disturbedme
Frequent Contributor (1K+ posts)
Member # 12346
posted
Just wondering if anyone takes this stuff?
It's supposed to be a lymph drainage concoction of sorts -- It's a liquid that you drink. My LLMD suggested it because Andrographis has been making me herx and this cleans out the lymph system which will clean out the toxins in the body.
Thanks!
-------------------- One can never consent to creep when one feels an impulse to soar. ~ Helen Keller
My Lyme Story Posts: 2965 | From Land of Confusion (bitten in KS, moved to PA, now living in MD) | Registered: Jun 2007
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dmc
Frequent Contributor (1K+ posts)
Member # 5102
posted
When I googled Four Plus One it came up as hip-hop group...an " initiative arose against the backdrop of Argentina's financial crisis"
didn't find a product
Posts: 2675 | From ct, usa | Registered: Jan 2004
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disturbedme
Frequent Contributor (1K+ posts)
Member # 12346
posted
quote:Originally posted by dmc: When I googled Four Plus One it came up as hip-hop group...an " initiative arose against the backdrop of Argentina's financial crisis"
didn't find a product
This is what I got from my LLMD and it says on the label:
"Four + One
16 Fluid Ounces Burdock Root, Sheep Sorrel Herb, Slippery Elm, Turkey Rhubarb Root & Red Clover Herb" (are the ingredients)
Yeah, it may not be a well known as it doesn't look like it's made from a big company or anything.
It has a phone number on the bottom, and says NY.
-------------------- One can never consent to creep when one feels an impulse to soar. ~ Helen Keller
My Lyme Story Posts: 2965 | From Land of Confusion (bitten in KS, moved to PA, now living in MD) | Registered: Jun 2007
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disturbedme
Frequent Contributor (1K+ posts)
Member # 12346
-------------------- One can never consent to creep when one feels an impulse to soar. ~ Helen Keller
My Lyme Story Posts: 2965 | From Land of Confusion (bitten in KS, moved to PA, now living in MD) | Registered: Jun 2007
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treepatrol
Honored Contributor (10K+ posts)
Member # 4117
posted
Not same name but same herbs. Essiac� contains a combination of herbs, including burdock root ( Arctium lappa ), sheep sorrel ( Rumex acetosella ), slippery elm inner bark ( Ulmus fulva ), and Turkish rhubarb ( Rheum palmatum ). The original formula was developed by the Canadian nurse Rene Caisse (1888-1978) in the 1920s ("Essiac" is Caisse spelled backwards). The recipe is said to be based on a traditional Ojibwa (Native American) remedy, and Caisse administered the formula by mouth and injection to numerous cancer patients during the 1920s and 1930s. The exact ingredients and amounts in the original formulation remain a secret.
During investigations by the Canadian government and public hearings in the late 1930s, it remained unclear if Essiac� was an effective cancer treatment. Amidst controversy, Caisse closed her clinic in 1942. In the 1950s, Caisse provided samples of Essiac� to Dr. Charles Brusch, founder of the Brusch Medical Center in Cambridge, Massachusetts, who administered Essiac� to patients (it is unclear if Brusch was given access to the secret formula). According to some accounts, additional herbs were added to these later formulations, including blessed thistle ( Cnicus benedictus ), red clover ( Trifolium pratense ), kelp ( Laminaria digitata ), and watercress ( Nasturtium officinale ).
A laboratory at Memorial Sloan-Kettering Cancer Center tested Essiac� samples (provided by Caisse) on mice during the 1970s. This research was never formally published, and there is controversy regarding the results, with some accounts noting no benefits, and others reporting significant effects (including an account by Dr. Brusch). Questions were later raised of improper preparation of the formula. Caisse subsequently refused requests by researchers at Memorial Sloan-Kettering and the U.S. National Cancer Institute for access to the recipe.
In the 1970s, Caisse provided the formula to Resperin Corporation Ltd., with the understanding that Resperin would coordinate a scientific trial in humans. Although a study was initiated, it was stopped early amidst questions of improper preparation of the formula and inadequate study design. This research was never completed. Resperin Corporation Ltd., which owned the Essiac� name, formally went out of business after transferring rights to the Essiac� name and selling the secret formula to Essiac Products Ltd., which currently distributes products through Essiac� International.
Despite the lack of available scientific evidence, Essiac� and Essiac-like products (with similar ingredients) remain popular among patients, particularly in those with cancer. Essiac� is most commonly taken as a tea. A survey conducted in the year 2000 found almost 15% of Canadian women with breast cancer to be using Essiac�. It has also become popular in patients with HIV and diabetes, and in healthy individuals for its purported immune enhancing properties, although there is no reliable scientific research in these areas.
There are more than 40 Essiac-like products available in North America, Europe, and Australia. Flor-essence� includes the original four herbs (burdock root, sheep sorrel, slippery elm bark, Turkish rhubarb) as well as herbs that were later added as "potentiators" (blessed thistle, red clover, kelp, watercress). Virginias Herbal E� contains the four original herbs along with echinacea and black walnut. Other commercial formulations may include additional ingredients, such as cat's claw ( Uncaria tomentosa ).
SynonymsReturn to top
Burdock root (Arctium lappa) synonyms/related terms: Akujitsu, anthraxivore, arctii, Arctium minus , Arctium tomentosa , bardana, Bardanae Radix, bardane, bardane grande (French), beggar's buttons, burr, burr seed, chin, clot-burr, clotbur, cocklebur, cockle button, cocklebuttons, cuckold, daiki kishi, edible burdock, fox's clote, grass burdock, great bur, great burdock, great burdocks, gobo (Japan), Grosse klette (German), happy major, hardock, hare burr, hurrburr, Kletterwurzel (German), lampazo (Spanish), lappola, love leaves, niu bang zi, oil of lappa, personata, Philanthropium, thorny burr, turkey burrseed, woo-bang-ja, wild gobo.
Slippery elm inner bark (Ulmus fulva) synonyms/related terms: Indian elm, moose elm, red elm, rock elm, slippery elm, sweet elm, Ulmaceae , Ulmi rubrae cortex, Ulmus fulva Michaux, Ulmus rubra , Winged elm.
Turkish rhubarb (Rheum palmatum) synonyms/related terms: Baoshen pill, Canton rhubarb, Chinesischer Rhabarber (German), Chinese rhubarb, chong-gi-huang, common rhubarb, da-huang, Da Huang, daio, Da huang Liujingao, English Rhubarb, Extractum Rhei Liquidum, Himalayan Rhubarb, Indian rhubarb, Japanese rhubarb, Jiang- Zhi Jian-Fel Yao (JZJFY), Jinghuang tablet, medicinal rhubarb, pie rhubarb, Polygonaceae (family), Pyralvex, Pyralvex Berna, racine de rhubarbee (French), RET (Rhubarb extract tablet), rhabarber, rhei radix, rhei rhizoma, rheum, Rheum australe , Rheum emodi Wall, Rheum officinale Baill, Rheum rhabarbarum , Rheum rhaponticum L., Rheum tanguticum Maxim, Rheum tanguticum Maxim. ex. Balf., Rheum tanguticum Maxim L., Rheum undulatum , Rheum x cultorum , Rheum webbianum (Indian or Himalayan rhubarb), rhizoma, rheirhubarbe de chine (French), rhubarb, rubarbo, ruibarbo (Spanish), shenshi rhubarb, tai huang, Turkey rhubarb.
EvidenceReturn to top
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Uses based on scientific evidence Grade* Cancer
There are no properly conducted published human studies of Essiac� for cancer. A laboratory at Memorial Sloan-Kettering Cancer Center tested Essiac� on mice during the 1970s, although results were never formally published and remain controversial. Questions were raised of improper preparation of the formula. A human study was started in Canada in the late 1970s but was stopped early due to concerns about inconsistent preparation of the formula and inadequate study design. In the 1980s, the Canadian Department of National Health and Welfare collected information about 86 cancer patients treated with Essiac�. Results were inconclusive (17 patients had died at the time of the study, inadequate information was available for eight patients, "no benefits" were found in 47 patients, five reported reduced need for pain medications, and one noted subjective improvement). Most individuals also received other cancer treatments such as chemotherapy, making the effects of Essiac� impossible to isolate.Currently, there is not enough evidence to recommend for or against the use of this herbal mixture as a therapy for any type of cancer. Different brands may contain variable ingredients, and the comparative effectiveness of these formulas is not known. None of the individual herbs used in Essiac� has been tested in rigorous human cancer trials (rhubarb has shown some anti-tumor properties in animal experiments; slippery elm inner bark has not; sheep sorrel and burdock have been used traditionally in cancer remedies). Numerous individual patient testimonials and reports from manufacturers are available on the Internet, although these cannot be considered scientifically viable as evidence. Individuals with cancer are advised not to delay treatment with more proven therapies. C
*Key to grades A: Strong scientific evidence for this use; B: Good scientific evidence for this use; C: Unclear scientific evidence for this use; D: Fair scientific evidence against this use; F: Strong scientific evidence against this use.
Grading rationale
Uses based on tradition or theory The below uses are based on tradition or scientific theories. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. AIDS/HIV, appetite stimulant, arthritis, asthma, blood cleanser, chelating agent (heavy metals), chronic fatigue syndrome, detoxification, diabetes, energy enhancement, head/neck cancers, Hodgkin's disease, immune system enhancement, kidney diseases, leukemia, longevity, Lyme disease, lymphoma, multiple myeloma, non-Hodgkin's lymphoma, nutritional supplement, supportive care in advanced cancer patients, paralysis, reduction of chemotherapy side effects, systemic lupus erythematosus, thyroid disorders, well-being.
DosingReturn to top
The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.
Adults (over 18 years old) Historically, Essiac�was administered by mouth or injection. The most common current use is as a tea. There are no reliable published human studies of Essiac� or Essiac-like products, and safety or effectiveness has not been established scientifically for any dose. Instructions for tea preparation and dosing vary from product to product. Patients are advised to read product labels and speak with their cancer healthcare professional before starting any new therapy, such as Essiac� or Essiac-like products.
Children (under 18 years old) There is not enough scientific data available to recommend the safe use of Essiac� or Essiac-like products in children.
SafetyReturn to top
The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.
Allergies There are no reports of allergy to Essiac� in the published scientific literature, although reactions individuals with allergy to members of the Asteraceae/Compositae family, such as ragweed potentially can occur due to any of the included herbs. Anaphylaxis has been reported after rhubarb leaf ingestion, and there are reports of allergic reactions to sorrel products taken by mouth. Contact dermatitis (skin rash after direct contact) has been reported with exposure to burdock, slippery elm bark, and rhubarb leaves. Cross-sensitivity to burdock may occur in, chrysanthemums, marigolds, and daisies.
Side Effects and Warnings The safety of Essiac� is not well studied scientifically. Safety concerns are based on theoretical and known reactions associated with herbal components of Essiac�: burdock root ( Arctium lappa ), sheep sorrel ( Rumex acetosella ), slippery elm bark ( Ulmus fulva ), and Turkish rhubarb ( Rheum palmatum ). However, the safety and toxicities of these individual herbs are also not well studied. Various Essiac-like products may contain different or additional ingredients, and patients are advised to carefully review product labels.
Potentially toxic compounds present in Essiac�include tannins, oxalic acid, and anthraquinones. Tannins, present in burdock, sorrel, rhubarb, and slippery elm, may cause stomach upset, and in high concentrations may lead to kidney or liver damage. In theory, long-term use of tannins may increase the risk of head and neck cancers, although there are no documented human cases.
Oxalic acid contained in rhubarb, slippery elm, and sorrel, can cause serious adverse effects when taken in high doses (particularly in children). Oxalic acid toxicity/poisoning may be associated with nausea, vomiting, mouth/throat burning, dangerously low blood pressure, blood electrolyte imbalances, seizure, throat swelling that interferes with breathing, and liver or kidney damage. Deaths from oxalic acid poisoning have been reported in an adult man eating soup containing sorrel and in a four year-old child eating rhubarb leaves. The lethal dose of oxalic acid for adults has been estimated as 15 to 30 grams, although doses as low as 5 grams may be fatal. The amount of oxalic acid in Essiac� preparations is not known. In cases of suspected oxalic acid poisoning, medical attention should be sought immediately. Regular intake of oxalic acid may increase the risk of kidney stones.
Anthraquinones in rhubarb root or sheep sorrel may lead to diarrhea, intestinal cramping, and loss of fluid and electrolytes (such as potassium). Use of rhubarb may lead to discoloration of the urine (bright yellow or red), or of the inner mucosal surface of the intestine (a condition called melanosis coli). Fluoride poisoning has been reported with the use of rhubarb fruit juice. Rhubarb products manufactured in China have been contaminated with heavy metals. Chronic use of rhubarb products may lead to dependence.
Based on animal research and limited human study, burdock may cause either increases or reductions in blood sugar levels. Caution is advised in patients with diabetes or hypoglycemia, and in those taking drugs, herbs, or supplements that affect blood sugar. Serum glucose levels may need to be monitored by a healthcare professional, and medication adjustments may be necessary. Diuretic effects (increasing urine flow) and estrogen-like effects have been reported with oral burdock use in patients with HIV.
Reports of anticholinergic reactions (such as slow heart rate and dry mouth) with the use of burdock products in the 1970s are believed to be due to contamination with belladonna alkaloids, which resemble burdock and can be introduced during harvesting. Burdock itself has not been found to contain constituents that would be responsible for these reactions.
Pregnancy and Breastfeeding There is not enough scientific evidence to recommend the safe use of Essiac� or Essiac-like products during pregnancy and breastfeeding, and there are potential risks from the included herbs. Oxalic acid and anthraquinone glycosides in the included herbs may be unsafe during pregnancy. Rhubarb and burdock may lead to contraction of the uterus; some publications note that whole slippery elm bark can lead to abortion, although there is limited supporting scientific evidence.
InteractionsReturn to top
Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.
Interactions with Drugs Essiac� interactions are not well studied scientifically. Most potential interactions are based on theoretical and known reactions associated with herbal components of Essiac�: burdock root ( Arctium lappa ), sheep sorrel ( Rumex acetosella ), slippery elm bark ( Ulmus fulva ), and Turkish rhubarb ( Rheum palmatum ). However, the interactions of these individual herbs are also not well studied. Various Essiac-like products may contain different or additional ingredients, and patients are advised to carefully review product labels.
Essiac� may interfere with the way the body processes certain drugs using the liver's "cytochrome P450" enzyme system. As a result, the levels of these drugs may be increased in the blood, and may cause increased effects or potentially serious adverse reactions. Patients using any medications should check the package insert and speak with a healthcare professional or pharmacist about possible interactions. This is based on a report of one patient in a research study taking the experimental drug DX-8951f (metabolized by CYP3A4 and CYP1A2), who experienced toxic side effects and drug clearance that was 4 to 5 times slower than in other patients. This patient was also taking "Essiac tea," although further details are not available, and it is not clear if the patient was taking Essiac� or an Essiac-like product.
Anthraquinones in rhubarb root or sheep sorrel may lead to diarrhea, dehydration, or loss of electrolytes (such as potassium), and may increase the effects of other laxative agents. Burdock has been associated with diuretic effects (increased urine flow) in one human report, and in theory may cause excess fluid loss (dehydration) or electrolyte imbalances (such as changes in blood potassium or sodium levels). These effects may be increased when burdock is taken at the same time as diuretic drugs such as chlorothiazide (Diuril�), furosemide (Lasix�), hydrochlorothiazide (HCTZ), or spironolactone (Aldactone�). The laxative and diuretic properties of herbs in Essiac� may lead to low potassium blood levels that are potentially dangerous in people taking digoxin or digitoxin.
Based on animal research and limited human study, burdock may either lower or raise blood sugar levels. Caution is advised when using medications that may also affect blood sugar. Patients taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional. Medication adjustments may be necessary.
Based on limited human evidence that is not entirely clear, burdock may have estrogen-like properties, and may act to increase the effects of estrogenic agents including hormone replacement therapies such as Premarin� or birth control pills.
Interactions with Herbs and Dietary Supplements Based on one human report, Essiac� may interfere with the way the body processes certain herbs or supplements using the liver's "cytochrome P450" enzyme system. As a result, the levels of other herbs or supplements may become too high in the blood. It may also alter the effects that other herbs or supplements possibly have on the P450 system.
Anthraquinones in rhubarb root or sheep sorrel may lead to diarrhea, dehydration, or loss of electrolytes (such as potassium), and may increase the effects of agents with possible laxative properties.
Burdock has been associated with diuretic effects (increased urine flow) in one human report, and in theory, may cause excess fluid loss (dehydration) or electrolyte imbalances (such as changes in blood potassium or sodium levels) when used with other diuretic herbs or supplements.
The laxative and diuretic properties of herbs in Essiac� may lead to low potassium blood levels that are potentially dangerous in people taking cardiac glycoside-containing herbs.
Based on animal research and limited human study, burdock may either lower or raise blood sugar levels. Caution is advised when using herbs or supplements that can also alter blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.
Because burdock may contain estrogen-like chemicals, the effects of other agents believed to have estrogen-like properties may be altered.
In theory, use of rhubarb and sheep sorrel may decrease the absorption of minerals such as calcium, iron, and zinc.
-------------------- Do unto others as you would have them do unto you. Remember Iam not a Doctor Just someone struggling like you with Tick Borne Diseases.
posted
My LLMD recommended this for herxing as well. I wonder if we're seeing the same doc? He recommended Jean's Greens Four Plus One. I elected to purchase mine directly from Jean's for only $9 per bottle, as opposed to the $22 per bottle the doc was charging! I also considered just purchasing the dried herbs and making my own Essiac.
I took one bottle and then stopped. Can't say one way or the other whether it helped. I still herxed and felt like death warmed over anyway. And that was just herxing from Doxy alone.
The reason why I stopped was because of the potentially high oxalate levels in the herbs. I got scared because I have a history of calcium oxalate kidney stones.
My doc also suggested that instead of Four Plus One, I could try Rechts Regulat instead. I do have a bottle of Rechts Regulat in my cupboard but have not started it yet. I'm having to take such baby steps as far as introducing remedies, meds, etc.
Posts: 503 | From Maryland | Registered: Oct 2007
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disturbedme
Frequent Contributor (1K+ posts)
Member # 12346
posted
FuzzySlippers - it does sound like we have the same doc! Cool!
Thanks for your input. I am glad to know someone else has taken it; that's basically what I wanted to hear was that someone else had taken/tried it. I'm sorry it didn't help your herxes though.
I'll have to see now if it helps me at all.
He recommended it because I've been herxing off of Andrographis really badly.
-------------------- One can never consent to creep when one feels an impulse to soar. ~ Helen Keller
My Lyme Story Posts: 2965 | From Land of Confusion (bitten in KS, moved to PA, now living in MD) | Registered: Jun 2007
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posted
You're welcome, disturbed. For what it's worth, I still plan to try the Four + One again because I bought a bunch of bottles from Jean's Greens. lol I think I'll just have to really increase my magnesium while taking it to help offset the oxalate issue for me.
Anyway, it's really hard sometimes to gauge what's helping and/or what we're reacting to. With Lyme we're affected in so many ways that it makes the symptom/relief detective work frustrating. Therefore, I don't want to exclude something like Essiac based upon my mere one week's worth of usage. One week surely wasn't enough to make an assessment for efficacy.
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