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» LymeNet Flash » Questions and Discussion » Medical Questions » Sodium Chloride Inhibits both Bb-growth, and Inhibits Binding of Immune Complexes

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Author Topic: Sodium Chloride Inhibits both Bb-growth, and Inhibits Binding of Immune Complexes
pq
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FWIW, some evidential blurbs on the in vitro effects of sodium chloride(NaCl) on borrelia.
Items nos. 2 and 3, are in vitro evidence that, by extrapolation to humans, may be supportive of the SALT&C regimen.

Findings below:
a. sodium chloride(NaCl) inhibits binding of circulating immune complexes...
b. NaCl significantly inhibited growth, both of infectious, and non-infectious strains of borrelia...

1. ``...we found that motility of B. burgdorferi required an environment similar to interstitial fluid[extracellular] (e.g., pH 7.6 and 0.15 M NaCl).'' PMID: 9440510

2. ``...a high salt concentration, 1.2M NaCl, which inhibits binding of circulating immune complexes...''
Schutzer,, patent # 5,187,065, February 16, 1993.
See under patent section entitled, ``Cl[q] Immune Complex Detection ``.
U.S.A. patent database.

Note: Assuming a typo, I substituted the bracketed letter `q' for the letter `g' in the term, C1[q] as it occurred in the patent, since I believe that the term `C1q' was the intended term.

3. `` We have studied the effect of increased osmotic strength of culture media on growth of infectious and non-infectious B. burgdorferi strains B31 and N40.
Relatively small increases in the NaCl concentration of the medium significantly inhibited growth in infectious as well as non-infectious strains.

Growth of low passage, infectious clone B31-4a was more sensitive to increased NaCl concentrations than high passage, non-infectious clone B31-a. Growth of two infectious N40 strains, one low passage (N40-Lp) and one high passage (N40-P31) was more resistant to increased NaCl concentration than growth of infectious B31-4a. Osmotic strength is an important physical parameter for growth of B. burgdorferi in vitro and could influence its ability to adapt and to establish an infection within ticks and mammals.''

PMID: 10048166

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pq
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up
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Virginia of Yore
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Oh, good--because I like sea salt on my veggies!
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serendipity
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This would support the effectiveness of the salt and C protocal for lyme.
[bonk]
I read the begining of your post where you said this related to the salt and C protocal.

I have read to many good reporst on the salt and C protocal not to try it, as it is cheap and I could stand to rasise my blood pressure.
Just wary of the herxes which are reportdly horrific.

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pq
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while i pay "intellectual homage" to this approach, i'm "on the fence" about doing this for prolonged time-periods, and have tried it only for 2-4 days at a time out of desperate need for relief from symptoms of lyme and als, but no vitamin c taken with it, as called for by teh salt/c regimen. the last 7 days, i've done grey salt from brittany. i did a pinch(approx.400-600mg, depending on crystal size) 4-6 times per 24hr. period of time.

some effects = increase in some symptoms and signs, and lessening of others.
the salt intake did quell many symptoms, and i feel somewhat better.

that said, sodium is cancer promoting, and promotes hardening of the arteries.
for one of many solutions to mitigate against these effects of sodium chloride,see emmanuel revici, m.d.
http://tinyurl.com/y6k6s3

the chemistry report from my last lyme-induced, e.r. visit, showed low sodium and chloride,and i was very symptomatic.
best i recall w/o teh report in front of me, sodium was approx. 10% or less below lower limit of normal range. No clue on the chloride level.

so who knows...if, had i done a high dose of salt, i might have saved my self an e.r. visit, worth only the information on my blood chemistry.

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Marnie
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pH 7.6...

Ya mean become a LOT more alkaline...

Good idea (!!!), but the RIGHT mineral?

Food for thought:

A close relationship between Naes (sodium excess)and TBCa (total body calcium) was maintained in the endocrinopathies studied.
This relationship was found in conditions accompanied by either an increment or a

loss of skeletal mass.

PMID: 6766184

Excess sodium intake is linked with high blood pressure and heart disease.

Sodium has an important role in maintaining the water balance within cells and in the function of both nerve impulses and muscles. Any extra sodium is excreted by the kidneys.

Consuming excess sodium may lead to edema or water retention.

Women who consume excess sodium may be at

higher risk for developing osteoporosis even if calcium intake is adequate.

Some evidence suggests that for each teaspoon of salt (2,000 mg of sodium) consumed, considerable calcium is excreted in the urine.

A positive relationship between salt and hypertension is well documented. Salt seems also to adversely affect cardiac structure and function independently from its influence on arterial pressure.

Nature Clinical Practice Cardiovascular Medicine (2004) 1, 24-30
doi:10.1038/ncpcardio0025

AMA calls for measures to reduce sodium intake in U.S. diet

For immediate release
June 13, 2006

CHICAGO -- In an effort to reduce the burden of cardiovascular disease, the American Medical Association (AMA) today passed new policies to help change the way Americans think about salt with the goal of reducing sodium intake throughout America.

"Cardiovascular disease remains the number one killer of Americans. People who reduce dietary sodium intake are taking an important step in preventing future health problems," said AMA Board Member and practicing cardiologist J. James Rohack, MD (audio).

"We hope these recommendations will encourage food manufacturers and restaurants to modify their current practices of adding unhealthy amounts of sodium to their products."


Excess sodium greatly increases the chance of developing hypertension, heart disease, and STROKE

Excessive sodium intake can cause a loss of potassium in the urine, leading to potassium deficiency.

Symptoms of excess sodium include edema, dizziness, and swelling of the legs and face.

Excessive salt intake has also been linked to hypertension, and diets high in sodium may increase the likelihood of liver, heart and kidney disease.

Summary There is accumulating evidence that acetylcholinesterase (AChE) might be involved in the transport of sodium across biological membranes.

Sodium inhibited AChE at low substrate concentrations, whereas the enzyme was

activated by sodium at moderate and high substrate levels.

Break down acetylcholine? Bb's gonna love you for that!

http://www.springerlink.com/content/u6vrg14247005573/

We have known for YEARS that Na kills pathogens. This is why our ancestors salted meat...which is broken down quickly by bacteria.

This is what Dr. Pierre Delbet knew years ago (before the development of vaccines)...salt kills pathogens.

Then he found Mg compds worked even better...

Which is EXACTLY what our body TRIED TO DO at the outset of this disease. Our body pulled Mg out of storage...a lot...to INactivate PFK, to INactivate HMG CoA reductase, to work with calcium to make healthy antibodies, etc.

But we don't have enough to "spare" fast enough.

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pq
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i agree on the effects of excess sodium.
gotta get a systems check--renal, adrenal, entire endocrine syst.....

continuing this discussion/ "thought experiment,"
sodium is in the first series(column) of teh periodic chart of elements.

if sodium has these inhibitory effects in the bodily compartments where its in proportionately highest concentration[extracellular fluid( = intersitial fluid),relative to the quantities of the other series I elements,these other elements in this series might have the same effects in compartments in which they are most abundantly found.


remainder of posted edited.

[ 26. October 2006, 02:38 AM: Message edited by: pq ]

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Jill E.
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Pq and Marnie,

A product called Dioxychlor DC3 by American Biologics was recommended to me several months ago. I purchased it but haven't tried it. It's the liquid tincture, not the IV that some alternative medicine Lyme clinics use.

Here's what intrigues me based on your posts: The ingredients are NaCl with chemically combined oxygen Natrium Muriate.

When I had done a search on Lymenet after purchasing it, the reviews were mostly mediocre.

I figured it was just salt water and put it on the back burner, although it was recommended to me for viruses due to its oxygenating effect.

Anyway, do you think this product might make sense regarding the studies you posted?

I'm familiar with the Salt/C protocol (haven't tried it but have a Lyme pal who has great success on it) and am wondering now if the Dioxychlor might be a very mild version of it.

Thanks,
Jill

--------------------
If laughter is the best medicine, why hasn't stand-up comedy cured me?

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serendipity
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Many of us with lyme have low serum sodium due to adrenal difficulties and low aldosterone and cortisol levels.

I have salted my water, even before I had read about the salt and C protocal, to help increase blood pressure.

On the lymestrategies website, there is an intersting statement that historically we consumed more salt and there were fewer cases of chronic illnesses. This is in response to the argument that increased salt intake is dangerous.

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