LymeNet Flash: 2005: minocycline and interferon-beta in a model of multiple sclerosis

This is topic 2005: minocycline and interferon-beta in a model of multiple sclerosis in forum Medical Questions at LymeNet Flash.

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Posted by CaliforniaLyme (Member # 7136) on :

1: J Neuroimmunol. 2005 Aug;165(1-2):83-91. Related Articles, Links

Effective combination of minocycline and interferon-beta in a model of multiple sclerosis.

Giuliani F, Fu SA, Metz LM, Yong VW.

Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.

The objective of the current study was to investigate whether minocycline improves the effect of an existing multiple sclerosis (MS) medication, interferon-beta, on experimental autoimmune encephalomyelitis (EAE) in mice. When used at sub-optimal doses, neither medication affected EAE but their combination at these doses led to the significant alleviation of EAE disease severity scores and histological outcomes. In culture, the toxicity of T cells to neurons was alleviated by their prior exposure to minocycline or interferon-beta and their combination further attenuated neuronal death. Collectively, these results suggest the utility of the combination of minocycline and interferon-beta in MS.

PMID: 15958276 [PubMed - indexed for MEDLINE]

Posted by Littlesprout (Member # 7406) on :

So, are you taking Mino for MS/lyme problems? That is what I have, I tried the mino last yr but the dizziness drove me crazy, can't remember the dose but I am thinking about trying it again.
It sounds like good stuff for CNS problems, maybe I will try a very low dose to start with.

I am allergic to Rocephin/Pencillin so I have been limited to what I can take.

Posted by CaliforniaLyme (Member # 7136) on :

Me- no!!! I took 9 months of IV Rocephin and got 95% and then orals brought me to 99.9% where I have stayed for 3+ years. But I had many MS/ALS symptoms and when I try to go off antibiotics my first decline is with balance- I am ultra-neuro Lyme. Scary. Sorry you are allergic to stuff!!!
Mino does have side effects for many people- it also works great but doctors tend to avoid it because of side effects-!!!
Best wishes,
Sarah in CA

Posted by lightfoot (Member # 2536) on :

Hi CA!

Thanks for posting!!

Littlesprout, when Miss lightfoot started the mino it was at very low doses and she gradually was able to get to a treating dose. Yes, it's been good for her.

Healing smiles...lightfoot [Smile]

Posted by Littlesprout (Member # 7406) on :

Thanks for the advice. I think my problem was starting to high, so will start lower this time. My husband is on it, switched from Doxy (it was rough on his stomach) He has not had any dizziness and handling it OK.

When you say low, how low did you go? [Cool]

Posted by JustMeInCT (Member # 7237) on :

I was on Minocycline - 100mg pill 2x a day - for Lyme.

After 10 days, I developed a bad full body rash and had to stop taking it.

I am not sure what is next for me in terms of treatment.

I also take Avonex 2x a week for MS.

Was dxed for MS 8 years ago - haven't missed a day of work due to it.

Posted by Littlesprout (Member # 7406) on :

RE; Avonex - so the combo is working for you? That is good, did you ever try Copaxone? I was told by Dr K that copaxone was the only MS drug OK with lyme. I know another lymie that is doing great with copaxone/abx combo.

I am doing high dose IVIG/abx. It has helped some, I did Copaxone last yr for 4mos. Looking back it is hard to say if it helped. I know the daily shots are very painful and two docs said the side effects are rough.