Dawn in VA
Frequent Contributor (1K+ posts)
Member # 9693
posted
did a search on pubmed and nothing new seemed to be up there. any info that you know of that has not yet been published?
-Dawn
-------------------- (The ole disclaimer: I'm not a doctor.) Posts: 1349 | From VA | Registered: Jul 2006
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
No update on lizard...or glycine...
Personally, I'm in the middle of a home move...tons to do (!), but trying to squeeze in PKC delta research since it *looks like* Bb has a PKC -delta- INHIBITOR...which is impacting our defensive cells from the get-go.
"Protein kinase C-delta (PKC-) is involved in growth, differentiation, tumor suppression and regulation of other cellular processes. PKC- activation causes translocation, tyrosine phosphorylation(TyrP) and serine-threonine kinase activity."
Protein kinase C delta is essential to maintain CIITA gene expression in B cells.
Expression of MHC class II genes requires CIITA
MHC Class II molecules are found only on a few specialized cell types, including macrophages, dendritic cells and B cells, all of which are
professional antigen-presenting cells (APCs)."
Looks like Bb prevents our macrophages (come from monocytes stored in fat), dendritic (langerhans) and B cells from their antigen (proteins) presenting ability...
Fibroblasts or esinophils to the rescue...to a degree?
***DAG looks to activate PKC delta.***
aspartate-alanine-glycine = (DAG)= diaglycerol
"The accumulation of DAG also increases the Ca(2+)-independent PKC activity, thus resulting in the potentiation of the Gly (glycine) response in the SDCN neurones."
Weird...
"Diacylglycerol (DAG) and one synthetic DAG (1- oleoyl-2-acetyl-sn-glycerol:OAG) have been demonstrated to cause increase in melanin content of cultured human melanocytes without the need of UV light exposure.
Topical DAG induces a long-lasting increase in epidermal pigmentation, presumably through protein kinase C activation. DAG may thus play a role in skin tanning in the future, as exposure to harmful UV light is not necessary."
"PKC-delta deficient mice and autoimmune disease" And...
"The PKC-delta- dependent activation of mitochondrial K-ATP channel opening might be synergistic with its direct effect, making nicorandil an efficient opener of such channels."
PMID: 15175555
Go here too (!)re: beta pancreatic cells (insulin producing) and PKC delta:
Much to read and evaluate (safe/not safe), but looks like a major key.
Insulin ACTIVATES PFK (enzyme...phosphofructrokinase) which we know Bb is dependent on and likely is decreasing too.
Finally...
"DAG activates ***Mg influx*** by way of protein kinase C (pK C) activity"
You didn't really think I wouldn't mention Mg, did you? ;-)
Posts: 9426 | From Sunshine State | Registered: Mar 2001
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CaliforniaLyme
Frequent Contributor (5K+ posts)
Member # 7136
posted
Nice to know you are still around Marnie!! Good luck with the move!
-------------------- There is no wealth but life. -John Ruskin
All truth goes through 3 stages: first it is ridiculed: then it is violently opposed: finally it is accepted as self evident. - Schopenhauer Posts: 5639 | From Aptos CA USA | Registered: Apr 2005
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Geneal
Frequent Contributor (5K+ posts)
Member # 10375
posted
You know Ms. Marnie,
I was just saying to Ms. Lymetoo that you hadn't posted in quite some time.
Glad to see you are still around and kicking!
Hugs,
Geneal
Posts: 6250 | From Louisiana | Registered: Oct 2006
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Dawn in VA
Frequent Contributor (1K+ posts)
Member # 9693
posted
Thanks for your reply, Marnie, esp. with your moving and all! Hope it goes smoothly and you love your new place.
I'm always very grateful for the research-oriented subjects and insights you post. I fear I was way sleepy in my 8AM biochem classes, but do remember bits and pieces when my brain decides to turn on.
I hope some researchers are focusing on the FlaA and FlaB proteins, seeing as how band 41 is the most "common" (so it's been said, anyway) one found in lymies. I think if we could figure out a way to cleave the N and/or C terminals of Bb's insanely well-protected, jelly-coated flagella...
Oooo, I'd like to stick a crowbar in that corkscrew.
-------------------- (The ole disclaimer: I'm not a doctor.) Posts: 1349 | From VA | Registered: Jul 2006
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