LymeNet Flash: What am I doing to myself?!

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Posted by jobrien (Member # 41253) on :

I had a terrible weekend- suddenly came down with a massive toothache out of nowhere- then a frightening bout of severe sweating and fainting/vomiting feelings overwhelmed me.

Needed to start Amoxil for the tooth- could that have caused some interaction with Rocephin? Just had 3rd shot yesterday.

What other weird things happen with Rocephin? The side effects scare me more than the disease!!

Posted by David95928 (Member # 3521) on :

Jobrien,

Quite possibly you are herxing. The Rocephin is a new medication for you, right? It's pretty strong stuff. When I started treatment (Bicillin) I had a wide range of symptoms. At one point I posted the the only part of my body that didn't hurt was my hair. It did ease up as the bacterial load went down. It was worth it because I have been doing real well for over a year.

At the risk of sounding like a broken record, try drinking Detox Tea made by Yogi Tea Company. You should be able to find it at any large health food store. If your symptoms ease when you dring the tea, it is more probable that what you are experiencing is a herx. You may need to be given a smaller dose of Rocephin and build up.

David

Posted by minoucat (Member # 5175) on :

People often seem to experience severe jaw and tooth pain at some point with treatment. I've noticed that the folks on the MP board frequently mention that, as they proceed in treatment, they seem to get pain in areas where they had an old tooth infection.

The nausea and vomiting don't sound good, although they could be part of a herx. Talk to your LLMD about this; overherxing is not a good idea.

It is ALWAYS a good idea to to talk to the pharmacist about possible drug interactions. I didn't see anything specific about Amoxil, but that doesn't mean there isn't a problem there.

From RxList: http://www.rxlist.com/cgi/generic3/ceftriax_ad.htm

Rocephin is generally well tolerated. In clinical trials, the following adverse reactions, which were considered to be related to Rocephin therapy or of uncertain etiology, were observed:

Local Reactions: pain, induration and tenderness was 1% overall. Phlebitis was reported in <11% after IV administration. The incidence of injection site reaction was 17% (3/17) after IV administration of 350 mg/mL and 5% (1/20) after IM administration of 250 mg/mL.

Hypersensitivity: rash (1.7%). Less frequently reported (<1%) were pruritus, fever or chills.

Hematologic: eosinophilia (6%), thrombocytosis (5.1%) and leukopenia (2.1%). Less frequently reported (<1%) were anemia, hemolytic anemia, neutropenia, lymphopenia, thrombocytopenia and prolongation of the prothrombin time.

Gastrointestinal: diarrhea (2.7%). Less frequently reported (<1%) were nausea or vomiting, and dysgeusia. The onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment (see WARNINGS).

Hepatc: elevations of SGOT (3.1%) or SGPT (3.3%). Less frequently reported (<1%) were elevations of alkaline phosphatase and bilirubin.

Renal: elevations of the BUN (1.2%). Less frequently reported (<1%) were elevations of creatinine and the presence of casts in the urine.

Central Nervous System: headache or dizziness were reported occasionally (<1%).

Genitourinary: moniliasis or vaginitis were reported occasionally (<1%).

Miscellaneous: diaphoresis and flushing were reported occasionally (<1%).

Other rarely observed reactions (<0.1%) include leukocytosis, lymphocytosis, monocytosis, basophilia, a decrease in the colitis, flatulence, dyspepsia, palpitations and epistaxis.