If you are taking combos of antibiotics and use Tindimax (tinidazole)with diflucan (fluconazole) and/or the macrolides zithromax (azithromycin), Biaxin (clarithromycin), or erythromycin, please be aware of this Drug Interaction warning: "...tell your doctor or pharmacist of all... drugs affecting liver enzymes that remove tinidazole from your body (such as azole antifungals-including ketoconazole, macrolide antibiotics-including erythromycin, cimetidine, rifamycins-including rifabutin, St. John's Wort, certain anti-seizure medicines--including carbamazepine.)" (From a recent patient info leaflet I was given for Tindimax. I don't recall seeing this warning on earlier Rx leaflets with my hand-compounded tinidazole.)
Whether the concern is that the enzymes are affected such that the tinidazole builds up excessively or is just wasted is a question for a pharmacist--any out there to tell us?
Posted by nannie (Member # 5250) on :
up!
Posted by Health (Member # 6034) on :
Hi,
I did not take Tini, but can say that listen to what the warnings say.
I was on St Johns Wort, when I was on biaxin and flagyl, seemed to be ok, then when I switched to the zithro flagyl, my heart started to race, I did not know what it was, until one day pinpointed that it was the St Johns Wort interating with the new meds. I stopped the St Johns Wort, and no more heart racing, or throat swelling.
I then later read that there were new studies done about how St Johns Wort interacting with many medications, and not to use it if you did not have to. Made some meds less effective.
I now, often wonder if I would be much better had I not taken the St Johns wort for all the months I was on the antibiotic combos. I did not know back then, but know now.
Trish
Posted by HaplyCarlessdave (Member # 413) on :
Always pay close attention to your body's response to combinations. It's hard to know what the interactions are, and they ar probably different for different people. The abx that my doc had me stop when I started tinidazole was doxycycline; I still took clarithromycin ('biaxin').. By this time I was almost back to the land of the living, ffinally, after around 2 years of treatment. I didn't seem to have any trouble with the combination, and it's looking more and more, all the time, like the treatment did finally work. (i.e., got the cysts), since I've been off abx more than 2 years with still no relapse... (still knocking all the wood in sight...) DaveS