posted
Thx for posting this - yep, a study funded by a new nonprofit in the area due to so many residents getting Lymed. It's great to be able to refer to the study! What was surprising for me was their finding B miyamotoi here, which has also been found in S CA.
Other tick infection stats for the area: SF, a couple percent, since 10 known infections acquired in the city Santa Cruz and Monterey - 15-20% Marin and East Bay - 5-10% Sonoma and Napa - 15-20% Mendocino - hotspots show 40% infected nymph ticks, highest in the state
Sadly, people are reporting tick bites on trails leading out to the ocean so gotta stay from touching the long grasses.
More good research to come out of this effort!
Posts: 13117 | From San Francisco | Registered: May 2006
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Need to start an effort to help mate (and release at night) the WFL's!
Or...give persons succinate dehydrogenase BEFORE Bb forms its biofilm.
SQR (succinate dehydrogenase) catalyzes the oxidation of succinate to fumarate with the
***reduction of ubiquinone to ubiquinol.***
MitoQ starts the process. And it is perfect. Made in New Zealand. They have taken ubiquinone and attached it to a phospholipid that FUNCTIONS like phosphatidylcholine (one of Bb's lipoproteins), but is NOT.
Ubiquinol is the antioxidant.
In high doses, MitoQ acts as a pro-oxidant. In low doses it acts as an anti-oxidant.
Posts: 9430 | From Sunshine State | Registered: Mar 2001
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posted
Marnie - I think this was meant for a different post?
I do like the top line however - maybe Stanford could grow and release the blue belly lizards as a project!
Posts: 13117 | From San Francisco | Registered: May 2006
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Borrelia miyamotoi AND Bb have been found together in the ticks.
Let's look at B. Miyamotoi:
"Borrelia miyamotoi, a spirochete that is genetically related to the species of borrelia that cause relapsing fever, has been detected in
all tick species that are vectors of Lyme disease.
It was detected in Ixodes scapularis ticks from Connecticut
in 2001
and subsequently has been detected in all areas of the United States where Lyme disease is endemic.
...*antibody* against B. miyamotoi ***GlpQ protein***
Now we have TWO spirochetes that obtain/steal OUR choline? One of Bb's proteins is phosphatidylcholine.
Need help posting pictures.
Bob...would you once again help post a picture - the one on the right under "figures" in the link below:
First make it bigger and then find GlpQ in the upper right side and pay very close attention to L-Lactate -> pyruvate (which Bb uses for protection and/or likely Ubiquinol shuttled off as UQH2).
Bb looks to *export* succinate dehydrogenase (an enzyme, a protein).
I think the WFL overwhelmed it's export function.
"Secretion proteins.
SecA is impressive, with the highest E(g) score relative to all PHX genes of MYXXA. The gene also qualifies as PHX in most of the other δ genomes.
PHX = predicted highly expressed
The SecA gene is also PHX (predicted highly expressed) in Vibrio cholerae, E. coli, Synechocystis, Mycoplasma pneumoniae, Treponema pallidum,
Borrelia burgdorferi,
Aquifex aeolicus, and other bacteria.
The secretion pathway is used by many protein substrates.
The cellular destination of all secretory polypeptides is governed by a 20- to 30-residue amino-terminal sequence, the leader peptide, which also helps guide SecA binding to the substrate.
SecA, SecB, and SecG are all involved in
protein export and chaperone activity.
Gram-negative bacteria also secrete a variety of proteins into the extracellular and periplasmic milieu mediated by the secretion apparatus of types I to IV. These proteins can also influence bacterium–host interactions.
Succinate dehydrogenase (spit out when not needed) is an enzyme that belongs to oxioreductases which oxidize a substrate by a reduction reaction that transfers one or more hydrides (H−) to an electron receptor…in this case to FAD.
SQR executes a series of internal electron transfer reactions that
couple succinate oxidation to the reduction of ubiquinone, also known as coenzyme Q (Q):
When L-lactate -> pyruvate (pyruvate protects Bb from H2O2), UQ -> QH2 = dihydroquinone (ubiquinol).
Geeze, I wish there was ONE NAME for the same thing(s)!
Backing up a second:
There are three redox (= transfer of electrons – one thing loses electrons, another gains them) states of CoQ10:
***fully oxidized (ubiquinone)***,
semiquinone (ubisemiquinone),
and fully reduced (ubiquinol UQH2, the antioxidant).
The capacity of this molecule to exist in a completely oxidized form and a completely reduced form enables it to perform its functions in the electron transport chain, and as an antioxidant, respectively.
Very recent research indicates ***CoQ10 works WITH vitamin K2***…NOT vitamin K - K2 is a different FORM OF vitamin K which has entirely different functions (not blood clotting). Yes, vitamin K2 IS available as a supplement!
Wiki. What would I do without Wiki?!
Lyme = mitochondrial dysfunction (very common in MANY diseases!) Help out your cells powerhouses.
[ 07-21-2014, 06:36 PM: Message edited by: Marnie ]
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