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» LymeNet Flash » Questions and Discussion » Medical Questions » Peroxinitrate

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Author Topic: Peroxinitrate
Marnie
Frequent Contributor (5K+ posts)
Member # 773

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"Natural vitamin E formula that features: d-alpha tocopherol combined with a mixed tocopherol blend, achieving a one-to-one ratio of alpha to ***gamma-tocopherols***..."

"Provides gamma-tocopherol for unique protection against peroxinitrate; a highly reactive free radical."

http://www.tissuerecovery.com/supplements.shtml

Immunochemical techniques have been
developed for the detection of nitrated tyrosine residues, the

indicator of peroxinitrate-induced protein damage

http://www.bentham.org/cnr/sample/cnr2-1/008AG.pdf.


It looks like the "gamma tocopherol" in Vitamin E is especially important and it maybe impacted by the amt. of "alpha trocpherol" (more abundant).

There's a difference:

Alpha-tocopherol differs from gamma-tocopherol by the presence of a methyl group in the 5 position of the chromanol ring. Gamma-tocopherol lacks this methyl group.

Corn oil and soybean oil contain the most of this naturally.

Looks like Bb maybe using OUR tyrosine for its own advantage and we meanwhile, are also using it to fight.

Tyrosine, an amino acid, is involved in glycolysis, CoQ10 formation, and dopamine -> norepinephrine -> epinephrine.

We look to not have enough to "go around". Too many deficiencies triggering NFkB ACTIVATION.

[ 15. December 2006, 08:58 AM: Message edited by: Marnie ]

Posts: 9426 | From Sunshine State | Registered: Mar 2001  |  IP: Logged | Report this post to a Moderator
nan
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THANK YOU, Marnie!

My Nature Made lists alpha d-tocopherol and mixed tocopherols...no strengths mentioned as on the tissue recovery site.

And I thought Vitamin E was just vitamin E!!??

[Big Grin]

--------------------
nan

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Marnie
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Results: The concentrations of alpha and gamma tocopherols in CSF correlated significantly with their respective concentrations in serum. This would be expected since these nutrients have to be supplied by diet to serum followed by transport to the brain. The ratios of alpha to gamma tocopherols in the CSF and serum were highly correlated. High concentrations of alpha in serum tended to suppress gamma in both serum and CSF.

Conclusions: These data suggest that the processes involved in the entry of tocopherol from blood to the CSF do not discriminate between the alpha and gamma tocopherols.

In contrast, alpha tocopherol is highly preferred during the packaging of plasma lipoproteins by the liver.

Our data also suggest that alpha and gamma tocopherols will be available to the human brain via transport from blood.

Journal of the American College of Nutrition, Vol. 23, No. 3, 233-238 (2004)


Technical Abstract: Some nuts and seeds are among the highest natural sources of vitamin E in the US food supply.

In its chief function as an antioxidant, vitamin E prevents free radical reactions, which is important in the protection of cells from oxidative damage.

Vitamin E has been associated with reduced risk of certain cancers such as colon, bladder, and prostate.

Recent studies have focused on effects of gamma-tocopherol as well as alpha-tocopherol.

While there are eight forms of vitamin E, alpha-tocopherol is the only form currently used to estimate the Dietary Reference Intake (DRI) for vitamin E.

The other forms are absorbed and may have other functions, but are not converted to alpha-tocopherol in the body.

The Recommended Dietary Allowance (RDA) for alpha-tocopherol is 15 mg/day for adults.

According to NHANES 2001-2002, more than 90% of adults do not meet the Estimated Average Requirement of 12 mg/day.

Nuts and seeds are often cited as good sources of vitamin E. USDA has recently updated tocopherol values in several nuts and seeds in the USDA National Nutrient Database for Standard Reference (SR).

Findings indicate 1 oz. portions of almonds, hazelnuts, and sunflower seeds provide greater than 20% of the RDA for vitamin E; and brazilnuts and pine nuts provide between 10 and 20% of the RDA.

One-ounce portions of cashews, macadamias, pecans, pistachios, black and English walnuts, flaxseed, and sesame seeds all provide between 1 and 4% of the RDA.

***The highest nut and seed sources of gamma-tocopherol are black walnuts (28 mg/100g), pecans (24 mg/100g), pistachios (22 mg/100g), and English walnuts and flaxseed (20 mg/100g).***

These tocopherol values are derived from data from USDA studies, as well as the food industry and the scientific literature. Keeping SR up-to-date allows researchers to more accurately estimate nutrient intake, thus enabling them to more effectively study the relationships between diet and disease.

Last Modified: 10/01/2006

http://www.ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=196269

PERSONALLY...I likely would start sprinkling sesame seeds on a lot of my foods. And my choice of WHICH Omega 3 might be from Flaxseed (kill 2 birds with one stone!).

Ahhh...as the Bible tells us...return to the seeds and nuts, the fruits and vegetables...

Beginning to make more and more sense.

One possible source for higher gamma tocopherols(reliable? No watchdogs to make sure...):

http://www.yasoo.com/vite-maxi-overture.htm?gclid=CIGJ9anUlIkCFQpNUAoda3T25w

I'm sure there are others "out there".

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