I an still looking for the answer.

My doc has prescribed those two for me.

I am on Biaxin and Mino for three weeks every month...
the third week, I add in flagyl.

So, yes, they can be taken together as far as I know.

But, if you have questions...it is always best to double check with your doc or a pharmicist.

My best,
Melanie

Flagyl Oral
Minocycline Oral
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(Note: Not all drug interactions are known or reported in the literature, and new drug interactions are continually being reported. This information is provided only for your education and for you to discuss with your personal healthcare provider. )

ALCOHOL may interact with METRONIDAZOLE (in Flagyl Oral)

Metronidazole may interfere with the breakdown of alcohol. If this happens, harmful by-products from the alcohol may accumulate in the body and this may cause intolerable or otherwise undesirable side effects. Potential side effects include facial flushing, feeling lightheaded, nausea and vomiting, a rapid or pounding heart beat, and shortnesss of breath or difficulty breathing. Avoid all alcoholic beverages and alcohol-containing products (such as some cough syrups and elixirs) while you are using metronidazole tablets or suppositories. Ask your healthcare provider about these drugs and this potential interaction as soon as possible.

Yes, I have been on some sort of pulsing schedule for over a year now. It seems to work best for me- giving my body a chance to recoup in between doses.

Currently...
I take meds 5 of 7 days a week, 3 of 4 weeks a month. The forth week is abx free.

Melanie

Thanks Melanie,Tree Cleo and Joe for the responses.

I have found this in Burrascano Guidelines:

"Therefore, the trend now is to treat the chronically infected patient who has resistant disease by combining metronidazole with one or two other antibiotics to target all forms of Bb. Because there is laboratory evidence that tetracyclines may inhibit the effect of metronidazole, this class of medication may not be as useful as others in these two- and three-drug regimens. There have been some recent reports that Bb does not contain genes that would confer susceptibility to metronidazole. However, this clearly does not fit with in vitro and a large body of clinical data, which have demonstrated the usefulness of this agent in the Lyme patient. Perhaps we do not have all the genetic information needed to dismiss the use of this agent. Once again, real world experience is one step ahead of bench research. "

So I guess the mino can reduce the effect of the flagyl.............but it seems like lots of folks are doing it....... so how does one know who to believe?

robi

Still I wonder if this info has changd as it is from 2002 and LLMD's seem to prescribing this combo.

Anyone going to Dr. B that could ask him his "current opinion" on this?

robi

Dr B says in the info that you just posted that it "May Be" , but he doesn't say definitely that they are not effective if used together.

Some Dr's seem to think that they are okay together. Isn't this info from Dr B a couple of years old? I wonder if he has changed his opinion about it.

I have the brochure that came with my Tinidazole, and it says that oxytetracycline can be antagonistic if used with it, but it only lists that one, and not doxy or mino. I think that they woould have just said 'Tetracyclines" if they were all included.

i heard about the alleged mino/flagyl interaction a while back myself but after lots of investigation couldn't find a thing to sustantiate it. you can even take mepron with minocycline or minocin as the formulation is different than with tetracycline. (A no, no w/mep, reduces effectiveness by about half.)

Be careful with the flagyl.

ping said :
"don't know what dose mino(cycline or minocin?) you're on but if it's high enough (over 200mg) and you add flagyl without a titer program, you will have a dieoff so big it will put you in the hospital. "

Hope I don't end up in the hospital......my LLMD is fairly cautious so I don't think she would Rx something dangerous. Maybe she feels my load is down far enough to handle this. I have been on ABX for 11 months.

quote:

---

Originally posted by hodologica:
ping,
Can you say more about interference between tetracycline and mepron? Where'd you hear about it? Does the same apply to doxycycline?

Many thanks,
hod

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I wished I heard a success story after Mino application as I apparently tolerate this antibiotic very well; it is cheap and easy to take twice a day. I also don't have issues with yeast with this one.

I definitely feel some strange sensations while on Mino that would be consistent with cyst disintegration (sharp pains of various locations, including my head, eyes and other parts of my body that disappear quickly - seems like blood stream takes the irritating stuff away within a few seconds). I took Tini for a while before and this sensory input on Mino is very similar to what I have experienced while on Tini before.

If Mino ruptures cysts but cannot kill Bb too well, they may create new cysts in no time. Perhaps this is the problem.

More input on the issue is welcome.

I just completed 4 months of Biaxin XL 1000mg per day, Minocycline 200mg per day, and Flagyl 1000mg per day. As stated earlier...these were pulsed doses.

I'm waiting to hear back from my doc as to what will be my next step in treatment.

Melanie

What leads you to say that mino is bacterialcidal at high doses? How can taking more of a drug change it's capabilities?

"It works by interfering with the formation of essential proteins." This is from a pharmaceutical book that I have.