posted
My daughter Z has had a deep ache in her legs that is constant. It can get worse when exercising! This happened after taking Doxycycline for 4months. She is off of Doxy but still in pain! Magnesium doesn't seem to make a difference. I think Doxy increased her cysts:( D
Posts: 17 | From Michigan | Registered: Feb 2015
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Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
I feel like Forrest Gump and his buddy- there are a lot of ways to cook shrimp....
Babesia kills the red blood cells that carry oxygen, etc. to tissues/muscles. Without enough oxygen. minerals, etc. the muscles will hurt.
Lactic acid can burn in the muscles and cause cramping in the also.
Sometimes those who get no relief with magnesium find relief with calcium. If used, do it at night mostly as it can make one drowsy.
Blood should be tested for "thickness". If too thick, muscles will ache. Heparin therapy might be of help if that is the cause.
Might suggest a few calcium pills with a chaser of gator aid to be sure potassium and electro-lites are balanced. Eat bananas, potatoes and other foods rich in potassium.
Do NOT push exercises until this condition has improved. Shin splints can suddenly appear and be very miserable; and it takes several weeks- sometimes more- to recover from shin splints.
BoxerMom
Frequent Contributor (1K+ posts)
Member # 25251
posted
This was a Babesia symptom for my husband and me. I know she just had to stop Malarone. This symptom will probably continue until she's had several months of consistent Babesia treatment, but it does go away.
Mine was especially bad in my quads/thigh muscles.
posted
Have you tried a magnesiu oil or spray? Maybe she's not absorbing the magnesium.
How are her other mineral levels? Vitamin D?
-------------------- sixgoofykids.blogspot.com Posts: 13449 | From Ohio | Registered: Feb 2007
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
PQQ.
Our mitochondria (powerhouses of the cells) make a LOT of ATP via a process called oxidative phosphorylation which drives Mg back into the cells. Mg is an anti-histamine, anti-inflammatory and is a HMG Co-A reductase inhibitor (like a statin). Mg binds to ATP as Mg-ATP.
PQQ is available OTC and is safe. It is in a lot of foods (and IN ...get this... the universe!).
PQQ ***Triggers mitochondrial biogenesis*** for starters = make more powerhouses -> more ATP driving Mg back in.
Along with ubiquinOL should help. Note the "OL" at the end.
That is the *antioxidant form* of CoQ10. Life Extension brand is good.
Mitochondrial dysfunction happens in a LOT of diseases.
The mitochondria are the powerhouses of our cells. There are many in each cell, but they can (and do) suffer damage from ROS - "free radicals"/reactive oxygen species.
Mitochondria have their own DNA which (usually) comes just from mom - I found one exception on the internet. Our "other" DNA comes from both of our parents and it is housed in the cells' nucleus.
Apoptosis = cell death. We do need INFECTED cells to die along with whatever nasty pathogen is inside them (including viral protein particles, bacteria, fungus, etc.)
P5P (the active form of B6) by NOW (Brand name) may also help the mitochondria because that brand also contains B2 (riboflavin) and Mg and Ca which all work - together. The riboflavin is needed by our mitochondria in complex 2 and (I think complex 3) to make FAD and FMN.
Bb can't make riboflavin (B2), but it has a transporter...
B6 works with an enzyme called CBS -> cysteine -> taurine (LOWERS CHOLESTEROL) + GSH (glutathione) + sulfate to lower homocysteine via a process called transsulfuration.
Bb can and does make homocysteine (so do we when we eat protein which we NEED) which triggers HMG CoA reductase (statin drugs to lower cholesterol INHIBIT HMG CoA reductase).
We need to make cholesterol. It is used to make MANY things!
Homocysteine can also be lowered via a "recycle" pathway called remethylation. That pathway requires B9 (folate/folic acid), B12 and zinc and several enzymes that somewhere along their pathway to be made needed Mg. Persons who genetically can't process B9 (folate) or B12 (+ intrinsic factor) ***to their useful forms*** have a problem lowering homocysteine via the "recycle" pathway. Protein -> methionine -> SAM (as in SAMe for depression) -> SAH -> homocysteine. OR the transsulfuration pathway.
Both pathways are supposed to be working if we are healthy and don't have genetic problems interfering with those pathways.
All of this is happening at incredible speed.
Consider: Gigartina (red algae)- read about it.
Also look very closely at a product called MEMREE PLUS. The doses of PA and PS are VERY SPECIFIC! We can't get it yet, but there are substitutes available. This maybe esp. helpful for those with "neuro" problems.
In lyme and in other diseases, the "HPA" axis is thrown off. Normally phosphatidylserine helps to rebalance the axis. The hypothalamus, pituitary and adrenal glands sort of "talk to" / signal one another. Women's cortisol stays higher longer...it takes us (I am female) a longer time to "cool down"...we have to talk it out...
DHA-PA has the highest binding to rhodopsin. DHA is one of the Omega 3's and it is *structural* and is a component of our cell membranes. EPA, the other omega 3 is functional = anti-inflammatory.
PA in the cytosol triggers the IMPORT of a cell transcription protein called FoxK1 into the cell nucleus.
CRM-1 is involved with the export.
In a second, I will talk more about CRM-1.
Nuclear import and export of Foxk1 is mTOR and CRM1-dependent, *respectively*. PA activates mTOR.
"The lipid messenger phosphatidic acid (PA) plays a critical role in the stimulation of mTOR signaling."
Bb uses/robs us of a LOT of OUR nutrients = cellular "starvation". There is a lot of cross-talk between the cells' nucleus and the mitochondria (also in the cytoplasm of the cells).
***Assuming her Doxy was given soon enough and for long enough, it USUALLY is successful at destroying Bb and company. However, the *recovery* may take a little longer as this pathogen does a number on our mitochondria et al.
So your daughter is likely now in the recovery and rebuilding stage which we can speed along with the nutrients mentioned i.e., PQQ, UbiquinOL, P5P - especially.***
RESEACHERS really deeply into this might want to keep reading...
others, this is going to get really complex - warning.
I think the WFL has a LOT of rhodopsin and captures a lot of available light during the night as it hunts for insects to eat...
It is also possible that the cyan blue (turquoise colored) belly which likely contains cyanophores plays a part. The color we see means the light in that wavelength is NOT be absorbed, but is reflected. All the other wavelengths are being absorbed. Every element has a wavelength and cyan (NOT absorbed, but reflected) corresponds to "Carbon 6").
Light activates Rac 1 (= a small GTPase / RAS-related C3 botulinum toxin substrate 1) and it ***co-precipitates with RHODOPSIN*** on Con A Sepharose.
Likely Bb wouldn't like that to happen.
OspC hides the fact that the C3 toxin component is in the outer surface proteins: OspA and OspB.
And OspC binding to p8 (which looks to be a protein within HTLV-1) as well as SALP15, both prevent our T cells from working properly and communicating with each other...buying time for Bb to infect before OspC -> OspA and OspB.
p8 inhibits mannose binding lectin...we know.
Mannan-binding lectin *activates C3* and the alternative complement pathway.
C3 convertases bound to the surface of B. burgdorferi s.l. can induce amplification of the alternative pathway by
*enhancing C3 activation, which could be
detrimental for Borrelia survival*
Rac1 and rhodopsin are not just proteins in our eyes. Very recently they have been found in our skin cells! Light users...take note.
I am concerned that in lyme a similar thing is happening that happens here:
Can you see from the above if someone was misdiagnosed with RA and not lyme (too few "bands" showed up) and was given steroids prior to doxy, might trigger the M2 response -> "autoimmune".
My sis.
How did I find all of this?
My son very likely has fragile X and ***activation of Rac 1 and its effector p-21 activated kinase (PAK)***
is impaired at hippocampal synapses in the FRM-1 knock out the mouse model for fragile X.
Silencing Rac1 (a GTPase)inhibits hormone release, prevents high K + evoked PLD1 activation and blocks the formation of PA at the plasma membrane.
I saw the connections...the eye doc didn't even have to instill eye drops to dilate his eyes...he already is trying to take in as much light as possible.
His cholesterol is low...too low...and we also have a friend with MS.
Lyme, HIV, MS, Fragile X all have a major problem with the tryptophan pathway.
My son's 1st seizure happened at puberty (homocysteine goes up in boys esp.)and he had "spikes" in his occipital region.
The occipital lobe is at the back of our head. It controls our visual function, regulates our rest,
and ***synchronizes ALL the cerebral lobes!!!*** It produces
delta brain waves and the neurotransmitter serotonin.
The easiest way to explain fragile X (and my son has the ADHD component, learning disabilities, seizures and autism symptoms) is to say that in the "X" part of his chromosome, there are a lot of CGG repeats interrupted with AGG. Think of CGG as a fence line and AGG are the fence posts. He is missing some fence posts and the CGG repeat goes on and on. In order to silence it, it is hypermethylated.
Color blindness is also in the X region...
To the best of my ability.
Posts: 9426 | From Sunshine State | Registered: Mar 2001
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posted
Dont forget that heavy metals are sometimes released in circulation during treatment. Heavy metals compete with your good minerals (such as zink, iron, magnesium, etc.) on binding sites.
So if you are going to make sure she gets all the "good" minerals, then also make sure these minerals dont get blocked by heavy metals. Some people just cant get rid of heavy metals easily and then these metals end up circulating in the blood and entering the cells.
Posts: 381 | From The Netherlands | Registered: Nov 2013
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posted
Definitely up the magnesium and keep it up. Most drugs deplete magnesium so it is a constant battle.
Magnesium oil is a good thing to add .. and maybe nightly epsom salt baths as well.
-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 96223 | From Texas | Registered: Feb 2001
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droid1226
Frequent Contributor (1K+ posts)
Member # 34930
posted
This has been a major issue for me.
Probably one of a few things.
Low Magnesium
Low Potassium
Leg/back nerve issues, this can affect the legs without having back pain but the root cause could still be in the back.
Toxicity, this is a major one for me. I noticed that my legs get very weak/painful until I do a coffee enema. Take from that what you will. This would be in the same arena as coagulation, MTHFR.
Bartonella, ehrlichiosis, babesia, lyme.
It's probably a combo of a few of these maybe with some I didn't list.
Vitamin D was mentioned...That's entirely possible.
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