Topic: Prostate cancer for RESEARCHERS re: photodyamic therapy!
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Dear Doctors,
Bb has a PKC *inhibitor*, it's PKCD isn't it?
Gamma/delta T cells are greatly impacted...infected... and delta T cells can't do their job.
I've suspected this for several months.
So this comes as no surprise:
"We have established that *activation* of PKCd, a novel PKC isozyme, induces apoptosis through a caspase-3-*independent* mechanism in androgen-sensitive prostate cancer cells."
PDT is an established anticancer modality utilizing the photogeneration of reactive oxygen species =ROS to kill the cancer cells and
hypericin is a promising photosensitizer for the treatment of bladder tumors.
In this paper we characterize the signaling pathways and the mechanisms leading to the
up-regulation of the antioxidant enzyme heme oxygenase =HO-1 in PDT treated cancer cells.
We show that PDT engages the p38MAPK and PI3K signaling cascades for HO-1 induction.
p38MAPK inhibitors or small interfering RNA =siRNA for p38MAPK suppress HO-1 induction after PDT and complete repression is attained when p38 and PI3K antagonists are combined.
Blocking these signaling pathways increases additively the propensity of the cells to undergo PDT-induced apoptosis, mirroring the effect of HO-1 silencing.
Conversely, increasing HO-1 protein level by hemin prior to irradiation is cytoprotective.
HO-1 stimulation by PDT is dependent on transcription and de novo protein synthesis and it is preceded by the nuclear accumulation of the Nrf2 transcription factor, which is reduced by inhibitors of p38MAPK and PI3K.
Altogether these results indicate that stimulation of HO-1 expression by hypericin-PDT is a cytoprotective mechanism governed by the p38MAPK and PI3K pathways, likely through the control of the nuclear availability of the Nrf2 pool.
Finally, the expression of PDCD4 and maspin inversely correlated with mir-21 expression in human breast tumor specimens, indicating the potential
regulation of PDCD4 and maspin
by mir-21 in these tumors.
Taken together, the results suggest that, as an oncogenic miRNA, mir-21 has a role not only in tumor growth but also in invasion and tumor metastasis by targeting multiple tumor/metastasis suppressor genes.
Therefore, suppression of mir-21 may provide a novel approach for the treatment of advanced cancers."
Cell Research advance online publication 12 February 2008; doi: 10.1038/cr.2008.24.
CD4 cells must have "working" gamma/delta T cells.
Role for DNA methylation in the control of cell type specific maspin , a tumor suppressor, expression." Nature Genetic31 2:175-179
BTW...PANCREATIC cancer:
"Except for kwashiorkor, the human pancreas is relatively unaffected by nutritional deficiency (1 ); however, studies in a variety of experimental systems document that the pancreas is affected by dietary deficiency of both methyl donors and folate."
(NaturalNews) Researchers at Thomas Jefferson University in Philadelphia have discovered that an extract of nigella sativa seed oil, known as thymoquinone, can remedy one of the most virulent and difficult to treat cancers: pancreatic cancer.
The extract does this by blocking pancreatic cell growth, and actually enhancing the built-in cellular function that causes programmed cell death, or apoptosis.
Common Name Black seeds, *Black cumin*, fennel flower, black caraway, nutmeg flower, Roman coriander, black onion seed, kalonji..
"Discovered in Tutankhamen's tomb, Black Cumin Seed played an important role in ancient Egyptian culture. Although its exact role is unknown, items entombed with a king were carefully selected to assist him in the afterlife. Because of its many uses, Black Cumin has earned the Arabic approbation ``habbatul barakah'' which means ``the seed of blessing.''
"One reason that is often given for the medicinal value of black cumin seed extract is its richness in polyunsaturated fatty acids, which help to produce prostaglandin E1."
"Inhibition of In Vivo Insulin Secretion by Prostaglandin E1"
Insulin ACTIVATES PFK...
Bb is PFK dependent.
"inhibits conversion of AA to PGE2 = Oleic Acid =olive oil"
Where there's a will...there's a way.
[ 19. June 2008, 12:09 PM: Message edited by: Marnie ]
Posts: 9430 | From Sunshine State | Registered: Mar 2001
| IP: Logged |
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
This is for Dr. B and all you guys on this board...
HEADS UP.
Posts: 9430 | From Sunshine State | Registered: Mar 2001
| IP: Logged |
The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:
The
Lyme Disease Network of New Jersey 907 Pebble Creek Court,
Pennington,
NJ08534USA http://www.lymenet.org/
UBBFriend: Email this page to someone!
Printer-friendly view of this topic