posted
This is way over my head but I read the article on "persisters" with the following extract:
The requirement of proton-motive force (PMF) for aminoglycoside uptake in exponentially growing bacteria has been studied exten- sively16. Although the complete mechanism of aminoglycoside uptake is unclear, it is known that a threshold PMF is required. We reasoned that, although metabolic stimuli do not rapidly stimulate the growth of persisters, they may promote PMF, thereby facilitating the uptake of aminoglycosides and subsequent bacterial killing.
Apparently aminoglycosides are a form of antibiotic. Second extract:
We found that NADH dehydrogenase activity was important for this phenotype because gentamicin activity against the DndhDnuoI strain was not potentiated by mannitol, fructose or pyruvate, although there was slight potentiation by glucose
So I am probably mixing apples and oranges but wonder if hyperbaric oxygen can increase (PMF) and glyconutrients might be combined with the antibiotic treatment to cause the mechanism necessary to to kill persisters in the article at
Any medical genius people out there to see if I have really jumped all over the place?
Posts: 366 | From Kalamazoo, Michigan | Registered: Jun 2008
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posted
By the way I am also trying to determine if photon therapy increase PMF, proton-motive force and could also be applicable. I did purchase the whole article.
Posts: 366 | From Kalamazoo, Michigan | Registered: Jun 2008
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