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» LymeNet Flash » Questions and Discussion » Medical Questions » Anyone quit smoking and get symptoms back?

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Author Topic: Anyone quit smoking and get symptoms back?
Mrs.Lyme
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Can't believe how awful I feel since quit smoking 2 weeks ago.Dizzy almost all the time,migrating joint pains,tingling in hands and feet,chills on and off,lousy balance.Have been off ABX since early Sept. and doing fine until this hit me like a ton of bricks.Can't imagine quitting smoking would cause relapse but I feel as bad, if not worse,than when I was bitten in May.
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TerryK
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Yes. I descended into illness and disability when I stopped smoking. My health slowly declined for about a year at which point I was very sick. Both my mother and sister have had the same experience when they stopped smoking. I think there are some posts about others who have experienced the same thing here in the archives.

I don't know for sure what causes it but I know that borrelia affects acetylcholine in a negative way. Smoking keeps it at the synapse. I use acetylcholine to control some of my symptoms. It is circumstantial but I do believe there is a relationship. It could be oher things as well.

Terry
I'm not a doctor

Posts: 6285 | From Oregon | Registered: Jan 2006  |  IP: Logged | Report this post to a Moderator
Marnie
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http://jmm.sgmjournals.org/cgi/reprint/49/7/675.pdf

Scroll down to almost the end.

This has been mentioned before.

"Similarly to lp28-1, borrelia cells can spontaneously loose lp25.

This plasmid is essential for survival in both tick and mammalian hosts,

however; lp25 is not required
for in vitro growth (Purser and Norris, 2000).

The plasmid harbors bbe22, the gene that
encodes a nicotinamidase.

Nicotinamidase is absolutely essential in that

***it provides the critical step in converting nicotinamide to nicotinic acid***

in the exogenous pathway to synthesizing NAD as an energy source (Purser et al., 2003)."

http://etd.lsu.edu/docs/available/etd-09052007-124840/unrestricted/DeRouen_Polito_thesis.pdf

"Mol Microbiol. 2003 May;48(3):753-64.

A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host."

PMID: 12694619

Both NAD+ and NADH absorb strongly in the ultraviolet due to the adenine base.

UV light exposure to mice with lyme makes lyme worse.

I thought because UV light (UVA and UVB, not UVC which is destroyed by our protective ozone layer) triggers inflammation to "pave the way"
-> MMPs, but perhaps it is due to the increased NAD and NADH.

Not, notice, NADP.

Bb inhibits phosphate transfers. That is what a PKC inhibitor does.

Among its uses...NAD can:

"acting as a substrate for bacterial DNA ligases and a group of enzymes called

***sirtuins that use NAD+ to remove acetyl groups from proteins.***"

Acetyl loss...acetyl gain:

http://www.neurologyreviews.com/ADs/Axona_newsletter.pdf

Start with what is Axona (hint Caprylic acid)

BTW...NAD can come from Tryptophan too. The same enzyme is used to convert it to serotonin and then melatonin and the other pathway leading to toxic quin acid, but eventually to NAD.

http://www.la-press.com/effects-of-kynurenine-pathway-metabolites-on-intracellular-nad-synthes-a1389

Lots more of really interesting info. here:

http://www.vitamin-basics.com/index.php?id=49

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Truthfinder
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Apparently, you are not alone, Mrs. Lyme. There was a whole discussion about this over in the General forum a few months back.... I had to do a search to find it:

http://flash.lymenet.org/scripts/ultimatebb.cgi/topic/3/22832?

--------------------
Tracy
.... Prayers for the Lyme Community - every day at 6 p.m. Pacific Time and 9 p.m. Eastern Time � just take a few moments to say a prayer wherever you are�.

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Mrs.Lyme
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Thanks for all feedback.Guess I was not "cured" as I thought.Will get back on ABX ASAP,take supplements to increase acetylcholine,and,if all else fails,get some nicotine gum (although I only quit ciggies for monetary reasons and that gum is NO BARGAIN !!!!!)
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Snailhead
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From one ex smoker to another, congratulations. Hardest thing I have EVER done. I too, had all my symptoms come crashing in on me three months after I quit. That was about five years ago.

I still chew the nicotine gum, and stubbornly refuse to give it up. Don't know if you have seen it, but there is something called the "electronic cigarette", which gives you a puff of nicotine (only) and it vaporizes into a water type thing. No smoke.

If it had been around five years ago when I quit, I would have used it! God bless you.

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Mrs.Lyme
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Snailhead,did the gum help relieve the symptoms?I don't think I can take this CONSTANT dizziness much longer. I'm afraid to drive.The joints,tingling,chills,etc. are tolerable but this head stuff is AWFUL.I've had it before but never this bad.If the nicotine in another form won't relieve this,I'll save my money.Those e-cigs do look interesting, but I don't think they're available in stores yet,only online.
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Snailhead
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Hi, I cannot really say if the gum helped the symptoms, because I have been chewing the gum since I quit, and it was AFTER I quit (about three months) that all heck broke loose.

So I do not know how my body would have reacted w/o the gum. Would I have been worse? Don't know.

I guess your only option with that would be chew it and see if you get to feeling a little better.

Keep up the great work; I know how hard it is.

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Snailhead
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P.S. remember there are 4,000 chemicals in cigarettes. Your body is not happy right now, being "deprived" of all the crud it was used to.

My whole first month was nasty. I used Xanax and chugged water when the urge was the worst. Helped.

Posts: 374 | From United States | Registered: Nov 2008  |  IP: Logged | Report this post to a Moderator
   

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