posted
I am on bactrim for bart/babs. But I wonder if my symptoms-chest pressure, foot pain , nightsweats shortness of breath are from lyme. Is bactrim good for lyme? I had a negative blood stain for bart/babs. I'm also havining some very emotional symptoms-like severe PMS-depression, anxiety and agitation.
Anyone know about bactrim-good for lyme?
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valymemom
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posted
Are you taking it by itself? For a time my son took bactim, zith and artemesinin for babs.
You can check Dr. B.'s guidelines for what he uses with bactrim.
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CaliforniaLyme
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posted
I posted for you on that other thread you started about Bactrim a couple of days back that it was very good for LYme and provided an abstract regarding it!!!! It is great for Lyme-
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posted
Californialyme-I reread your post-thanks. I never heard of that abx, but I looked it up-it's a macroglide, like zith. Apparently, bactrim has an effect on lyme, bart and babs.
Maybe that's why I feel so bad today.
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posted
Geneal-I've done 12 weeks of rifampin for bart, 2 rounds of malarone/zith for babs (with art in between), and I had 4 weeks of IV rocephin early on when I first got dx'd. Considering I've been in tx 8 months, I've been hitting bart/babs hard.
What do you think my LLMd could be overlooking? He feels my sx are from bart.
I had gone on a med break to see what sx were from meds-after 3 weeks I started getting the above sx back.
Thanks-shoneys
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treepatrol
Honored Contributor (10K+ posts)
Member # 4117
posted
1: Acta Med Austriaca. 1996;23(3):99-101. Links
Oral treatment of late Lyme borreliosis with a combination of roxithromycin and co-trimoxazole--a pilot study on 18 patients.
Gasser R, Reisinger E, Sedaj B, Horvarth R, Seinost G, Keplinger A, Wendelin I, Klein W. Department of Internal Medicine, University Graz.
In this pilot trial, 18 patients participated in an investigation in which the combined therapy of co-trimoxazole and roxithromycin in late Lyme borreliosis was tested.
The study has been performed as a result of earlier case reports in "The Lancet" where this combination has been used successfully in order to thwart late Lyme disease.
The authors show that 76% of the patients recovered completely. In 2 patients, symptoms could be resolved with i.v. penicillin and 2 did not respond to any antibiotic therapy.
These results show that oral therapy of co-trimoxazole and roxithromycin in combination provides similar results as i.v. antibiotics in earlier studies.
PMID: 8798283
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
treepatrol
Honored Contributor (10K+ posts)
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posted
THE LANCET, VOL. 336, (NOV 10, 1990) p. 1189f.
Oral treatment of late borreliosis with roxithromycin plus co-trimoxazole
SIR, - Early, but not late, Lyme borreliosis has been successfully treated with oral antibiotics such as penicillins, erythromycin, and tetracycline. The possibility of an oral treatement is desirable, especially in view of the great difficulties that arise with long-lasting intravenous treatment in third-world countries.(1, 2) Various workers have shown relapses and failure of treatment in late Lyme borreliosis(adrodermatitits chronica atrophicans, arthritis, neuroborreliosis) even with high doses of intravenous penicillin or ceftriaxone. (2, 3) Treatment that is both orally applicable and effective is certainly needed.(2) Co-trimoxazole is a powerful antibiotic combination to which many microorganisms respond, including the spirochaete Treponema pallidum. Furthermore, it has been show that the new macrolides(such as roxithromycin) show a remarkable antimicrobial activity angaint B burgdorferi.(4,5) It is noteworthy that the blood/brain barrier is highly permeable to roxithromycin. A 30-year-old man infected with B burgdorferi 7 years ago was successfully treated with a combination of roxithromycin(300 mg twice daily) and trimethoprim/sulphamethoxazole(320 mg/1600 mg twice daily) after both intraveous penicillin(20 million IU daily ober 3 weeks) and later ceftriaxone 2 g twice daily for 3 weeks) had failed (figure {not included} ). Both intravenous penicillin and ceftriaxone reduced the symptoms transiently, while IgG remained positive. However, shortly after a 3-week course of roxithromycin/co-trimoxazole all symptoms disappeared and a recent assessment of IgG revealed a negative titre. The recovery of the patient's neurological disorders was strikingly rapid, possibly because of the high permeability of the blood/brain barrier to roxithromycin. Thus, albeit in only 1 patient, we have shown successful oral treatment of late Lyme borreliosis with a combination of roxithromycin and co-trimoxazole.
Robert Gasser, University Laboratory of Physiology, Osford OX1 3 PT, UK
Johann Dusleag, University Medical Clinic, Graz, Austria
1. Steere AC, Malawista SE, Newman J, Spieler PN, Bartenhagen HN. Antibiotic therapy in Lyme disease. Ann Intern Med 1990;93:1-8.
2. Weber, K, Preac-Mursic V, Neubert V, et al. Antibiotic therapy of early European Lyme borreliosis and acrodermatitis chronica athrophicans. Ann NY Acad Sci 1988; 325-45
3.Dattwyler RJ, Halperin JJ, Volkman DJ, Luft BJ. Treatment of later Lyme borreliosis - randomisesd comparison of ceftriaxone and penicillin. Lancet 1988: i: 1191-94
4. Preac-Mursic V, Gross B, Suiss E, Wilske B, Schierz G. Comparative antimicrobial activity of the new macrolides against Borrelia burgdorferi. Eur J Clinical Microbiol Inf Dis 1989; 8: 651-53
5. Steere AC, Grodzicki RL, Kornblatt AN, et al. The spirochaetal etiology of Lyme disease. N Engl J Med 1983; 308: 733-40.
_________________________ [note from poster] In response to this article a few weeks later there was an article from two physicians of the University Hospital of Frederiksberg, Denmark (Departement of Rheumatology and Clinical Microbiology) entitled with: Late treatment of chronic Lyme arthritis. They discussed a similar case and also tried this combination treatment of Gasser and Dueslag. They also were successful and came to the conclusion that, "combined therapie with roxithromycin and co-trimoxazole may prove effectiv in chronic Lyme arthritis where conventional antibiotics have failed."
Spirochaetal infections have been successfully treated with penicillin; more recently, erythromycin has been used in cases with known penicillin allergy. The discovery of the spirochaete Borrelia burgdorferi and the elaboration of a new generation of macrolides with properties that differ from older macrolides have led to new ways of treating spirochaetal disease with these compounds. This paper presents data on the in vitro and in vivo efficacy of a combination of roxithromycin and co-trimoxazole against B. burgdorferi.
In vitro (checkerboard technique; B. burgdorferi strain B31; modified BSK II medium) it was found that while roxithromycin showed excellent efficacy against B. burgdorferi (MIC 0.031 mg/l), co-trimoxazole had no effect. However, the combination of both chemotherapeutics led to a minor synergistic effect, decreasing the MIC for roxithromycin by one dilution step at concentrations of co-trimoxazole from 256 to 8 mg/l. In addition, a clearly reduced growth of microorganisms was seen at concentrations of roxithromycin as low as 0.015 mg/l in combination with 256 to 4 mg/l co-trimoxazole, when compared to the positive controls.
Most interestingly, however, the motility of B. burgdorferi was markedly reduced even when the two drugs were combined at very low concentrations. In an in vivo, non-randomised, open, prospective pilot study it was found that of 17 patients with confirmed late Lyme borreliosis (stage II/III), treated with combined roxithromycin (300 mg b.i.d.) and co-trimoxazole for 5 weeks, 13 (76%) recovered completely by the end of treatment, and four continued to have symptoms on follow-up at 6 and 12 months. This success rate is similar to that seen with i.v. penicillin and ceftriaxone. It appears that the reduced motility of B. burgdorferi makes the pathogen more accessible to the immune system.
Publication Types: Clinical Trial
PMID: 7782115 [PubMed - indexed for MEDLINE]
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
posted
Thanks teepatrol-I know about lyme, how about for bart or babs?
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treepatrol
Honored Contributor (10K+ posts)
Member # 4117
posted
quote:Originally posted by shoney: Thanks teepatrol-I know about lyme, how about for bart or babs?
Bartonella endocarditis is usually indolent and culture negative, and thus, diagnosis is often delayed, resulting in a mortality rate higher than that for some other forms of endocarditis. It was previously demonstrated (37) that patients with Bartonella endocarditis have a higher death rate and undergo valvular surgery more frequently than patients with endocarditis caused by other pathogens. Selection of an adequate treatment regimen is critical, even when Bartonella infection is suspected but not yet documented. Among 101 patients with Bartonella endocarditis recently described in a retrospective study (83), 82 received aminoglycosides for a mean of 15 � 11 days with either a beta-lactam (64 cases) or other antibiotic(vancomycin,doxycycline,rifampin, or co-trimoxazole). Seventy-four of the 82 patients who received an aminoglycoside recovered, whereas 13 of 19 of those who received no aminoglycoside recovered (P = 0.02) (84).
Among the patients treated with aminoglycosides,65 of the 69 who recovered had received aminoglycosides for 14 or more days, whereas 9 of the 13 patients who recovered had been treated for less than 14 days (P = 0.02). Patients receiving an aminoglycoside were more likely to recover fully and, if they were treated for at least 14 days, were more likely to survive,confirming the important role of this antibiotic in the treatment of Bartonella endocarditis (83).
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-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
posted
So good for lyme, not so good for Bart? Although 13/19 recovered also (68%) vs 74/82 (90%). I never heard of a LLMD using aminoglycosides for bart. Rifampin is usually the popular one now
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Geneal
Frequent Contributor (5K+ posts)
Member # 10375
posted
Shoney,
I did three months straight of malarone at 4 x a day along with zith and bactrim.
I felt that I hit babs pretty hard too....but obviously not hard enough.
I have babs symptoms back.
When I finish rifampin, I am going back on malarone at 4 x a day and maybe pulse some art too for another three months.
What I meant is that some of these co-infections are so hard to get rid of....
Search babesia treatment. Many people here have had to treat for babs over and over.
I didn't mean to insult you or your LLMD....
Sorry if I offended you.
If my memory is correct, bart can be a difficult bug to get rid of too.
Hugs,
Geneal
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groovy2
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posted
Hi All
I used Bactrim 8 months for Babs-- It helped Alot-- Herxed BIG Time -Ouch -
Make sure to drink Lots of water--Jay-
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