Lopes de Carvalho I, Fonseca JE, Marques JG, Ullmann A, Hojgaard A, Zeidner N, N�ncio MS.
Center for Vector and Infectious Diseases Research, Instituto Nacional de Sa�de Dr. Ricardo Jorge, Lisbon, Portugal.
We report the isolation of Borrelia lusitaniae from a 13-year-old female child presenting with a vasculitis syndrome.
The patient was treated with doxycycline, 100 mg bid for 20 days, and is in remission after a follow-up of 2 years.
These results should alert clinicians to the fact that B. lusitaniae may be pathogenic in humans, highlighting that patients may be seronegative or present with minimal positive antibody titres and clinical signs that are not specific for Lyme borreliosis.
In order to prevent the occurrence of more serious disease manifestations via timely treatment, the analysis by molecular methods may be a useful approach when antibody titres are uninformative.
PMID: 18795392 [PubMed - as supplied by publisher]
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
VERY good info AG. Helps me and will help others too.
I've not heard much on this strain... so interesting.
Now...
I'm not sure a standard dose of Doxy will do the trick for me... but it is worth a try.
Is that 200 mg a day for 2-3 weeks?
Or when in Portugal, do as the Portugalians do.. and get a couple months of Doxy?
AliG
Frequent Contributor (1K+ posts)
Member # 9734
posted
Just guessing here.....
Do you think maybe 200mg to a 13 yr old female child might amount to 300-400mg for an adult depending on body weight?
I don't know how aggressive the strain is, maybe less so than B.burgdorferi or some other strains that people might be getting that don't test positive because they're NOT Bb?
I think kids at that age tend to have stronger immune systems than youngsters and mid-aged+.
What do I know?????? I think that makes some reasonable arguments for higher doses and longer treatment term. Whaddya think, did I do OK?
Hey can't they buy ABX at the corner store in Portugal? I know they can buy ABX/topical steroid ointment without a Rx, off the shelf.
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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posted
Vascultis-like syndrome occurs in other borrelia infectious strains/species too.
I have heard it said that children do better than adults in treating lyme. As a whole. There certainly have been some exceptions to that rule.
Think you may be right about the body weight, dosing issue.
In Spain it used to be possible to get abx over the counter but I have heard it has tightened up lately.
Posts: 8430 | From Not available | Registered: Oct 2000
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treepatrol
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posted
What is Vasculitis?
Vasculitis is an inflammation of the blood vessels, arteries, veins or capillaries. When such inflammation occurs, it causes changes in the walls of blood vessels, such as weakening and narrowing that can progress to the point of blood vessel blockage.
Lyme causes all of yhis depending on the infection. A remember heart block anytime you have a raging infection it has the chance of causing Vasculitis.
Fibrin buids up your body makes more cholesterol for the immune reponce so now you get inflamation in arteries and viens then cholesterol then sticky blood from the holes the Bb pokes in your vien artery walls tada Vasculitis.
Now the bad part.
Maintaining Remission Some vasculitis patients in remission are prescribed a "maintenance" dosage of prednisone, or an immunosuppressive such as Imuran or Methotrexate or one of the other commonly used immunosuppressives. They always want to use steroids I say treat the LYME abx's!! The good part.
Bactrim (TMP-SMX, Septra) or other formulations are often prescribed beyond remission to help maintain the disease in remission. From http://www.vasculitisfoundation.org/node/42
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posted
Very interesting. Tried to do some research on the pathogenicity of this species of Borrelia on humans but there isn't much info. out there. What I did find fascinating is that in a study they did with mice, when they ran the Western Blot, the mice only responded to band 41 whereas the mice infected with Bb, responded to 41, 39, etc.
Anyway, of course my mind races ahead and thinks "for those people who don't test positive for Bb, maybe instead they are infected with Bl."
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AliG
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posted
Great find Tree!!!!
quote:Bactrim (TMP-SMX, Septra) or other formulations are often prescribed beyond remission to help maintain the disease in remission. From http://www.vasculitisfoundation.org/node/42
KS posted:
quote:when they ran the Western Blot, the mice only responded to band 41 whereas the mice infected with Bb, responded to 41, 39, etc.
Anyway, of course my mind races ahead and thinks "for those people who don't test positive for Bb, maybe instead they are infected with Bl."
That's why I think this is so important for many here, it is VERY valid evidence that a person can have borreliosis and still "fail" their tests!!!
Symptomatic people with negative tests can give this to their non-LL, non-believing PCPs.
I think Treepatrol just made it even more important! Thanks Tree! I have to go read the details of treatment.
I wonder how they isolated it.
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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oxygenbabe
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I don't exactly see why it's good news that you have to prescribe Bactrim to keep from relapsing. It's not good to be on abx endlessly. There should be better research into eradicating borrelia(s), period.
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AliG
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posted
Good news is that it responds to ABX and so STEROIDS , which would pretty much CRUSH a Lymie, are not the ONLY means of Txing it.
Peolpe with Sx and vasculitis-like syndromes can use this to get ABX INSTEAD of steroids as Tx from their Drs.
Not everyone here has LLMDs (yet). It's good for those people who may have clueless doctors!
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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AliG
Frequent Contributor (1K+ posts)
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posted
YAY ME!!!!
I forwarded the study link to the Vasculitis Foundation, with a note about steroids being harmful in Borreliosis.
The Executive Director thanked me because they were unaware of this information.
I may have helped some unDxd Lymies whove been Dxd with Vasculitis!!!
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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I have to go read the details of treatment.![[confused]](graemlins/confused.gif)
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, which would pretty much CRUSH a Lymie, are not the ONLY means of Txing it.![[woohoo]](graemlins/woohoo.gif)
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