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» LymeNet Flash » Questions and Discussion » Medical Questions » 1st day of Mepron and I'm sick as a dog. Is this a good sign ?

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Author Topic: 1st day of Mepron and I'm sick as a dog. Is this a good sign ?
lymetwister
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No problem with the first dose, but I took it at night. Took the second dose 750mg yesterday morning and I have been sick as a dog since.

Symptoms: Fatigue, Body Aches, Chills, Nausea, Lots of Diarrhea, Freezing down to the bone, plus exacerbation of previous symptoms.

I'm not crying, possibly due to adding Zoloft about 10 days ago, but I feel like death.

I will be pulsing M-W-F and wondering if I should skip tomorrow or just suck it up.

Lots of green bile in the toilet so I guess I don't need any coffee enemas :-)

Drinking tons of hot tea and lots of laying around with frequent hot baths.

I had been on the Doxy/Tindamax combo prior without any of this and have never had GI problems in the past.

Appreciate any feedback.

Gary [toilet]

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B4LYME
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Are you taking the mepron with food? I've been eating a little when I get up and waiting a little before I eat a scoop of peanut butter and eat something else. At night it's easier because dinner is easier to eat for me.

I have also found that taking ginger capsules helps a lot with the naseau. They have tea too, but I think the capsules work better.

I hope this helps some. I started this round of mepron on Monday. I'll take it for 3 weeks and then have a week off.

Hope you feel better soon.

B4Lyme

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lymetwister
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Yes, just a bowel of cerial in the morning. But did take a big scoop of peanut butter with it.

With the dinner dose, I had much more food in me, but again took it with peanut butter.

Gary

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canefan17
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i didn't get a herx from malarone/zith until about day 5 or 6
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sixgoofykids
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I didn't herx on it till day 24.

Every third day is odd. Typically you don't pulse Mepron. Glad it seems to be doing something.

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ping
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lymetwister - Sounds every bit like a Mepron herx, esp. the chills to the bone. Only Mepron did that to me when I was in tx. Yeah, it's tough.

As for skipping a dose, it wouldn't be unheard of. Your taking a teaspoon (5ml) dose, every 12 hours, right?

The first time I took Mep, it took 18 days to herx. 2nd time, it took 12 days. 3rd time, I herxed on the first dose. Brrrr! Freezing cold!

You might try 1/2 dose during the day and full dose at night until the herxes become more bearable. I'm not a doctor, so you might want to check with your doc or the nurse. I just don't see an advantage in being knocked on your butt.

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ping
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lymetwister
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I hear ya Ping, but I'm pretty much knocked on my butt to start with, just a bit more torture as with everything.

I will try and suck it up as it's just M-W-F. Taking Doxy and Tindamax on other days.

I was told, this is close to what Dr. J in D.C. does with his patients. I think he uses Flagyl instead of Tindamax, but the two drugs are close.

Appreciate your thoughts,

Gary

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seekhelp
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it's a pretty brutal drug Gary. I've taken it for 35+ days with a few very small breaks due to major toxicity. My liver numbers mildly elevate. It's caused a lot of head pressre, chills, and a very tipsy feeling. I'm not sure if the 750 mg of Zithromax caused me ototoxicity.

I had a few better days, but the bad get really bad. I'm more inclined to take Malarone moving forward. I felt better on that before w/less side effects, but it may have been due to much lower doses of Atoquovone (2 tablets only). 2 tsp Mepron = 6 tablets Malarone. Malarone has a second drug in it though.

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springshowers
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Maybe you should take less to start? Just an idea??

I happen to be one of those that Mepron helped and the more I took the better I felt. I took it for 9 months at 4 doses a day and sometimes 6 and felt better and better.

It is the only ORAL drug that I have not felt like hell on.. WHo knows why? RIght?

THis whole disease and its treatments are a mystery and we are all so different.

Hope you find a balance and feel better.

Did you start the other drugs separately. And one by one to make sure you know what is doing what??

Good Luck to you..

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lymetwister
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The Tindamax and Doxy were causing Herx's, but tolerable.

When I added the Mepron, I took it with the Zithromax, but I can only assume the Mepron is the culprit.

I know I have alot of Babs to kill off. Perhaps I'm making a chip at it.

It's that kind of cold you get that only a hot bath will fix temporarily.

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sixgoofykids
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You can't make that assumption. I did fine on Mepron/Biaxin, but even towards the end of treatment when my bug load should have been lower, I NEVER could tolerate the zith, even if pulsed. I'd go from feeling pretty good and being pretty functional to being bedridden.

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ping
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Gary, I think it's the extreme chills that's the dead giveaway, pointing to the Mepron (& Babs die-off). Most all the literature I've read, esp. from Dr. K. states extreme chills (& I mean extreme) as a classic sx of Babs die-off.

Yes, the warm (or downright hot) bath helps. I just got under about 3 blankets (1 of them electric), fully clothed, with socks on and a scarf on my head and still shivered. When it started to wear off, I was hotter than all get-out and sweating! LOL!

Best to you in your Bab-slaying.

--------------------
ping
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lymetwister
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Ping, if your correct than for once I'm killing something, finally !

Just got out of the tub for the 3rd time today.

I used my Sauna earlier and that me Herx more. I won't use that anymore until I get my load down.

Gary

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Larkspur
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I just finished 6 weeks of Mepron/Flagyl -uggh!Also did Olive leaf extract with it for 30 days.

I had Horrible herxing. I felt I didn't have a choice to go through it b/c I was feeling so terrible before I started but I spent pretty much the first 4 weeks at home with the blinds drawn, and the last 2 weeks the same but with the blinds up!

I had never done flagyl before - not fun!

--------------------
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the life we've planned, so as to have the life that is waiting for us" - e.m. forster

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been
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Today is day 6 for me on Mepron.

No herx yet not sure if this is a good thing or a bad thing?

Although I'm always cold, but no extreme chills.

My right cervical lymph node was swollen the second day but it's back to normal for most part.

I feel a little less foggy today too!

I think something good is happening. I'm trying to stay positive [Smile]

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seekhelp
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I remember there was a post on Lymenet Europe from a user who stated too many here often mistake the Mepron herx for the drug's side effects. I'm not a fan of that site, but I tend to agree. It's a brutal drug. I know it helps some bigtime, but it's a fine line.
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springshowers
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Mepron has a lot of side affects to be aware of.. Yes.

Ironically this drug is the only ORAL Drug that Helped me with no herx. Werid

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ping
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Here you go, twister. Click around on this website for a bit and you'll find info re: Babs herx.

www.klinghardtacademy.com

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ping
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Sammi
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Gary, are you taking Zithromax with the Mepron?
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lymetwister
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Yes, taking them together.

Gary

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Sammi
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Okay, good.

I have had some doozy herxes from Babesiosis. It should get better over time. Hang in there okay?

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Skyler
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That is what always happened to me when I took Mepron. I never could last more than 4 or 5 days on it before i would just feel way too sick adn my weight would get so low that I would have to go off of it.

Hang in there! I hope this med works for you.

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I'm probably sleeping...

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