosed CDC + 6/2007

Quest: + IGG Bands 18,23,39,41,58,66 and 93.

Quest: + IGM Bands
23,39

Quest: + Bartonella (B.Henselea & B. Quintana),+ Babesia, and + Mycoplasma and Lyme-Induced Addisons Disease

+ Biofilm blood test 12/2010

Posts: 1185 | From New York | Registered: Apr 2008  |  IP: Logged | Report this post to a Moderator
AliG
Frequent Contributor (1K+ posts)
Member # 9734

Icon 1 posted      Profile for AliG     Send New Private Message       Edit/Delete Post   Reply With Quote 
You can ask LLMD to check your blood levels of Mepron & adjust the dose, if needed.

GSK published the interaction in the prescribing info for Malarone. They didn't know about it when they wrote up the Rx info for Mepron, but the interaction is definitely between atovaquone (Mepron) and tetracyclines. I confirmed this with their Scientific Research Department.

I complained to both GSK & the FDA about the fact that they didn't update the Rx info for Mepron to include that very important information. I don't know if it made any difference.

--------------------
Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner.

Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006  |  IP: Logged | Report this post to a Moderator
AliG
Frequent Contributor (1K+ posts)
Member # 9734

Icon 1 posted      Profile for AliG     Send New Private Message       Edit/Delete Post   Reply With Quote 
I'm wondering if the interaction would still occur when Doxy is administered IV, as opposed to orally.

Could you call your pharmacist & ask if the impact of the interaction would be different?

--------------------
Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner.

Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006  |  IP: Logged | Report this post to a Moderator
kreynolds
Frequent Contributor (1K+ posts)
Member # 15117

Icon 1 posted      Profile for kreynolds     Send New Private Message       Edit/Delete Post   Reply With Quote 
AliG:

Thanks for your replies...

I will call the pharmacy, but they will probably tell me to just call my doctor.

The only problem with that is he is only in the office 2 days a week and he is very hard to get in touch with.

--------------------
Diagnosed CDC + 6/2007

Quest: + IGG Bands 18,23,39,41,58,66 and 93.

Quest: + IGM Bands
23,39

Quest: + Bartonella (B.Henselea & B. Quintana),+ Babesia, and + Mycoplasma and Lyme-Induced Addisons Disease

+ Biofilm blood test 12/2010

Posts: 1185 | From New York | Registered: Apr 2008  |  IP: Logged | Report this post to a Moderator
AliG
Frequent Contributor (1K+ posts)
Member # 9734

Icon 1 posted      Profile for AliG     Send New Private Message       Edit/Delete Post   Reply With Quote 
Let me know if you can't get an answer from your pharmacist.

Usually, if they know their stuff, they like to be able to answer questions.

I get better info from my pharmacist when it comes to the specifics on interactions. They also understand that they are often reachable when doctors aren't.

Answering interaction questions on Rxs that they fill, is part of their job.

--------------------
Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner.

Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006  |  IP: Logged | Report this post to a Moderator
kreynolds
Frequent Contributor (1K+ posts)
Member # 15117

Icon 1 posted      Profile for kreynolds     Send New Private Message       Edit/Delete Post   Reply With Quote 
I called the pharmacy and they seemed confused...

The funny thing is my doctor never said a word about it.

Thanks for your help!

--------------------
Diagnosed CDC + 6/2007

Quest: + IGG Bands 18,23,39,41,58,66 and 93.

Quest: + IGM Bands
23,39

Quest: + Bartonella (B.Henselea & B. Quintana),+ Babesia, and + Mycoplasma and Lyme-Induced Addisons Disease

+ Biofilm blood test 12/2010

Posts: 1185 | From New York | Registered: Apr 2008  |  IP: Logged | Report this post to a Moderator
Abxnomore
Frequent Contributor (5K+ posts)
Member # 18936

Icon 1 posted      Profile for Abxnomore     Send New Private Message       Edit/Delete Post   Reply With Quote 
Pharmacists often know way more than doctors about drug interactions. That is their job. Try another pharmacist. Anyone will help. It doesn't necessarily have to be one that you use.
Posts: 5187 | From Lyme Zone | Registered: Jan 2009  |  IP: Logged | Report this post to a Moderator
Abxnomore
Frequent Contributor (5K+ posts)
Member # 18936

Icon 1 posted      Profile for Abxnomore     Send New Private Message       Edit/Delete Post   Reply With Quote 
It says so right here http://www.drugs.com/cdi/mepron.html Call the company's number, GlaxoSmithKline, and ask them directly. They will have an 800 number for consumer questions.
Posts: 5187 | From Lyme Zone | Registered: Jan 2009  |  IP: Logged | Report this post to a Moderator
kreynolds
Frequent Contributor (1K+ posts)
Member # 15117

Icon 1 posted      Profile for kreynolds     Send New Private Message       Edit/Delete Post   Reply With Quote 
Abxnomore:

Thanks for the info and the link. I will call them.

--------------------
Diagnosed CDC + 6/2007

Quest: + IGG Bands 18,23,39,41,58,66 and 93.

Quest: + IGM Bands
23,39

Quest: + Bartonella (B.Henselea & B. Quintana),+ Babesia, and + Mycoplasma and Lyme-Induced Addisons Disease

+ Biofilm blood test 12/2010

Posts: 1185 | From New York | Registered: Apr 2008  |  IP: Logged | Report this post to a Moderator
kreynolds
Frequent Contributor (1K+ posts)
Member # 15117

Icon 1 posted      Profile for kreynolds     Send New Private Message       Edit/Delete Post   Reply With Quote 
on the phone now....(GlaxoSmithKline)

--------------------
Diagnosed CDC + 6/2007

Quest: + IGG Bands 18,23,39,41,58,66 and 93.

Quest: + IGM Bands
23,39

Quest: + Bartonella (B.Henselea & B. Quintana),+ Babesia, and + Mycoplasma and Lyme-Induced Addisons Disease

+ Biofilm blood test 12/2010

Posts: 1185 | From New York | Registered: Apr 2008  |  IP: Logged | Report this post to a Moderator
kreynolds
Frequent Contributor (1K+ posts)
Member # 15117

Icon 1 posted      Profile for kreynolds     Send New Private Message       Edit/Delete Post   Reply With Quote 
she said " There is no record of this drug interacting with Doxycycline."

I explained to her that I have "googled" it and it does show a reduced potency.

She then told me to call the manufacturer of the Doxy.....

--------------------
Diagnosed CDC + 6/2007

Quest: + IGG Bands 18,23,39,41,58,66 and 93.

Quest: + IGM Bands
23,39

Quest: + Bartonella (B.Henselea & B. Quintana),+ Babesia, and + Mycoplasma and Lyme-Induced Addisons Disease

+ Biofilm blood test 12/2010

Posts: 1185 | From New York | Registered: Apr 2008  |  IP: Logged | Report this post to a Moderator
TerryK
Frequent Contributor (5K+ posts)
Member # 8552

Icon 1 posted      Profile for TerryK     Send New Private Message       Edit/Delete Post   Reply With Quote 
So you called the mfg of mepron and they said there is no interaction?? ugh!!

Here are my notes from my conversation with the pharmacist around August of 2007. You could try to call the pharmacist at the number in my notes.

I called and talked to Dawn, a pharmacist at GlaxoSmithKline. She said that the use of Doxy with Mepron could reduce mepron blood levels by as much as 40%. I can get in touch with her at 1-888-825-5249 - she is the only Dawn there. It is not listed in the Mepron prescribing info but it is in the Malarone info.

I think Alig has a good idea. Ask your LLMD to take your blood levels so that you can ensure that you are on a theraputic dose.

Terry

Posts: 6282 | From Oregon | Registered: Jan 2006  |  IP: Logged | Report this post to a Moderator
kreynolds
Frequent Contributor (1K+ posts)
Member # 15117

Icon 1 posted      Profile for kreynolds     Send New Private Message       Edit/Delete Post   Reply With Quote 
TerryK:

Yes I just spoke to her. I'll have my Doc check my blood levels.

Seems like the only way to see if there is a fluctuation...

Thanks for all your help!

--------------------
Diagnosed CDC + 6/2007

Quest: + IGG Bands 18,23,39,41,58,66 and 93.

Quest: + IGM Bands
23,39

Quest: + Bartonella (B.Henselea & B. Quintana),+ Babesia, and + Mycoplasma and Lyme-Induced Addisons Disease

+ Biofilm blood test 12/2010

Posts: 1185 | From New York | Registered: Apr 2008  |  IP: Logged | Report this post to a Moderator
kreynolds
Frequent Contributor (1K+ posts)
Member # 15117

Icon 1 posted      Profile for kreynolds     Send New Private Message       Edit/Delete Post   Reply With Quote 
Seems like they don't know what there selling... bunch of morons!!

--------------------
Diagnosed CDC + 6/2007

Quest: + IGG Bands 18,23,39,41,58,66 and 93.

Quest: + IGM Bands
23,39

Quest: + Bartonella (B.Henselea & B. Quintana),+ Babesia, and + Mycoplasma and Lyme-Induced Addisons Disease

+ Biofilm blood test 12/2010

Posts: 1185 | From New York | Registered: Apr 2008  |  IP: Logged | Report this post to a Moderator
kreynolds
Frequent Contributor (1K+ posts)
Member # 15117

Icon 1 posted      Profile for kreynolds     Send New Private Message       Edit/Delete Post   Reply With Quote 
Seems like they don't know what there selling... bunch of morons!!

--------------------
Diagnosed CDC + 6/2007

Quest: + IGG Bands 18,23,39,41,58,66 and 93.

Quest: + IGM Bands
23,39

Quest: + Bartonella (B.Henselea & B. Quintana),+ Babesia, and + Mycoplasma and Lyme-Induced Addisons Disease

+ Biofilm blood test 12/2010

Posts: 1185 | From New York | Registered: Apr 2008  |  IP: Logged | Report this post to a Moderator
jocus20
LymeNet Contributor
Member # 11576

Icon 1 posted      Profile for jocus20     Send New Private Message       Edit/Delete Post   Reply With Quote 
My doc uses doxy/mino with merpon or malarone and has found no decrease in effectiness.

--------------------
http://www.myspace.com/jocus20

also check out my videos:

http://www.youtube.com/user/jocus20

Posts: 247 | From PA | Registered: Apr 2007  |  IP: Logged | Report this post to a Moderator
kreynolds
Frequent Contributor (1K+ posts)
Member # 15117

Icon 1 posted      Profile for kreynolds     Send New Private Message       Edit/Delete Post   Reply With Quote 
jocus20:

Thanks for your input... I have been getting mixed answers...

--------------------
Diagnosed CDC + 6/2007

Quest: + IGG Bands 18,23,39,41,58,66 and 93.

Quest: + IGM Bands
23,39

Quest: + Bartonella (B.Henselea & B. Quintana),+ Babesia, and + Mycoplasma and Lyme-Induced Addisons Disease

+ Biofilm blood test 12/2010

Posts: 1185 | From New York | Registered: Apr 2008  |  IP: Logged | Report this post to a Moderator
tosho
LymeNet Contributor
Member # 10191

Icon 1 posted      Profile for tosho     Send New Private Message       Edit/Delete Post   Reply With Quote 
Yes, doxycycline reduces effectiveness of Mepron.

http://www.lymepa.org/html/dr__j__burrascano_september_20_15.html

"Concurrent tetracyclines (tetracycline, doxycycline, minocycline) are not compatible with atovaquone"

(atovaquone is Mepron)

But sometimes LLMDs give doxy/mino with Mepron and find it effective.
I think the only problem may be for people who have difficult/resistant cases of Babesia, when you need to be sure that there is no decreased concentration of Mepron.

--------------------
[Bb WB igm+] [B.henselae PCR+] [Chlamydia pneum.igm+igg+] [EBV igm-igg+]

Posts: 844 | From Poland | Registered: Sep 2006  |  IP: Logged | Report this post to a Moderator
kreynolds
Frequent Contributor (1K+ posts)
Member # 15117

Icon 1 posted      Profile for kreynolds     Send New Private Message       Edit/Delete Post   Reply With Quote 
When I called GlaxoSmithKline the manufacturer of Mepron, they said no.

I have researched and it says it does... [bonk]

--------------------
Diagnosed CDC + 6/2007

Quest: + IGG Bands 18,23,39,41,58,66 and 93.

Quest: + IGM Bands
23,39

Quest: + Bartonella (B.Henselea & B. Quintana),+ Babesia, and + Mycoplasma and Lyme-Induced Addisons Disease

+ Biofilm blood test 12/2010

Posts: 1185 | From New York | Registered: Apr 2008  |  IP: Logged | Report this post to a Moderator
   

Quick Reply
Message:

HTML is not enabled.
UBB Code is enabled.

Instant Graemlins
   


Post New Topic  New Poll  Post A Reply Close Topic   Feature Topic   Move Topic   Delete Topic next oldest topic   next newest topic
 - Printer-friendly view of this topic
Hop To:


Contact Us | LymeNet home page | Privacy Statement

Powered by UBB.classic™ 6.7.3


The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:

The Lyme Disease Network of New Jersey
907 Pebble Creek Court, Pennington, NJ 08534 USA


| Flash Discussion | Support Groups | On-Line Library
Legal Resources | Medical Abstracts | Newsletter | Books
Pictures | Site Search | Links | Help/Questions
About LymeNet | Contact Us

© 1993-2020 The Lyme Disease Network of New Jersey, Inc.
All Rights Reserved.
Use of the LymeNet Site is subject to Terms and Conditions.