LymeNet Home LymeNet Home Page LymeNet Flash Discussion LymeNet Support Group Database LymeNet Literature Library LymeNet Legal Resources LymeNet Medical & Scientific Abstract Database LymeNet Newsletter Home Page LymeNet Recommended Books LymeNet Tick Pictures Search The LymeNet Site LymeNet Links LymeNet Frequently Asked Questions About The Lyme Disease Network LymeNet Menu

LymeNet on Facebook

LymeNet on Twitter




The Lyme Disease Network receives a commission from Amazon.com for each purchase originating from this site.

When purchasing from Amazon.com, please
click here first.

Thank you.

LymeNet Flash Discussion
Dedicated to the Bachmann Family

LymeNet needs your help:
LymeNet 2020 fund drive


The Lyme Disease Network is a non-profit organization funded by individual donations.

LymeNet Flash Post New Topic  New Poll  Post A Reply
my profile | directory login | register | search | faq | forum home

  next oldest topic   next newest topic
» LymeNet Flash » Questions and Discussion » Medical Questions » Can Babesia cause temporarily high iron levels? Please help!

 - UBBFriend: Email this page to someone!    
Author Topic: Can Babesia cause temporarily high iron levels? Please help!
Stefan
LymeNet Contributor
Member # 19150

Icon 1 posted      Profile for Stefan     Send New Private Message       Edit/Delete Post   Reply With Quote 
I went through my old bloodwork and found two tests where the iron was to high.

Other tests for iron were absolutely normal.

I don t have haemochromatosis.

Can Babesia cause temporarily high iron levels?

Like when the red blood plates get destroyed that a bigger amount of iron is circulating?

At the moment I am only taking bactrim and this is what helped me most so far.

My MCH and MCV are also elevated - a sign for babesiosis?

I have the drenching night sweats, dark urine, air hunger as well.

But I have no lyme. Only CPN and Bartonella.

Clindamycin and Tinidazole were also good.

Please help

Posts: 188 | From Germany | Registered: Feb 2009  |  IP: Logged | Report this post to a Moderator
Stefan
LymeNet Contributor
Member # 19150

Icon 1 posted      Profile for Stefan     Send New Private Message       Edit/Delete Post   Reply With Quote 
My LDH and CK are also sometimes high when i feel bad. And my liver enzymes go up as well.
Posts: 188 | From Germany | Registered: Feb 2009  |  IP: Logged | Report this post to a Moderator
DaveinCt
LymeNet Contributor
Member # 5818

Icon 1 posted      Profile for DaveinCt   Author's Homepage     Send New Private Message       Edit/Delete Post   Reply With Quote 
Interesting....my Ferritin level tends to be on the high side...Last test was 347 with normal being below 300, I think.

Anyway, I also recently was diagnosed with Babs (Duncani)and wonder if there's any correlation.

--------------------
Thx,
Dave (Now in VA.)

Posts: 207 | From Lynchburg, VA. | Registered: Jun 2004  |  IP: Logged | Report this post to a Moderator
Lymeorsomething
Frequent Contributor (1K+ posts)
Member # 16359

Icon 1 posted      Profile for Lymeorsomething     Send New Private Message       Edit/Delete Post   Reply With Quote 
Dave rule out hemochromatosis too. Those levels seem a little high....

--------------------
"Whatever can go wrong will go wrong."

Posts: 2062 | From CT | Registered: Jul 2008  |  IP: Logged | Report this post to a Moderator
DaveinCt
LymeNet Contributor
Member # 5818

Icon 1 posted      Profile for DaveinCt   Author's Homepage     Send New Private Message       Edit/Delete Post   Reply With Quote 
Yes, that was ruled out during my last tests....

--------------------
Thx,
Dave (Now in VA.)

Posts: 207 | From Lynchburg, VA. | Registered: Jun 2004  |  IP: Logged | Report this post to a Moderator
Pinelady
Frequent Contributor (5K+ posts)
Member # 18524

Icon 1 posted      Profile for Pinelady     Send New Private Message       Edit/Delete Post   Reply With Quote 
I know you say no Lyme but looks like lyme. What does protein level say?

--------------------
Suspected Lyme 07 Test neg One band migrating in IgG region
unable to identify.Igenex Jan.09IFA titer 1:40 IND
IgM neg pos
31 +++ 34 IND 39 IND 41 IND 83-93 +
DX:Neuroborreliosis

Posts: 5850 | From Kentucky | Registered: Dec 2008  |  IP: Logged | Report this post to a Moderator
peacemama
LymeNet Contributor
Member # 17666

Icon 1 posted      Profile for peacemama     Send New Private Message       Edit/Delete Post   Reply With Quote 
My hemo is always super high. I am a carrier for hemochromatosis, but that shouldn't be affecting it.

My ferritan has always been low -- 10.

So, the stores suck (babesia driven, I believe) and the blood itself has too much.

I think Babs can do whatever it wants and can screw up the blood in both direction.

Just my opinion.

Posts: 564 | From Tick Hell | Registered: Oct 2008  |  IP: Logged | Report this post to a Moderator
nenet
Frequent Contributor (1K+ posts)
Member # 13174

Icon 1 posted      Profile for nenet     Send New Private Message       Edit/Delete Post   Reply With Quote 
This study discusses the uptake of ferritin in Babesia microti:

"Feeding Mechanisms in Extracellular Babesia microti and Plasmodium lophurae"

http://www3.interscience.wiley.com/journal/119646309/abstract?CRETRY=1&SRETRY=0

SYNOPSIS. Although large hemoglobin inclusions are observed in intraerythrocytic Babesia microti parasites, they are absent from parasites freed of hamster red cells by immune lysis with antihamster erythsocyte serum. Babesia microti has no cytostome.

This parasite, therefore, does not appear to feed by phagocytosis of large boluses of hemoglobin, as does Plasmodium. To determine whether Babesia can pinocytose protein, free parasites were fed ferritin in an in vitro system.

Ferritin was taken up from the entire cell surface into narrow channels within 15 min at 37 C. Only merozoites, with their pellicular complex, failed to take up the protein. By 60 min, the ferritin was highly concentrated in many channels and vesicles, which formed interconnecting stacks.

The ferritin-containing channels became associated with membrane whorls of the multimembranous structure. Membrane whorls were also observed in the process of extrusion in samples incubated for longer times. These events may represent steps in the digestion and excretion of the pinocytosed protein.

Empty channels formed when Babesia was fed albumin. The diaminobenzidine reaction for hemoprotein was positive for the channels in both free and intraerythrocytic babesias. The staining reaction was completely inhibited by cyanide, but not at all by aminotriazole. These results further suggest that Babesia pinocytoses hemoglobin in vivo.

Plasmodium lophurae parasites freed of red cells by immune lysis are surrounded by 2 membranes and apparently can ingest ferritin only through the cytostome. Extracellular cytostomal feeding involves both membranes, as it does in vivo.

Ferritin was found in food vacuoles, some of which contained hemoglobin ingested before parasite isolation, connected to or near the cytostome. In both Plasmodium and Babesia low temperature inhibited ferritin uptake."


"A merozoite ...is a daughter cell of a protozoan parasite. Merozoites are the result of asexual reproduction"

http://en.wikipedia.org/wiki/Merozoite

"Ferritin is a globular protein complex consisting of 24 protein subunits and is the primary intracellular iron-storage protein in both prokaryotes and eukaryotes, keeping iron in a soluble and non-toxic form. Ferritin that is not combined with iron is called apoferritin."

http://en.wikipedia.org/wiki/Ferritin


Just throwing out guesses here, but it seems there is one stage of the Babesia lifecycle that has a decreased ability to uptake ferritin. Perhaps between that and the destruction of red blood cells, there could be periods of heightened ferritin levels?

I am not a scientist or doctor, so this is just layman's brainstorming, here.

--------------------
Dr. C's Western Blot Explanation

Lymenet Success Stories

ILADS Treatment Guidelines

Medical & Scientific Literature on Lyme

"Long-Term Antibiotic Therapy Improves Persistent Symptoms Associated with Lyme Disease"

Posts: 1176 | From KY | Registered: Sep 2007  |  IP: Logged | Report this post to a Moderator
Lymeorsomething
Frequent Contributor (1K+ posts)
Member # 16359

Icon 1 posted      Profile for Lymeorsomething     Send New Private Message       Edit/Delete Post   Reply With Quote 
I see that hemolytic anemia can also cause iron spikes and the non-immune form can be caused by none other than Babesiosis...

--------------------
"Whatever can go wrong will go wrong."

Posts: 2062 | From CT | Registered: Jul 2008  |  IP: Logged | Report this post to a Moderator
   

Quick Reply
Message:

HTML is not enabled.
UBB Code is enabled.

Instant Graemlins
   


Post New Topic  New Poll  Post A Reply Close Topic   Feature Topic   Move Topic   Delete Topic next oldest topic   next newest topic
 - Printer-friendly view of this topic
Hop To:


Contact Us | LymeNet home page | Privacy Statement

Powered by UBB.classic™ 6.7.3


The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:

The Lyme Disease Network of New Jersey
907 Pebble Creek Court, Pennington, NJ 08534 USA


| Flash Discussion | Support Groups | On-Line Library
Legal Resources | Medical Abstracts | Newsletter | Books
Pictures | Site Search | Links | Help/Questions
About LymeNet | Contact Us

© 1993-2020 The Lyme Disease Network of New Jersey, Inc.
All Rights Reserved.
Use of the LymeNet Site is subject to Terms and Conditions.