posted
Never heard of it. All new drugs welcomed, got to get the keets in a state of constant surprise.
Posts: 8430 | From Not available | Registered: Oct 2000
| IP: Logged |
What is Tigecycline injection? What should my health care professional know before I receive Tigecycline? How should this medicine be used? What if I miss a dose? What drug(s) may interact with Tigecycline? What side effects may I notice from receiving Tigecycline? What should I watch for while taking Tigecycline? Where can I keep my medicine?
What is Tigecycline injection? (Back to top) TIGECYCLINE (Tygacil�) is an antibiotic. Tigecycline stops the growth of certain bacteria that cause certain infections. Tigecycline is used to treat infections of the skin and the abdomen. Generic tigecycline injections are not available.
What should my health care professional know before I receive Tigecycline? (Back to top) They need to know if you have any of these conditions: *intestinal disease *liver disease *other chronic illness *an unusual reaction to tigecycline, tetracycline antibiotics, other medicines, foods, dyes, or preservatives *pregnant or trying to get pregnant *breast-feeding
How should this medicine be used? (Back to top) Tigecycline injection solution is for infusion into a vein. Tigecycline is usually first given in a hospital or clinic for severe infections. If you are to give yourself tigecycline by infusion at home, follow the directions on the prescription label. Finish the full course prescribed by your prescriber or health care professional even if you think your condition is better. Do not stop using except on your prescriber's advice. Make sure you understand how to store and give yourself tigecycline. Ask your prescriber or health care professional if you have any questions.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
What if I miss a dose? (Back to top) If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.
What drug(s) may interact with Tigecycline? (Back to top) *female hormones, including contraceptive or birth control pills *warfarin
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What side effects may I notice from receiving Tigecycline? (Back to top) Side effects that you should report to your prescriber or health care professional as soon as possible: *difficulty breathing *fever *increased sensitivity to the sun or ultraviolet light *irregular heart beat *redness, blistering, peeling or loosening of the skin, including inside the mouth *severe or watery diarrhea *skin rash, itching *unusual weakness or tiredness *severe nausea or vomiting *swelling of the hands or feet *yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome): *back pain *change in taste *chills *constipation *difficulty sleeping *dizziness *drowsiness *dry mouth *flushing *headache *loss of appetite *mild diarrhea *nausea *sweating *upset stomach
What should I watch for while taking Tigecycline? (Back to top) Tell your prescriber or health care professional if your symptoms do not begin to improve in a few days.
If you get severe or watery diarrhea, do not treat yourself. Call your prescriber or health care professional for advice.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you.
Notify your health care professional if you are scheduled to have any surgery, procedure, or medical testing (including myelography); tell your prescriber or health care professional that you have been taking tigecycline.
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
TYGACIL is indicated for the treatment of adults with:
Complicated skin and skin structure infections caused by E. coli, E. faecalis (vancomycin-susceptible isolates only), S. aureus (methicillin-susceptible and -resistant isolates), S. agalactiae, S. anginosus grp. (includes S. anginosus, S. intermedius, and S. constellatus), S. pyogenes, and B. fragilis.
Complicated intra-abdominal infections caused by C. freundii, E. cloacae, E. coli, K. oxytoca, K. pneumoniae, E. faecalis (vancomycin-susceptible isolates only), S. aureus (methicillin-susceptible isolates only), S. anginosus grp. (includes S. anginosus, S. intermedius, and S. constellatus), B. fragilis, B. thetaiotaomicron, B. uniformis, B. vulgatus, C. perfringens, and P. micros.
Important Safety Information
To reduce the development of drug-resistant bacteria and maintain the effectiveness of TYGACIL and other antibacterial drugs, TYGACIL should be used only to treat infections proven or strongly suspected to be caused by susceptible bacteria.
TYGACIL is contraindicated in patients with known hypersensitivity to tigecycline.
TYGACIL should be administered with caution in patients with known hypersensitivity to tetracycline class antibiotics.
Glycylcycline class antibiotics are structurally similar to tetracycline class antibiotics and may have similar adverse effects. Such effects may include: photosensitivity, pseudotumor cerebri, pancreatitis, and anti-anabolic action (which has led to increased BUN, azotemia, acidosis, and hypophosphatemia).
In clinical trials, the most common treatment-emergent adverse events in patients treated with TYGACIL were nausea (29.5%) and vomiting (19.7%).
TYGACIL may cause fetal harm when administered to a pregnant woman.
The safety and effectiveness of TYGACIL in patients below age 18 and lactating women have not been established.
Pseudomembranous colitis has been reported with nearly all antibacterial agents and may range in severity from mild to life threatening.
Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective.
The use of TYGACIL during tooth development may cause permanent discoloration of the teeth. TYGACIL should not be used during tooth development unless other drugs are not likely to be effective or are contraindicated.
Prothrombin time or other suitable anticoagulant test should be monitored if TYGACIL is administered with warfarin.
Monotherapy should be used with caution in patients with clinically apparent intestinal perforation.
In patients with severe hepatic impairment (Child Pugh C), the initial dose of TYGACIL should be 100 mg followed by 25 mg every 12 hours. Patients should be treated with caution and monitored for treatment response.
The following drugs should not be administered simultaneously through the same Y-site as TYGACIL: amphotericin B, chlorpromazine, methylprednisolone, and voriconazole.
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
posted
The treatment for the most severe Bartonella infections is usually an aminoglycoside (IM) + a tetracycline. Though there are no studies relating the potential effect (or lack of effect) on bartonella -- as of late 2005 anyhow -- there was a review which suggested it may have potential usefulness in brucellosis, a disease caused by a related bacteria.
I think I also remember reading that Bartonella could be killed in vitro with concentrations of Doxycycline much higher than those achievable in us. However some studies said only Rifampin or Aminoglycosides could kill it in vitro. Quinolines were also suggested but I don't remember a lot of proof one way or the other (in 2005). If tigecycline was a few-fold better than Doxy perhaps it would be useful?
-------------------- "...reading the Meditations for long periods can be conducive of melancholy." --qtd. in intro to Meditations Posts: 122 | From San Diego, CA, California, United States | Registered: Mar 2005
| IP: Logged |
The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:
The
Lyme Disease Network of New Jersey 907 Pebble Creek Court,
Pennington,
NJ08534USA http://www.lymenet.org/
UBBFriend: Email this page to someone!
Printer-friendly view of this topic