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» LymeNet Flash » Questions and Discussion » Medical Questions » Spirochete Research may point to new Treatment

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Author Topic: Spirochete Research may point to new Treatment
Pinelady
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http://www.umass.edu/loop/talkingpoints/articles/99534.php

What the Brorsons' work shows is that, unlike other antibiotics, Tygecycline administered at the correct dosage and timing destroys the

bacterium even when it has protected itself in this quiescent stage. Other antibiotics, if they do anything at all, simply cause B. burgdorferi

to enter its RB propagule state and wait out the treatment. ``Tigecycline is, so far, the only known antibiotic that destroys the Lyme disease

spirochete in both the growing and the quiescent RB stages of its life history'' Margulis notes.

Boy I hope its true.

--------------------
Suspected Lyme 07 Test neg One band migrating in IgG region
unable to identify.Igenex Jan.09IFA titer 1:40 IND
IgM neg pos
31 +++ 34 IND 39 IND 41 IND 83-93 +
DX:Neuroborreliosis

Posts: 5850 | From Kentucky | Registered: Dec 2008  |  IP: Logged | Report this post to a Moderator
sickpuppy
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thank you so much for posting this!!!!
Posts: 702 | From North Eastern USA | Registered: Dec 2009  |  IP: Logged | Report this post to a Moderator
Pinelady
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http://www.wyeth.com/hcp/tygacil

--------------------
Suspected Lyme 07 Test neg One band migrating in IgG region
unable to identify.Igenex Jan.09IFA titer 1:40 IND
IgM neg pos
31 +++ 34 IND 39 IND 41 IND 83-93 +
DX:Neuroborreliosis

Posts: 5850 | From Kentucky | Registered: Dec 2008  |  IP: Logged | Report this post to a Moderator
sammy
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Great article! Thank you Pineladay [Smile]
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Pinelady
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Incidentally Pfizer bought out Wyeth.

Also Pfizer just received the highest in history fine for falsifying data.

I would think if it is true this is why Pfizer made the Wyeth deal. They saw dollars in it.

But who knows. I would still sign up for trial....LOL

They did mention timing-so I bet it too has to be pulsed.

--------------------
Suspected Lyme 07 Test neg One band migrating in IgG region
unable to identify.Igenex Jan.09IFA titer 1:40 IND
IgM neg pos
31 +++ 34 IND 39 IND 41 IND 83-93 +
DX:Neuroborreliosis

Posts: 5850 | From Kentucky | Registered: Dec 2008  |  IP: Logged | Report this post to a Moderator
Pinelady
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http://kroun.ulmarweb.dk/York2003/Brorson.htm

BRORSONs works on cystic forms of Borrelia burgdorferi

--------------------
Suspected Lyme 07 Test neg One band migrating in IgG region
unable to identify.Igenex Jan.09IFA titer 1:40 IND
IgM neg pos
31 +++ 34 IND 39 IND 41 IND 83-93 +
DX:Neuroborreliosis

Posts: 5850 | From Kentucky | Registered: Dec 2008  |  IP: Logged | Report this post to a Moderator
Pinelady
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http://www.ncbi.nlm.nih.gov/pubmed/19843691

Destruction of spirochete Borrelia burgdorferi round-body propagules (RBs) by the antibiotic tigecycline.

--------------------
Suspected Lyme 07 Test neg One band migrating in IgG region
unable to identify.Igenex Jan.09IFA titer 1:40 IND
IgM neg pos
31 +++ 34 IND 39 IND 41 IND 83-93 +
DX:Neuroborreliosis

Posts: 5850 | From Kentucky | Registered: Dec 2008  |  IP: Logged | Report this post to a Moderator
Pinelady
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http://lymerick.net/1998-Brorson-cyst.htm

Brorson's observation in this paper, that it takes old cysts 4 weeks to convert to as many as 5 mobile spirochetes per cyst, may thus explain the clinically observed 4- week CYCLICITY in Lyme borreliosis (LB) - as well as the observed RELATIVE RESISTANCE to beta-laktam antibiotics, and SERONEGATIVITY !! - and it also explains the clinical observation, that in early LB of only 1-3 weeks duration (only young cysts), shorter antibiotic courses of 10-14 days duration may just about be effective in preventing relapses, while antibiotic treatment of late LB (old cysts) teoretically must be of at least 4 weeks duration, because one must treat long enough for all the oldest cysts to convert back to spirochetes and build their cell walls and thus be susceptible to a beta-laktam-antibiotic!!

/Marie Kroun

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=99160086&dopt=Abstract
99160086 APMIS 1998 Dec;106(12):1131-41

A rapid method for generating cystic forms of Borrelia burgdorferi, and their reversal to mobile spirochetes.
Brorson O, Brorson SH "Excerpt from discussion section:

The cysts observed in our study seem to resemble the spheroplast-L-forms observed by other researchers (11, 35), which seem to have defects

in their cell wall manifested by resistance towards beta-lactam antibiotics (16). Since the conversion from normal mobile spirochetes to

cystic forms occurred very rapidly, complete absence of cell wall as in L-forms is dubious, but the similarity with L-forms is shown by the

inability to retain their original shape.
The biological activity of the cystic forms was confirmed by the step by step development to

normal mobile spirochetes in BSK-H medium, and also indicated by the presence of RNA in 5-week-old cysts due to red-orange staining with

acridine orange (pH 6.4) (Fig. 4b). This seems to be a new observation in the development of B. burgdorferi (20). Bruck et al. (35) also illustrated biological activity by incorporation

or S-methionine in the cysts (spheroplast). The creation of as many as five spirochetes from each cyst may explain why the generation time was

shorter for production of mobile spirochetes from cysts compared to that for normal mobile spirochetes cultivated conventionally. The

generation of the normal mobile spirochetes which were converted from cysts was somewhat variable in the sense that they sometimes seemed to need a

long stationary period before exponential growth occurred. Whether cysts are converted to normal mobile spirochetes or not depends strongly on the

growth medium used, and possibly also the generation time.
It seems as though normal mobile spirochetes are developed from the dense core structures or the

cyst by being ""fed"" with core substances as the ""infant-spirochete"" protrudes from the cyst. The development of vegetative bacteria from dense

L-forms has been suggested as a method for Enterococcus faecalis to convert from L-forms to vegetative forms (40). The observation by TEM

that blebs transformed into thin filaments leads us to speculate that these filaments develop to normal mobile spirochetes. If so, the blebs have

to contain enough genetic material to synthesize a new bacterium (22).
Old cystic forms of B. burgdorferi require

prolonged cultivation to convert to normal mobile spirochetes (4 weeks as opposed to 9 days for young cysts). Similar cystic forms may occur in

the human organism (11, 14, 15), and they may explain the long periods or latency, resistance to antibiotics, negative serological results

(3-7, 10, 12, 13, 25), and low PCR sensitivity (5, 8, 10). For these reasons it is important to examine the antigens of the envelope of the

cysts. DNA sequences for PCR analysis, and the cysts sensitivity to antibiotics and other chemicals. It may be hypothesized that antigenic

variation in B. burgdorferi (19, 41) occurs inside the cyst while the microbe is protected against external stress, and therefore antigens

detected on the cyst envelope in vitro differ from the ones present in vivo. In conclusion, we believe that the present method for rapid and

easy generation of stable cysts will be a useful tool in further research on B. burgdorferi."

--------------------
Suspected Lyme 07 Test neg One band migrating in IgG region
unable to identify.Igenex Jan.09IFA titer 1:40 IND
IgM neg pos
31 +++ 34 IND 39 IND 41 IND 83-93 +
DX:Neuroborreliosis

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Pinelady
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Haven't done efficacy studies in under 18 years of age. http://www.wyeth.com/hcp/tygacil/dosing/administration

--------------------
Suspected Lyme 07 Test neg One band migrating in IgG region
unable to identify.Igenex Jan.09IFA titer 1:40 IND
IgM neg pos
31 +++ 34 IND 39 IND 41 IND 83-93 +
DX:Neuroborreliosis

Posts: 5850 | From Kentucky | Registered: Dec 2008  |  IP: Logged | Report this post to a Moderator
billclo
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This is pretty neat. My current Lyme doc, when I previously showed him an article by the same researchers concerning Tindamax, said that not only was he familiar with their work, but that he knew them. [Smile]

The Tindamax seemed to have helped me by the way.

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MariaA
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I found this set of musings by LymdMD interesting- and I also have had a very positive experience with Tindamax:
http://lymemd.blogspot.com/2009/11/cystic-forms-and-relapse.html

--------------------
Symptom Free!!! Thank you all!!!!

Find me at Lymefriends, I post under the same name.
diet: http://lymefriends.ning.com/group/healthylowcarbrecipes
Homemade Probiotics thread
Herbal Links Thread

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Marnie
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When this comes to the marketplace:

http://www.faqs.org/patents/app/20080249092

When you click on the above, use your edit key and find "autoimmune".

If Bb is inhibiting PKCB2 and the receptor CB2 comes to the cell surface...

It maybe a call for help (agonist).

Ideally our own antibody to Bb (mAB CB2) would not be damaged and IT would be the helper.

http://iai.asm.org/cgi/reprint/65/5/1908.pdf


CB2 is ONE of the cannaboid receptors.

Cannaboids REDUCE inflammation.

What happens if PKCB2 is INHIBITED?

This:

http://diabetes.diabetesjournals.org/content/52/6/1519.abstract

Start where it says: "inhibition of PKCB2 activation..."

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Dawn in VA
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Interesting info indeed.

--------------------
(The ole disclaimer: I'm not a doctor.)

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jl123
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I am confused why aren't more lyme patients not at least a little exited by this discovery?

It seems that Tygecycline might be different than other anti-bacterials in that the lyme bugs can't run away/drill away or shape-shift like they can with most other medicines? No?

So if this drug kills each bug on contact no matter the bugs "reaction" then its doing more than other drugs know to this point?

Does anyone have any idea when this drug might start human lyme trials? thanks, J

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KS
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This is very interesting...
Posts: 561 | From mass | Registered: Jul 2007  |  IP: Logged | Report this post to a Moderator
treepatrol
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up

--------------------
Do unto others as you would have them do unto you.
Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.

Newbie Links

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Marnie
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Must REACH the pathogen first.

This MIGHT be at play:

"Impaired microvascular circulation hinders white cell migration into the area of infection and limits the ability of antibiotics to reach the site of infection in an effective concentration."

Which makes it harder, not impossible, but harder.

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Pinelady
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JL I think with the excitement comes fear.

There have been a few antibiotics introduced to the

market and quickly withdrawn due to incidence of

adverse effects in some individuals.

Horrible I might add, most noted in patients who have socalled autoimmunity/ongoing infections of virus' and bacterias'.

So to say this will be acceptable in Lyme patients remains to be seen- but could be!

--------------------
Suspected Lyme 07 Test neg One band migrating in IgG region
unable to identify.Igenex Jan.09IFA titer 1:40 IND
IgM neg pos
31 +++ 34 IND 39 IND 41 IND 83-93 +
DX:Neuroborreliosis

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David Miller
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This isn't for casual or early stage use as there's no oral form available.

It's IV only for now. I wonder if it'll stay that way. Did anyone catch how well it penetrates? Vancomycin is only used for certain gastric infections because it won't cross the intestinal barrier. Hopefully tigecycline isn't so restricted and can be taken orally before too long.

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Beachinit
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Speaking of IV tetracycline derivatives (tigecycline) in place of orals, how does that compare to say IV azithromycin in place of oral macrolides. Both target tissue and also get the blood levels higher when given IV. Dr. B's handout seemed to speak well of IV zithro. Have the Brorsons already tested zithro? I have heard zithro is cheaper (for drug not including administration etc) IV than tablet form.

Beachinit

--------------------
Ideas not advice.

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