Topic: Steere acknowledges chronic Bb infection and vigorous immune response-1998
Greatcod
Unregistered
posted
I will never understand Lyme world. Wonder is the IDSA included this one. The Allen maintains this population is very small.
1: J Immunol. 1998 Feb 15;160(4):1804-10. Links Identification of a T cell subset capable of both IFN-gamma and IL-10 secretion in patients with chronic Borrelia burgdorferi infection.Pohl-Koppe A, Balashov KE, Steere AC, Logigian EL, Hafler DA. Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA.
A novel population of both IFN-gamma- and IL-10-secreting human T cells that differentiate in the presence of exogenous IL-12 in vitro has recently been described. Whether this T cell population exists in vivo is unknown. Borrelia burgdorferi, the etiologic agent of Lyme disease, can induce a chronic infection in the presence of a vigorous humoral immune response. We established T cell lines specific for B. burgdorferi and tetanus toxoid from subjects with chronic B. burgdorferi infection and healthy controls in limiting dilution experiments and assessed proliferation and cytokine secretion. As expected, higher frequencies of B. burgdorferi-specific precursor T cells were observed in Lyme patients compared with controls. In both groups of subjects, T cell lines specific for B. burgdorferi secreted high amounts of IFN-gamma. However, in patients with Lyme disease, 27% of T cell lines secreted not only IFN-gamma but also IL-10, which was only observed in 0.6% of B. burgdorferi-reactive T cell lines generated from controls and in none of the tetanus toxoid-reactive T cell lines generated from either Lyme patients and controls. Single cell PHA cloning confirmed that both cytokines were secreted from one clonally expanded precursor cell. Whole mononuclear cells from B. burgdorferi-infected individuals, but not from controls, secreted IL-12. Moreover, neutralizing anti-IL-12 mAbs inhibited the generation of the IFN-gamma/IL-10 population. These data demonstrate that this novel population of IL-12-induced IFN-gamma/IL-10-secreting T cells is generated in response to chronic B. burgdorferi infection.
PMID: 9469440 [PubMed - indexed for MEDLINE]
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"Borrelia burgdorferi, the etiologic agent of Lyme disease, CAN induce a chronic infection in the presence of a vigorous humoral immune response."
Never read this pub before. that CAN is an interesting word.
Posts: 731 | From Humble,TX | Registered: Feb 2005
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Dave6002
Frequent Contributor (1K+ posts)
Member # 9064
In the above, a research shows "IL-10-deficient (IL-10-/-) mice exhibit up to 10-fold greater clearance of B. burgdorferi from target tissues compared with wild-type mice..."
Bb may stimulate our immune system to produce more IL-10, which is an immune suppressor, so that it can escape from the immune system.
quote: The ratios of IL-4:IFN-gamma and IL-10:TNF-alpha were significantly higher in women. Gender differences in immune reactivity might in part explain the higher incidence of reinfection in women.
Also in this link.
I am wondering if there are more female lymies than male lymies.
If true, IL-10 could be a potential target for Lyme therapy.
Posts: 1078 | From Fairland | Registered: Apr 2006
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