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» LymeNet Flash » Questions and Discussion » Medical Questions » Albendizole for Cysts?

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Author Topic: Albendizole for Cysts?
4Seasons
LymeNet Contributor
Member # 14601

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My LLMD just put me on Albendizole for the cyst form of lyme.

I know it is usually an anti-parasitic, that is not an issue for me.

We have eliminated oral abx for now, due to candida problems.

I can't find any info about using this medicine for the cyst form. Can anybody refer me to any info about it?

(I was on Tindamax before the candida flared and am now on IM Bicillin)

Thanks!

--------------------
"Life isn't about waiting for the storm to pass, it's about learning to dance in the rain."
Anonymous

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lymeberry
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Google it - there is another spelling

http://flash.lymenet.org/ubb/Forum1/HTML/033338.html

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lymeberry
Unregistered


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Albendazole

List of ****dazole's that I have found
tinidazole, metronidazole,

nitroimidazoles,secnidazole,quinacrine, furazolidone, ornidazole,benzimidazole, albendazole,mebendazole,
nocodazole,oxfendazole,
thiabendazole,fenbendazole.

An In Vitro Study of the Susceptibility of Mobile and Cystic Forms
of Borrelia burgdorferi to Metronidazole

Date of Publication:

June, 1999
Source:

APMIS, 107(6):566-576
Authors:
(1) Brorson O; (2) Brorson S.
Institution:
(1) Department of Microbiology, Vestfold Sentralsykehus, Tonsberg
(2) Department of Pathology, Ulleval Hospital, Oslo, Norway
Abstract

The aim of this study was to examine the susceptibility of mobile and cystic forms of Borrelia burgdorferi
to metronidazole. Because B. burgdorferi is a microaerobic bacterium like Helicobacter pylori,
metronidazole (MZ) was chosen in the susceptibility test. For both microaerobic and aerobic incubation
the normal mobile spirochetes were resistant to this antibiotic with an MBC >=512 [micro]g/ml.

Conversion of mobile spirochetes to cystic forms was not observed when they were incubated with MZ.

When they were incubated under microaerobic conditions, the biologically active cystic forms had an
MBC >=4 [micro]g/ml, but the MBC was >=32 [micro]g/ml with aerobic incubation at 37[degrees]C.

Staining with acridine orange (AO), dark field microscopy (DFM), and transmission electron microscopy
(TEM) revealed that the contents of the cysts were degraded when the concentration of MZ was >=MBC.

Some cysts were also ruptured. When incubated with a sufficient concentration of MZ, core structures did
not develop inside the cysts, and AO revealed less RNA in the cysts.

Our observations may help efforts
to treat resistant infections caused by B. burgdorferi with a combination of MZ and other
antibiotics in order to eradicate both cystic and mobile forms of B. burgdorferi.
------------------------------------
Quotations From The Full-Text Article
``Serology, PCR, and cultivation are important for the conclusive diagnosis of Lyme borreliosis, but all
these techniques have shortcomings, and false-positive and false-negative results are frequent.
Many
reports claim that all known antibiotics have shortcomings in the treatment of Lyme borreliosis.

B. burgdorferi has the ability to make cystic forms both in vivo and in vitro, e.g. when exposed to
antibiotics commonly used for treating Lyme borreliosis.

This phenomenon, combined with the
ability of the cysts to reconvert to normal mobile spirochetes may explain a reactivation of the disease after an illusory cure - and not a ``post Lyme syndrome'' as postulated by other
researchers.''
(p.566)

``Helicobacter pylori is also [like B. burgdorferi] capable of transforming to coccoid (cystoid) forms
and reversing to normal mobile forms, and for this bacterium treatment with three or more antibiotics has been established.

Therefore duel medication with MZ [metronidazole] as one of the antibiotics could be of value, also for curing infections caused by mobile and cystic forms of B.
burgdorferi.

BRORSON's Work on Borrelia burgdorferi

Theres a list for yins

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nellypointis
LymeNet Contributor
Member # 1719

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quote:
Originally posted by 4Seasons:
My LLMD just put me on Albendizole for the cyst form of lyme.
I can't find any info about using this medicine for the cyst form. Can anybody refer me to any info about it?

Yes, it's albendazole, and I don't think you will find any info related to using albendazole for cyst forms of Bb.

I am also taking albendazole and I am finding it is definitely helping me a lot with my gut symptoms as well as giving me (when I first took it or when I re-take it after a break) the same kind of monster headaches that the nitroimidazoles give me.

Brain clearer after albendazole (// tinidaole for me), but in my case I strongly parasites to be an issue

btw: when I used flubendazole (very similar to albendazole) I sprouted crops of what looked like (and behaved like ie spredaing outwards) secondary EM rashes, so I think the flubendazole either dislodged Bb that were sequestred in Bb cysts or in parasitic unidentified objects

Nelly

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Pinelady
Frequent Contributor (5K+ posts)
Member # 18524

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Well where do you sign up?

--------------------
Suspected Lyme 07 Test neg One band migrating in IgG region
unable to identify.Igenex Jan.09IFA titer 1:40 IND
IgM neg pos
31 +++ 34 IND 39 IND 41 IND 83-93 +
DX:Neuroborreliosis

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