posted
Surprise! This came in the mail today and was done by NW Pathology not Igenex. DH is at the dermatologist now for his appointment. He wanted me to post this and see what you all thought about his report. Please make comments for him. TIA
Final diagnosis: Skin, left superior arm: Superficial and deep perivascular and interstitial dermatitis
Comment: The histologic differential would include a hypersensitivity reaction to a medication or possibly interstitial granuloma annulare. There are not interface or epidermal changes to suggest erythema mulitforme. There is no spongiosis. The gyrate erythema such as erythema annular centrifugum could also be included in the differential, but this is felt to be less likely.
Microscopic description: Sections demonstrate a punch biopsy of skin to the deep reticular dermis. The epidermis is largely unremarkable and there is a superficial and deep perivascular inflammatory infiltrate comprised of lymphocytes primarily. Occasional histiocytes are evident. There is also an increase in the number of mast cells. A C-Kit stain in performed to evaluate the mast cell population. Eosinophils are not consipicuously present. There is no interface dermatitis and no epidermal necrosis is present. ----------------------------------- end of report
My DH was not on medications prior to his rash therefore we do not believe a hypersensitivity reaction is possible cause.
I looked up interstitial granuloma annulare online and found a pic of a guy with the same long lasting red circular rash in same area. I also saw an interesting article that seemed to imply from first glance Borrelia infection could set it off so to speak.
edited to add: Wondering too if melanoma could set it off. He is having some suspicious moles removed today. YIKES!
Will check back later on to see if you have anything to share.
-------------------- IGeneX WB on 9.09: IGG:31.IND,34.IND,41+,66+ IGM:39IND,41++ on 9.09 same on 1.10 ME/CFS, CPN, EBV, HHV6 Posts: 77 | From Washington | Registered: Apr 2009
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Pinelady
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posted
Glad your researching. Let us know what he says. I never had a rash but I know it is called GA. I know silver stain and the high powered scopes will find borrelia if present, turns them brown. Don't know if they used the right stain. I would like to know what the doctor says if you find anything. Very interesting,Thanks.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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Dekrator48
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posted
Hi,
My daughter has granuloma annulare and she also has lyme and probably coinfections...she hasn't started treatment yet.
-------------------- The fibromyalgia I've had for 32 years was an undiagnosed Lyme symptom.
"For I know the plans I have for you", declares the Lord, "plans to prosper you and not to harm you, plans to give you hope and a future". -Jeremiah 29:11 Posts: 6076 | From Pennsylvania, USA | Registered: Nov 2008
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posted
LOL ... while I was editing my post to make it clearer and add facts you two replied. Thanks Pinelady & Dekrator48. I started to read the study you shared but may have to finish reading after I cook our dinner.
I hope you understand I wasn't trying to get pushy by putting your name in the title Pinelady. It's just I remembered it was you that specifically had asked about that punch biopsy and I wanted to make sure you saw it. Good to know you did. LOL Thanks both of you. Until later then ...
-------------------- IGeneX WB on 9.09: IGG:31.IND,34.IND,41+,66+ IGM:39IND,41++ on 9.09 same on 1.10 ME/CFS, CPN, EBV, HHV6 Posts: 77 | From Washington | Registered: Apr 2009
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-------------------- IGeneX WB on 9.09: IGG:31.IND,34.IND,41+,66+ IGM:39IND,41++ on 9.09 same on 1.10 ME/CFS, CPN, EBV, HHV6 Posts: 77 | From Washington | Registered: Apr 2009
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posted
Not sure why this was done, but my impression is that derms are not any more likely to detect lyme than the other specialists, and they hardly ever do.
I went to a derm with an atypical lyme rash and was told that it absolutely was not lyme related. Wrong. So I declined a subsequent biopsy because it was clear they were ignorant and closeminded.
Posts: 8430 | From Not available | Registered: Oct 2000
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Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
You got it right Lou.
I have read on autopsy studies of animals it is
common to find it in the skin. Hence we have
vitamin D deficiency, they use what we need to
metabolize this hormone. I would be very
surprised if a lab other than a Lyme specific lab
like IgeneX would find them. I even know of a
person that I think died from it and as a result
they got a COD unknown. That being said I would
just take my results to my LLMD.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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posted
Thanks Lou & Pinelady for your comments. It all helps to get us thinking straight.
I do wish the derm would have tested for D25 when she ran all the other blood tests. If I would have known she was going to run all those blood tests I would have told DH to request it.
That is very interesting Pinelady: a reason we tend to be vit. D deficient. Thinking it seems the bugs are very clever at weakening our immune system by doing so. That way they will less likely be detected.
Well, sadly it appears all the testing the derm did is for nothing then. So we know little more than when we began. That is very frusterating.
I do get it. That this is nothing new. Quite a medical system we have with the tick diseases becoming more prevalent and the lousy diagnosing insuring people are suffering needlessly physically, mentally and financially.
I received a list of LLMD's in my email and went over them. Not a very good selection in WA. which I suspected would be so. We will see about getting on board with one ASAP. Unfortunately the ones that look most promising are in major traffic areas in big cities. UGH!
By the way, his rash is slightly darker today so maybe I can get some better pics. The ones I took before are useless really cause the rash was so faded from cortisteroid cream.
Dekrator48 ... we read the article you shared last night. It was a challenge as we are not medical folks plus brain fog plagues me.
I am wondering if no mention of those pseudorossettes was made by the lab recent tests on DH do you suppose: A.) There weren't any to see. or is it B.) The lab didn't use the right procedure to detect them.
The FFM procedure seems to be the difference. Do I have it right? Most labs just do the PCR and not the FFM? Please set me straight if I have it twisted. Does Igenex do this FFM? Is that the difference?
Thanks again!
-------------------- IGeneX WB on 9.09: IGG:31.IND,34.IND,41+,66+ IGM:39IND,41++ on 9.09 same on 1.10 ME/CFS, CPN, EBV, HHV6 Posts: 77 | From Washington | Registered: Apr 2009
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Pinelady
Frequent Contributor (5K+ posts)
Member # 18524
posted
Silvadene cream would be your best bet. It is very expensive though. And requires a script.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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