The good news is, it was completely worth it. I did the mepron/zith/artemesinin tx, and have been babs-free for 9 mo so far.

Below I copied the info from this website: http://www.catie.ca/supple-e.nsf/0/7b09aa55a412896c85256c6e0070bf60?OpenDocument

2. Milk thistle and other medications
Below is a short list of some other medications that are processed through the CYP3A4 enzyme. Based on the effect of milk thistle on liver enzymes in the lab, it is possible that levels of these medications may increase if taken by people who are also using milk thistle. This list is not exhaustive:

* methadone
* heart drugs - Tambocor (flecainide), Rythmol (propafenone)
* antibiotics - erythromycin, rifampin
* anti-seizure drugs - carbamazepine (Tegretol)
* antidepressants - Zyban/Wellbutrin (bupropion), Paxil (paroxetine), Prozac (fluoxetine), Luvox (fluvoxetine). Serzone (nefazodone), Zoloft (sertraline), Effexor (venlafaxine)
* St. John's wort
* antihistamines - Hismanal (astemizole), Seldane (terfenadine)
* antifungals - itraconazole (Sporanox), ketoconazole (Nizoral)
* gastrointestinal motility agents - Prepulsid (Cisapride)
* ergot drugs - Ergonovine, Ergomar (ergotamine)
* anti-psychotics - Clozaril (clozapine), Orap (pimozide)
* sedatives/sleeping pills - Ambien (zolpidem), Halcion (triazolam), Versed (midazolam)
* erectile dysfunction drugs - Viagra (sildenafil)
* street drugs - ecstasy (MDMA)
* lipid-lowering drugs (statins) - Lescol (fluvastatin), Mevacor (lovastatin), Pravachol (pravastatin), Zocor (simvastatin)
* transplant drugs - cyclosporine (Neoral, Sandimmune), ProGraf (tacrolimus)

Milk thistle also has the potential to lower levels of the following drugs in the blood:

* anti-parasite drugs - Mepron (atovaquone)
* sedatives/sleeping pills - Ativan (lorazepam)
* hormones - estrogen