posted
Anyone have tonsil/adenoid enlargement from lyme?
My 3 year old son who breastfed while I was dx with lyme and babs has HUGE tonsils and adenoid gland.
His ENT originally said don't treat (that was last year and before my dx).
Now his quality of life is declining from serious lack of sleep. He has MAJOR apneas (resulting in a pulse ox drop to the 70s!).
He has a visit to Dr. J scheduled for Sept. The ENT doesn't think it's lyme related, but isn't sure.
He says even if it is induced by lyme, these tissues take so long to reduce after infection and will reinflame at every cold, it may be worth a tonsilectomy/adenoidectomy.
Posts: 524 | From Hudson Valley, NY | Registered: Jul 2007
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posted
My younger sister had her adnoids and tonsils removed when she was very young.
Now her daughter had her adnoids and tonsils removed last week. She was constantly conjested and was having problems sleeping as well. Now they are looking at possibly taking her sons out also.
It is not a Lyme related issue for any of them. And from what I understand it is fairly common for children to have adnoid and tonsil issues.
So, it may be the lyme causing it or it may just be a normal child hood issue and lyme which may be compounding the problem.
Proud
-------------------- PROUD : )
Dx: Lyme & Bart April 2008. currently on plaquanil, Roxid and Sulfameth. Posts: 89 | From Manalapan, NJ | Registered: Feb 2008
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posted
Both my children (who have lyme) had major problems with their adeniods. My daughter also had chronic tonsilitis. Both had surgery to remove their adenoids and my daughter her tonsils. This was prior their diagnosis, but I strongly believe it was relate to their congential lyme.
My daughter's adenoids were so large, she like your son slept very poorly. She snored like a trucker. It was amazing how well rested she was once she had the surgery.
Also something else to mention. I went to a talk by a ENT who talked about snoring and mouth breathing in children. It can actually change the shape of the childs facial structure, as we are built to breath through out noses not our mouths, so if a child mouth breaths the facial structure changes to make a larger airway. I would discuss this with your ENT.
Posts: 41 | From Singapore | Registered: Jan 2008
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Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
There was a study done... ok.. I'll see if I can find it...
Hold on...
Well, I can't find it. Looked a good while too. Sorry.
But the info said something to the effect... and I may have some of the details wrong.. but... guessing here on numbers.
Duray (I believe) checked 12-20 (?) tonsils that were discarded after surgery... and found spirochtes in them.
This isn't the study... but it does show that spirochetes IN tonsils can survive AND replicate.
Hope this helps.
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J Infect Dis. 2005 May 15;191(10):1747-54. Epub 2005 Apr 6.
Invasion of human tissue ex vivo by Borrelia burgdorferi.
Duray PH, Yin SR, Ito Y, Bezrukov L, Cox C, Cho MS, Fitzgerald W, Dorward D, Zimmerberg J, Margolis L. Collaborators (1)
Department of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. [email protected]
Borrelia burgdorferi sensu stricto is an etiological agent of Lyme disease. The lack of an adequate ex vivo system for human tissue infection is an obstacle to fully understanding the molecular mechanisms of invasion of tissue by B. burgdorferi and its adaptation within the human host.
Here, we report on the development of such a system. We inoculated blocks of human tonsillar tissue with B. burgdorferi spirochetes, cultured them in a low-shear rotating wall vessel (RWV) bioreactor, and analyzed them using light and electron microscopy, nested polymerase chain reaction (PCR), and quantitative real-time PCR.
Also, we evaluated the expression of the outer surface proteins (Osps) OspA and OspC by use of quantitative Western blotting. Light and electron microscopic analysis revealed multiple spirochetes localized extracellularly within the tissue, and their identity was confirmed by PCR.
Quantification of spirochetes inside the RWV-cultured tonsillar tissue demonstrated that the number of B. burgdorferi exceeded the initial inoculum by an order of magnitude, indicating that spirochetes replicated in the tissue.
Electron microscopic analysis showed that some spirochetes were arranged in cystic structures and that invading spirochetes differentially expressed surface proteins; both of these features have been described for infected tissues in vivo.
The system we have developed can be used to study B. burgdorferi pathogenesis under controlled conditions ex vivo, in particular to explore the gene activation responsible for the adaptation of B. burgdorferi to human tissue that leads to Lyme disease.
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