Thanks TC! This one is a very interesting case study. I like the nice long list of co=authors. You can see where they work if you click on Author Information. And the total text is free! Might be a good one to show doubting doctors.
" In summary, we provide several lines of evidence that suggest that B. burgdorferi can persist in the human body,
not only in the spirochetal but also in the antibiotic-resistant biofilm form, even after long-term antibiotic treatment.
The presence of infiltrating lymphocytes in the vicinity of B. burgdorferi biofilms suggests that the organism in biofilm form might trigger chronic inflammation."
-------------------- Ann-OH Posts: 982 | From Ohio | Registered: Aug 2014
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TX Lyme Mom
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quote:Originally posted by MADDOG: Very good. And the last but not least thing Lyme does is turn into a virus to avoid ABX,then turn back into a bacteria when the coast is clear. MADDOG
I used to wonder if bacteria could turn into viruses, but I've never seen anything in the medical literature suggesting this possibility. Do you have any reliable reference to confirm this statement?
Please understand that I'm not trying to contradict you nor to put you on the spot. My motive for asking is for my own personal knowledge. I do not have a strong background in biology. (I used to be an elementary school teacher with an "advanced sixth grade background in Simple Science.")
If anyone else can answer this basic question, please help us out.
Posts: 4561 | From TX | Registered: Sep 2002
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Thank you so much for posting this Tincup. I know you know the back story to this case.
Thank you to Dr Eva Sapr, Dr L, and others π The patient's name was Vicki Logan. Her case has been widely publicized. She was Dr L 's patient. He never gave up on her and wrote a book about this amazing Lyme warrior; Vicki Logan continues to this day in helping other Lyme sufferers.
"The Long-Term Persistence of Borrelia burgdoferi Antigens and DNA in the Tissues of a Patient with Lyme Disease"
Abstract; Whether Borrelia burgdoferi can persist for long periods of time in the human body even after a long clinical course and after long-term antibiotic treatment.
Human autopsy tissues were obtained and investigated from a 53 year old female from Weatchester County, NY State. This Lyme patient recieved extensive antibiotic treatments over the course of her 16 year-long illness. Autopsy tissue sections of the brain, heart, kidneys, and liver were analyzed. Significant pathogicalchanges including Borrelial spirochetes clusters were found in all the organs. The cluster aggregates were contained in a well-established biofilm.
Analyses show significant numbers of infiltrating inflammatory CD3 and T lymphocytes cells present next to the B burgdoferi biofilms.
In summary,we provide several lines of evidence that suggest the B burgdoferi can persist in the human body, not only in the spirochetal but also in the antibiotic-resistant biofilm form even after long-term antibiotic treatment.
The presence of CD3 T lymphocytes in the vicinity of the B burgdoferi biofilms suggest that the organism in the biofilms might trigger chronic inflammation.
Clnical History; 39 year old woman is evaluated by one of the authors, Dr L in 1989 2 year history of spastic paraparesis, cranial nerve palsied and abnormal large number of lymphocytes in CSF. Patient lived in highly epidemic area of Lyme, Westchester County, NY. No history of tick attachment or EM rash Testing of Lyme disease was entirely negative Splenectomy was performed in 1976 Patient was a well-functioning and highly valued pediatric intensive care nurse prior to falling ill She did not have any pets
Patient was treated for 21 day I.V. Cefotaxime in April 1990 Minocyccline for 4 months A 'pulse' regimen of Cefotaxime in Jan 1992 weekly fior 13 weeks and intensified for 10 more months IV antibiotic treatment was discontinued, she deteriated and transferred to Mayo Clinic in MN In Jan 1993, she was given 10 day IV cefriaxone followed by oral prednisone steroid for 6 weeks In May 1993 she deteriorated Treatment with 109 continuous days of IV resulted in dramatic improvement and enabled her to walk Daily IV cefotaxime was continued for an additional 3 months In the ensuing months off treatment, she once again deteriated
Changes in the patient's insurer's policies for reimbursement prevented further antibiotic treatment and she deteriorated She often failed to satisfy CDC criteria for 5 out of 10 CDC specific IGG bands
Patient filed lawsuit againest her insurers for declining treatment throughout her illness, lost, appealed, lost; (The suit was ultimately settled out of court, the terms of which were sealed. Whatever the settlement was, it did not include any acknowledgement of Vicki's right to be reimbursed for costs of treatments.)
Donated IV Ceftriaxone (3x week) provided by the manufacturer in 2000 and March 2001, with some hiatuses showed no benefit
Following another change in her insurance to public health benefits, IV cefotaxime was applied for 3 weeks in May 2003 but was suspended because of lack od reimbursement
While attempts to secure means of reimbursement were underway, on July 6, 2003, patient suffered from seizure disorder Patient was transported by ambulance to local hospital After discussion with hospital physicians and next of kin, a DNR order was issued Shortly after patient died
Pathological findings of brain, CNS, PNS, heart, kidneys and lungs showed biofilms of B burgdorferi spirochetal clusters surrounded by CD3 and T lymphocytes which caused local tissue inflammation.
Frontal cortex and subcortical white matter were most severely affected in brain Spinal cord cord shows servers degeneration The heart sections of left and right ventricles showed fibrous scars The liver showed marked lymphocytes cell inflammation The kidneys had large biofilms of B burgdoferi spirochetal clusters
All organs had evidence of B burgdoferi spirochetal clusters and aggregates ( multi biofilm bateria micro-organisms in a colony).
Biofilms are responsible for long-term persistence. Biofilms protect bacteria from antibacterial therapy. Biofilms are surrounded by CD3 lymphocytes, which cause inflammation.
Our recent studies demonstrated that only certain antimicrobials and a combination of antibiotics are able to reduce the size of borrelia biofilms (stevia, bee venom, and melliltin.)
Posts: 2151 | From Florida | Registered: Nov 2016
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- Bonnie, Your post is so very helpful, and it really wakes me up in many ways I cannot even voice right now . . . (and thanks so much for breaking up the text into readable portions, that's such a help!) . . . -
Posts: 48021 | From Tree House | Registered: Jul 2007
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