(I wrapped that link...highlight, cut and paste the entire link into your search engine.)
Why was it tried?
Perhaps...Int Microbiol. 2001 Dec;4(4):209-15.
Susceptibility of motile and cystic forms of Borrelia burgdorferi to ranitidine bismuth citrate.
Brorson O, Brorson SH.
Department of Microbiology, Vestfold Sentralsykehus, Tonsberg, Norway.
Gastrointestinal symptoms accompanying Lyme disease have not been considered in the treatment of Lyme patients yet. Here we examine the effect of ranitidine bismuth citrate (RBC) on motile and cystic forms of Borrelia burgdorferi in vitro, to determine whether it could cure this bacterial infection in the gastrointestinal tract.
When motile forms of B. burgdorferi were exposed to RBC for 1 week at 37 degrees C, the minimal bactericidal concentration (MBC) was > 64 mg/ml.
At 30 degrees C, the MBC was > 256 mg/ml. When the incubation lasted for 2 weeks at 37 degrees C, the MBC dropped to > 2 mg/ml.
Bismuth aggregates were present on the surface of B. burgdorferi when RBC > or = MBC, as shown by transmission electron microscopy (TEM). Cystic forms of B. burgdorferi, exposed to RBC for 2 weeks at 37 degrees C, were examined by cultivation in BSK-H medium (Sigma B3528).
They were stained with acridine orange (pH 6.4, pH 7.4) and studied by TEM. The MBC for RBC for young cystic forms (1 day old) and old cysts (8 months old) was estimated to be > 0.125 mg/ml and > 2 mg/ml, respectively.
Bismuth aggregates were attached to the cysts and, in some, the pin-shaped aggregates penetrated the cyst wall. The bismuth aggregates also bound strongly to blebs and granules of B. burgdorferi when RBC > or = MBC.
When B. burgdorferi is responsible for gastrointestinal symptoms, bismuth compounds may be candidates for eradication of the bacterium from the gastrointestinal tract.
PMID: 12051564
Bismuth is the most "diamagnetic" of all metals, and the thermal conductivity is lower than any metal, except mercury.
Oxyhemoglobin (HbO2) is diamagnetic while deoxyhemoglobin (deoxy-Hb) is paramagnetic.
The magnetic susceptibility difference between deoxy-Hb and surrounding tissue water creates local field gradients that cause phase dispersion of nearby water protons resulting in a loss of MR signal intensity.
Since blood coursing through the activated brain region has a higher content of diamagnetic oxyhemoglobin and a lower ratio of paramagnetic deoxyhemoglobin, which normally lowers signal intensity of blood, there is a relative increase in the MR signal intensity observed in the region of activation.
Bismuth metal is used as a thermocouple material and has highest negativy known.
Bi-citrate is used in hair coloring dyes to improve color and to deodorize the stabilizing additives.
Bismuth oxychloride (BiOCl) pigments are best known for their exceptional pearlescent, nacreous effect in cosmetics (lipstick, nail polish, eye-shadow, and facial powders) where it also improves the spreadability of the cosmetics, giving them a "silkier" feel.
Its brilliance and luster surpasses that of guanin (derived from fish scales), the more expensive natural product it replaces. The pearlescence of shirt buttons is another application.
Years ago, I wrote to the Bismuth Institute in Belgium. I asked them about the various forms of bismuth and was told only 2 forms are used for people...bismuth citrate and bismuth salicylate. At that time, they were unaware of the PMID lyme abstract.
HISTORY
Pepto-Bismol was invented in 1901 by a doctor in New York, as a response to
cholera infantum,
an illness which caused severe diarrhea and vomiting. The forumula, which he originally called Mixture Cholera Infantum, consisted of pepsin, bismuth salicylate, zinc salts, salol and oil of wintergreen, and a colorant to make it pink.
Unfortunately for him, instead of selling it and making the money to capitalize on it himself, he took his formula to what was then the Norwich Pharmacal Company in Norwich, New York.
Somewhere along the line they seem to have forgotten his name, and the rest of the history proceeds without him.
They sold his formula as "Bismosal: Mixture Cholera Infantum". They renamed it to Pepto-Bismol in 1919 in order to sell it to adults. Procter & Gamble Company got their hands on Norwich Eaton Pharmaceuticals in 1982, and Pepto-Bismol along with it.
INGREDIENT BREAKDOWN
Each tablespoon (15ml) of Pepto-Bismol contains 262mg bismuth subsalicylate.
Each tablespoonful contains a total of 130mg non-aspirin salicylate. Pepto-Bismol liquid contains no sugar and is low in sodium (less than 5mg/tablespoonful).
Inactive ingredients: benzoic acid, D&C Red No. 22, D&C Red No. 28, flavor, magnesium aluminum silicate, methylcellulose, saccharin sodium, salicylic acid, sodium salicylate, sorbic acid and water.
The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:
The
Lyme Disease Network of New Jersey 907 Pebble Creek Court,
Pennington,
NJ08534USA http://www.lymenet.org/
UBBFriend: Email this page to someone!
Printer-friendly view of this topic