posted
Mepron and Malarone helped my babesia symptoms a lot, but they also tore up my entire GI tract.
Took 1/4 pill of Larium (mefloquine) on Wed. and have been jittery/out of it for the past 3 days.
Called my doc, who said we'll try something else.
What are my other options?
I'm presently taking 500mg Zithromax, 300mg Omnicef, and artemisinin (along with various herbs for inflammation, antifungal, probiotics, etc.)
Posts: 330 | From TN | Registered: Sep 2011
| IP: Logged |
lymeladyinNY
Frequent Contributor (1K+ posts)
Member # 10235
posted
Please, this is only a guess and should be discussed with your doctor, but I think a drug called pyromethanine helps with babesia. After I post here I will look it up, okay?
-------------------- I want to be free Posts: 1170 | From Endicott, NY | Registered: Sep 2006
| IP: Logged |
lymeladyinNY
Frequent Contributor (1K+ posts)
Member # 10235
posted
I looked it up - it's called pyrimethamine and is used with folic acid. It has been used in third world countries for malaria treatment to the extent that it has some resistance. Still, it's worth a question to your doctor. Good luck!
-------------------- I want to be free Posts: 1170 | From Endicott, NY | Registered: Sep 2006
| IP: Logged |
I'm already taking artemisinin and zith; I guess my doc wants to add an antimalarial specifically for extra "oomph" :-)
Posts: 330 | From TN | Registered: Sep 2011
| IP: Logged |
Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Consider artemisinin and berberine.
(Berberine Chloride is likely the best form.)
Malaria:
"These results indicate that berberine is more effective in clearing the parasite than both tetracycline and cotrimoxazole, and that
the combination of pyrimethamine and berberine gives the best results for chloroquine resistant malaria."
PMID: 9337003
I keep trying hard to tell you all...berberine chloride is AMAZING and has MANY MANY benefits!
Go here and see mention of that combo(artemisinin-berberine herbal mixture after meals):
And I have lots of other links as well as to its remarkable MULTIPLE modes of action.
The presence of 20 carbons in berberine chloride looks to be very very very important.
Berberine chloride is this: C20H18NO4.Cl.
The diterpenes, which are C20 terpenes, include retinal (the essential light-absorbing pigment in rhodopsin, the photoreceptor protein of the eye), phytol (a constituent of chlorophyll), and the gibberellins (potent plant hormones).
Phosphatidylglycerol is often the main component of some bacterial membranes.
It has important functions in lung surfactant, where its physical properties are significant, and in plant chloroplasts,
where it appears to have an essential role in
photosynthesis.
Also, it is the biosynthetic precursor of cardiolipin.
In some bacterial species, the 3'-hydroxyl of the phosphatidylglycerol moiety is linked to an amino acid (lysine, ornithine or alanine) to form an O-aminoacylphosphatidylglycerol or complex 'lipoamino acid'.
Cardiolipin is a unique phospholipid with in essence a dimeric structure, having four acyl groups and potentially carrying two negative charges (and is thus an acidic lipid).
***It is an important constituent of mitochondrial lipids especially,***
so heart muscle is a rich source. Amongst other functions, it plays a key role in modifying the activities of the enzymes concerned with oxidative phosphorylation.
So if Bb is "stealing" the precursor to OUR cardiolipin = mitochondrial dysfunction (because it is a constituent of mitochondrial lipids)?
Berberine is cardiac protective and it is capable of mitochondria biogenesis (the creation of more mitochondria).
Restore the balance...help out the mitochondria in the Bb infected defense cells so they can finish their job!
[ 06-16-2012, 05:36 PM: Message edited by: Marnie ]
Posts: 9426 | From Sunshine State | Registered: Mar 2001
| IP: Logged |
posted
Then clindamycin might be a good choice. With quinine, as Tutu said. Can be taken orally, or IV for that extra "oomph!"
Posts: 962 | From Charleston | Registered: Jan 2002
| IP: Logged |
'Kete-tracker
Frequent Contributor (1K+ posts)
Member # 17189
posted
The standard treatment... before they came up with that $$$ "yellow paint" (Mepron) that one choked down & took with those pretty red caplets? ("Zith") was: clindamycin (e.g: "Cleocin") plus quinine (e.g: "Qualaquin").
Not quite as effective, BUT cheaper [relatively], and is the 2nd choice as recommended by the IDSA for treatment of "babs".
The main issue with this older combo is the possible intolerance to quinine. Some folks are sensitive to it (it has a bitter taste) & *might* experience systemic problems, possibly serious.
From a legal website: "Quinine has been shown to cause cardiac arrhythmias, thrombocytopenia (a decrease in blood platelets that can cause hemorrhage or clotting problems) and severe hypersensitivity reactions."
SO, you should go over this with your doctor's office so they can monitor you for any allergic reaction to quinine, & also review the other drugs you are on as it can inter-react with some.
Posts: 1233 | From Dover, NH | Registered: Sep 2008
| IP: Logged |
-------------------- old joke: idiopathic means the patient is pathological and the the doctor is an idiot Posts: 4676 | From western Montana | Registered: Apr 2009
| IP: Logged |
posted
Just took coartem. It seemed to really help, moreso than all the others I have taken: clindamycin/zith/mepron, malarone, daraprim, artemisinin.
Posts: 618 | From NC | Registered: Oct 2009
| IP: Logged |
Sammi
Frequent Contributor (1K+ posts)
Member # 110
posted
Just be aware that Quinine can have some nasty side effects. My doctor does not prescribe it because of this.
Posts: 4681 | Registered: Oct 2000
| IP: Logged |
posted
Usually by itself, with meds break 3-4 days before and after. I have seen others post some continue some meds but be sure to check ALL other medications as you can take nothing else (e.g., zith, bactrim) that may prolong the Q-T interval.
Posts: 520 | From Maryland | Registered: Jan 2007
| IP: Logged |
The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:
The
Lyme Disease Network of New Jersey 907 Pebble Creek Court,
Pennington,
NJ08534USA http://www.lymenet.org/
UBBFriend: Email this page to someone!
Printer-friendly view of this topic