Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
There was a short video on our TV news last night at 11pm (Sarasota area) with Michael J Fox playing golf with another Parkinson's patient he had met and become friends with.
The newscaster said the other man (large, wearing a red golf shirt) HAD LYME a number of years ago and was treated and now had Parkinson's...
It is my understanding that when dopamine levels drop, not only does serotonin (which converts to melatonin - an anti-oxidant) go up, but also prolactin is released in the brain.
About 2 years ago, researchers found that prolactin, given to mice to were engineered to have MS, spontaneously restored the myelin sheath (the insulation around our nerves).They were shocked and supposedly prolactin use was going into immediate human trials.
Looks to me like the dopamine drop is a body defense move (increasing anti-oxidant and protecting the myelin sheath) - at the cost of Parkinson's symptoms.
Tough "choice"...Parkinson's symptoms (low dopamine) or MS (no myelin sheath).
I wonder if the choice is because of melatonin's multiple functions primarily?
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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Besides dopamine, look at the mention of NaCl and the mention of GABA.
GABA comes FROM glutamate (= glutamic acid) and Bb metabolizes glutatmate (and alanine).
Bb uses Na-ATPase and
uses NaCl for motility (Bb's flagella are "hidden")
...did you read what I read in the above link re NaCl?!
Many of our addictions (including food) are linked to dopamine receptors (there are 5). We can be genetically "predisposed" to addictions.
Doubt? "Google" the words: obesity dopamine. You will see that specific RECEPTORS are involved.
Besides having enough of a neurotransmitter, we have to have WORKING RECEPTORS which the neurotransmitters lock onto. That's where/why many of the problems "happen".
Get this: exercise increases the number of dopamine receptors and alters our gene expression (positively).
GABA A and GABA C are chloride channels and are inhibited via the use of Frontline for our dogs to *prevent* lyme.
GABA B is not a chloride channel.
GABA A and GABA C are *fast* inhibition, GABA B is *slow* inhibition.
Chloride channels...turn them off/block?
One of the treatments for MS involves a drug that is supposed to help GABA B. It helps, but doesn't cure.
You see there are 2 protein helpers: Gi and Go that are needed to make/activate GABA B. And one of them has to happen first. They both are needed. The MS drug doesn't help BOTH G protein forms.
"The dopamine transporter constitutively internalizes and recycles in a protein kinase C regulated manner in stably transfected PC12 cell lines"
SUMMARY
The dopamine transporter (DAT) removes dopamine from the extracellular milieu and is potently inhibited by number of psychoactive drugs, including cocaine, amphetamines and methylphenidate (Ritalin).
Multiple lines of evidence demonstrate that protein kinase C (PKC) downregulates dopamine transport,
primarily by redistributing DAT from the plasma membrane to endosomal compartments, although the mechanisms facilitating transporter sequestration are not defined."
Is Bb's PKC inhibitor UPregulating dopamine transport?
Could your mind benefit by Ritalin ER (extended release)?
I have a son with low sodium triggered seizures, ADHD, etc. and I am finding this FASCINATING!
Posts: 9481 | From Sunshine State | Registered: Mar 2001
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