Lauralyme
Frequent Contributor (1K+ posts)
Member # 15021
posted
My KPU result was 8 which was well within range.....being below 15 but my LLMD is treating me regardless. He said we are so deficient in zinc that we will need to supplement zinc for years.
-------------------- Fall down seven times, get up eight ~Japanese proverb Posts: 1146 | From west coast | Registered: Mar 2008
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bettyg
Unregistered
posted
what does KPU stand for; neuro lyme acting up.
linky, lymenet will NOT let me open your pm you sent me tonight, so i'll have to get back to you when they fix this specific problem area.
i could read it in my home email box; interesting!! god's country is right on that part of the state.
so that's why you haven't heard back from me ...
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linky123
Frequent Contributor (1K+ posts)
Member # 19974
posted
Hi Betty,
KPU stands for kryptopyrroles. If a person has
pyroluria, they will lose KPUs through their
urine, resulting in zinc and B6 deficiency.
Thanks
Linky
Posts: 2607 | From Hooterville | Registered: Apr 2009
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posted
Which lab did you use? My test was positive,but many people with neg results are are still doing the protocal. Every once in a while almost all my symtoms lift then I get slammed again. I am having a great morning. Gives me much hope. Its been a loooooog hard 27 yrs,also with lots of blessings and learning. Joyce
Posts: 905 | From Santa Cruz,Calif | Registered: Aug 2005
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bettyg
Unregistered
posted
linky, thx for the explanation.
could you copy the entire name and show it in subject line for others not familiar like me? thanks so much my new friend
just click on pencil, 3rd icon to right of you name for subject and text to add/delete, etc. big thanks.
we use too much of abbreviations and we have just too much lyme fog and no comprehension to understand.
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SForsgren
Frequent Contributor (1K+ posts)
Member # 7686
posted
Did you do the 24 hour collection? Did you stop all B's, zinc, etc. for 5-7 days beforehand?
You need to follow the collection guidelines here:
posted
LabCorp also offers the test. I don't know if they are as reliable though. I have to get this test done and have been debating whether to use them or Bio-Center Labs.
brooke
[ 07-31-2009, 10:25 PM: Message edited by: brooke ]
Posts: 117 | From PA | Registered: Aug 2008
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posted
I used Bio-labs and mine was positive. I have heard of negative results from all labs. Some with negs are still doing protocal. They are having symptoms like me so it seems clear they have Pyrroluria.
Posts: 905 | From Santa Cruz,Calif | Registered: Aug 2005
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First morning void or 24-hour urine collection Chromatography uniquely separates three precoproporphyrins and coproporphyrins I and III Pre coproporphyrins reported separately and total precoproporphyrins expressed per uroporphyrins
Urinary porphyrins are oxidized intermediate metabolites of heme biosynthesis and have been associated with genetic disorders, metabolic disturbances/diseases, poor nutritional status, oxidative stress, and high level exposure to toxic chemicals or metals. Specific urine porphyrin profiles are associated with high level exposure to mercury, arsenic, lead and some toxic chemicals. Precoproporphyrins are reported separately and per unit uroporphyrin to increase detection even when heme production is very low.
Urinary porphyrins are oxidized intermediate metabolites of heme biosynthesis and are readily excreted in excess when porphyrinogens accumulate as a result of inhibition of specific enzymes in the heme biosynthetic pathway. Heme is required for oxygen binding, transport and utilization, cytochromes, and electron transport in mitrochondira. The high rate of production of heme facilitates the use of urinary porphyrins as early and sensitive biomarkers of disorders in heme production, and has long been associated with genetic disorders, metabolic disturbances/diseases, nutritional status, oxidative stress, and high level exposure to toxic chemicals or metals.
Specific urinary porphyrin profiles have been associated with very high levels of toxic metals such as mercury (Hg), lead and arsenic. Mercury specifically inhibits two enzymes in porphyrinogen metabolism: uroporphyrinogen decarboxylase and coproporphyrinogen oxidase (CPOX). Inhibition of those two enzymes, particularly in the renal cortex, results in accumulation of pentacarboxyporphyrinogen and coproporphyrinogen III. Oxidation of the abnormally elevated porphyrinogens results in elevated urinary levels of total porphyrins, pentacarboxyporphyrin and coproporphyrin III. Recent research has identified an additional abnormal porphyrin in the urine of Hg-exposed dentists and also in rats fed very high levels of mercury for extended periods of time. A third Hg-associated porphyrin is most commonly referred to as ``precoproporphyrin'' as it elutes after pentacarboxyporphyrin and before coproporphyrin I. The recently described precoproporphyrin has yet to be characterized with respect to molecular identity and appears to be elevated in Hg exposed individuals who carry a variant of the CPOX gene (CPOX4 polymorphism). Research at Doctor's Data, Inc. has identified three separate precoproporphyrin peaks. Since knowledge about the Hg-associated precoproporphyrin entities is limited, we report the levels of all three peaks separately, as well as the total, for research use. Since uroporphyrin levels are not known to be affected by Hg, we also report the total precoproporphyrins-to-uroporphyrin ratio to increase the sensitivity for detecting abnormalities in individuals with low heme biosynthesis as may occur in children with nutritional deficiencies and/or autism.
Arsenic exposure has been associated with elevated levels of uroporphyrins and coproporphyrin I, and an elevated ratio of coproporphyrins (I: III). Lead exposure has been associated with elevated levels of coproporphyrin III.
Exposure to hexachlorobenzene and dioxin has been associated with elevated levels of uroporphyrins. Exposure to polyvinylchloride (PVC) and polybrominated biphenyl has been associated with elevated levels of coproporphyrins.
Various drugs and other substances can suppress enzymes involved in porphyrin metabolism and affect the levels of urinary porphyrins. Such compounds include alcohol, sedatives, analgesics, antibiotics, estrogens, and oral contraceptives. Anemia, pregnancy, and liver disease can also affect porphyrin metabolism.
The Urine Porphyrins test is best used in conjunction with urine toxic metals pre- and post-provocation testing.
Posts: 861 | From USA | Registered: Dec 2008
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posted
My Bio labs test was paid for by medicare. I never did see a bill so not sure how much. A good book that talks about Pyroluria Is Depression free naturally by Joan Mathews Larson She also talks about Bio labs 1-800-494-7785 Good explanation of what the supps do
Posts: 905 | From Santa Cruz,Calif | Registered: Aug 2005
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posted
If Bio-Lab is considered one of the best then I guess it's worth the money. If I went to LabCorp I would probably be wondering if it was done the right way.
Thanks for the info.
brooke
Posts: 117 | From PA | Registered: Aug 2008
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