" risk of renal impairment when aspirin (in doses over 300 mg daily) given
>with angiotensin-II receptor antagonists , also hypotensive effect antagonised."
>
>http://bnf.org/bnf/bnf/current/doc/41001i361.htm

Yes, most sources say no drug interactions. But...this is an off label use, a new drug, at higher doses than intended and it does impact the kidneys and liver (where all drugs are "detoxed").

I don't claim to understand the highly complex immune system, but starting at the beginning (with the pathogen):

(1)"Some bacteria such as Neisseria gonorrhoeae, Neisseria meningitidis, and Hemophilus influenzaea, however, have receptors for human lactoferrin and transferrin and can utilize iron bound to these compounds.

Borrelia bergdorferi is a bacterium that doesn't even use iron as a cofactor for enzyme reactions. It instead uses magnesium."

Doc Kaiser's Microbiology Home Page
Copyright � Gary E. Kaiser

(2)E. Required by immunological process. Magnesium, immunity, and allergy: Mg is required for several steps of immunological reactions
1. Lymphoblastic transformation, a prerequisite of secretion of antibodies by lymphoblasts, requires Ca2+ and Mg2+
2. Mg is required for synthesis of proteins, immunoglobulins included
3. Antibody-induced complement activation is Mg dependent
4. The antigen-immunoglobulin-complement reaction induces degranulation of the mastocyte
http://www.mdschoice.com/elements/elements/major_minerals/magnesium.htm

and finally this "relationship":

(3)"CONCLUSIONS: These data demonstrate a relationship between angiotensin II and intracellular magnesium and calcium. In hypertension, angiotensin II-stimulated calcium responses may be related to simultaneously decreased intracellular magnesium concentrations."

PMID: 8390527

Re: kidneys:

"dependent on angiotensin II to maintain filtration pressure"
http://www.medicineclinic.org/AmbulatorySyllabus4/NEW%20HTN%202.htm

Thanks for supplying the reference.

I don't see Benicar mentioned anywhere there. It's talking about Angiotensin Receptor Blockers in general. It's already been stated quite a few times that Benicar works differently than the other Angiotensin Receptor Blockers, in that it protects the kidneys. The kidney thing is not an issue with Benicar, the way it is with the other ARBs.

Okay for the sake of argument, let's say magnesium's the answer. How do you propose that we correct the magnesium deficiency, and why do you suppose we have it in the first place?

I've done regular i.v. magnesium infusions, I've loaded up on leafy green veggies, I've supplemented with large doses of magnesium for months, all different types to see if one works better than another, I've done the super green drinks on a daily basis. I've increased my magnesium in just about every possible way imaginable, and the noticeable effects have been minimal. Less muscle spasming. That's about it. I was a believer in magnesium, too, still think it's a marvelous mineral, but it just hasn't been the cure-all you seem to think it is.

Has it worked for you? If so, how?

(She's referring to a Mg deficiency.)

Re-read the microbiologist's explanation.

And...don't forget...we are using Mg to make antibodies to fight it too (besides using it to make ATP, control over 350 enzymes, etc.)

Re: amt. of Mg needed. If my math is correct and if the Romanian abstract is any indication, the % drop of Mg is astounding.I knew it was low. I had no idea it was THAT LOW.

To restore those levels and MAINTAIN them until one tests negative for Bb, would require a LOT of Mg...far more than an occasional IV dose, and far more than anyone could handle orally.

The way this is working, I believe, involves the amt. of hydrogen being produced...because hydrogen inactivates PFK..an enzyme that Bb is dependent on. This helps to shut down the glycolysis pathway...using sugar, not oxygen for energy. The glycolysis route is not healthy. We only make 2 "bursts" of ATP going that route, 36 ATP if we follow the other route which is called oxidative phosphorolation.

Finally, Penny, I do not have lyme, my sister in Wisconsin (in the group of states with the greatest #s) does. She was misdx'd and given steroids. Wham...zoomed to stage 3. My research has been done to help her and others.

How did the docs/researchers know they only had 2 years to live?

I know of only one person who can accurately predict a time of death.