30: Possibly a variant of outer surface protein A.
31: Outer surface protein A (osp A). 34: Outer surface protein B (osp B).
39: Unknown what this antigen is, but based on research at the National Institute of Health (NIH), other Borrelia (such as Borrelia recurrentis that causes relapsing fever), do not even have the genetics to code for the 39 kDa antigen, much less produce it. It is the most specific antibody for borreliosis of all.
41: Flagella or tail. This is how Borrelia burgdorferi moves around, by moving the flagella. Many bacteria have flagella. This is the most common borreliosis antibody.
In my clinical experience, if a patient has symptoms suspicious for borreliosis, and has one or more of the following bands, there is a very high probability the patient has borreliosis.
These bands are 18, 22, 23-25, 28, 30, 31, 34, 37, 39, 41, 83, and 93. This is true regardless of whether it is IgG or IgM..
Posted by Lymetoo (Member # 743) on :
Be sure to read the entire link...lots of valuable information!! Posted by feesher (Member # 6243) on :
Question about that "41" band:
41: Flagella or tail. This is how Borrelia burgdorferi moves around, by moving the flagella. Many bacteria have flagella. This is the most common borreliosis antibody.
Does this mean there was detection of (is it protein) for a flagella in general - could be another bug? Or is it specific for the lyme flagella?
Posted by Lymetoo (Member # 743) on :
My brain isn't working too well today.
Posted by SForsgren (Member # 7686) on :
31, 34, and 39 are important. The positive 39 alone would indicate some serological evidence of Lyme infection.
Posted by Lymetoo (Member # 743) on :
From dr C's link:
"Controversy exists about band intensity. Many would say the " +/-" equivocal bands are not significant. The problem I have with that, is that there are "-" negative bands. The lab has no trouble calling some bands negative. So they must be seeing something when they put "+/-" at some bands.
The only thing that makes sense, is that there is a little bit of that antibody present in your serum. If the "+/-" equivocal is reported on the borrelia associated bands, it is usually significant, in my clinical experience. This is a strong clue that I am on the right track.
Instead of ignoring these, they should be a red flag to keep pursuing a laboratory diagnosis. Giving patients 4 weeks of antibiotics (usually tetracycline, 500 mg, 3 times a day), will convert a negative or equivocal Western blot to positive in about 36% of cases."
Equivocal is now called "indeterminant" or IND.
Posted by feesher (Member # 6243) on :
Just for reference, I found this in the ILADS document found here:
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