This is topic Western Blot Results and Treatment Plan in forum Medical Questions at LymeNet Flash.


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Posted by Momoftwo (Member # 8732) on :
 
I would appreciate some advice from the experts out there.

After having some bands positive on Quest, I asked my doctor to do an Igenex test (IGM only). The results came back positive but he tells me that few doctors would treat and that his recommended treatment is 4 mos of antibiotic treatment (minocin) and if the symptoms do not go away then it isn't Lyme.

The WB results were.

18 kDa ++
22 kDa -
**23-25 kDa ++
28 kDa -
30 kDa ++
**31 kDa IND
**34 kDa -
37 kDa -
**39 kDa IND
**41 kDa- ++
45 kDa -
58 kDa -
66 kDa -
73 kDa -
83 kDa -
93 kDa ++

I do have many of the symptoms of Lyme and have many other things (MS, RA, Lupus etc) ruled out.

Thank you.

Denise
 
Posted by Monica (Member # 224) on :
 
Your doctor is grossly uninformed. Please go to the Seeking a Doctor forum and ask for info for a Lyme Literate Doctor in your area.
 
Posted by Corgilla (Member # 4066) on :
 
Hi,

I'm not sure why you did IgM only Western Blot test. The tests show your exposure to Borrelia and IgG shows that as well.

If this is an IgM result, you are definitely CDC postive for Lyme with active infection.

You need to find a Lyme Literate doctor. You have no idea if you have any coinfections along with Lyme. How does your doc know that minocycline is the antibiotic that will treat your particular strain of Borrelia?

I don't know where you are in Canada but there is a great Canadian website called canlyme. I can't remember what the ending is .net .org .com. One of those. Maybe they can point you in the right direction for a doc that knows how to treat tick born diseases.

I don't know how up on Canadian LLMD's our people from "Seeking a Doctor" are but it never hurts to try there too.

Take care,

Corgilla
 
Posted by Lymetoo (Member # 743) on :
 
Ho Boy! You have Lyme all over the place! Four months of treatment MIGHT be OK if you received the tick bite VERY recently. [like within the last few days or weeks]

The 4 mo of treatment will likely cause you to herx [a worsening of symptoms], but that is a GOOD sign that you are on the right track.

When you kill off the spirochetes they throw off toxins. That makes you FEEL worse, but you're actually on your way to getting better. Hope that makes sense!!

Please read through this link carefully. You will see that your test is POSITIVE.

Many drs in Canada and the US like to IGNORE Lyme patients because they don't want to lose their licences for treating longer than the usual "4 weeks" they are taught to do.

here is the link

Western Blot explanation:
http://flash.lymenet.org/ubb/Forum1/HTML/022767.html


Hope you will begin searching for a dr who will adequately treat you. To do otherwise would have dire consequences for your future.
 
Posted by SForsgren (Member # 7686) on :
 
Read the info on the Western Blot on my site below under "Testing". That looks like a clear Lyme positive test.
 
Posted by Lymetoo (Member # 743) on :
 
Your test showed these bands as positive or equivocal (IND) Read in the link I gave you about "equivocal" and what it means. That is now referred to as IND or "indeterminate."


18: An outer surface protein.

23-25: Outer surface protein C (osp C).

30: Possibly a variant of outer surface protein A.

31: Outer surface protein A (osp A). 34: Outer surface protein B (osp B).

39: Unknown what this antigen is, but based on research at the National Institute of Health (NIH), other Borrelia (such as Borrelia recurrentis that causes relapsing fever), do not even have the genetics to code for the 39 kDa antigen, much less produce it. It is the most specific antibody for borreliosis of all.

41: Flagella or tail. This is how Borrelia burgdorferi moves around, by moving the flagella. Many bacteria have flagella. This is the most common borreliosis antibody.

93: The DNA or genetic material of Borrelia burgdorferi.

In my clinical experience, if a patient has symptoms suspicious for borreliosis, and has one or more of the following bands, there is a very high probability the patient has borreliosis.

These bands are 18, 22, 23-25, 28, 30, 31, 34, 37, 39, 41, 83, and 93. This is true regardless of whether it is IgG or IgM.

This was written by Dr C of MO. He is one of the best LLMD's in the US.
 
Posted by bpeck (Member # 3235) on :
 
93 kDa is usually expressed in late Lyme.. So is 18 kDa.

Agreed- you need a Doc that knows someting (hopefully alot) about Lyme. There's no doubt you have Lyme, and with your IgM antibodies this active- it means the spirochetes are active.

Barb
 
Posted by Momoftwo (Member # 8732) on :
 
Thank you very much for your replies.

My doctor is in the U.S. but I have recently been referred to a (Lyme) specialist here in Toronto. I am now glad that I have the referral.

I do not remember ever being bitten by a tick. However my father had chronic Bells Palsy, eye infections, limb pain, numbness and many of the other symptoms that I now have.

Thank you again,

Denise
 
Posted by Lymetoo (Member # 743) on :
 
Bells Palsy is a BIG red flag for Lyme, along with the other symptoms you mentioned. Here is a list of Lyme symptoms:

Lyme Disease Symptoms List
1. Unexplained fevers, sweats, chills, or flushing
2. Unexplained weight change--loss or gain
3. Fatigue, tiredness, poor stamina
4. Unexplained hair loss
5. Swollen glands: list areas____
6. Sore throat
7. Testicular pain/pelvic pain
8. Unexplained menstrual irregularity
9. Unexplained milk production: breast pain
10.Irritable bladder or bladder dysfunction
11.Sexual dysfunction or loss of libido
12.Upset stomach
13.Change in bowel function-constipation, diarrhea
14.Chest pain or rib soreness
15.Shortness of breath, cough
16.Heart palpitations, pulse skips, heart block
17.Any history of a heart murmur or valve prolapse?
18.Joint pain or swelling: list joints_____________
19.Stiffness of the joints, neck, or back
20.Muscle pain or cramps
21.Twitching of the face or other muscles
22.Headache
23.Neck creeks and cracks, neck stiffness, neck pain
24.Tingling, numbness, burning or stabbing sensations, shooting pains
25.Facial paralysis (Bell's Palsy)
26.Eyes/Vision: double, blurry, increased floaters, light sensitivity
27.Ears/Hearing: buzzing, ringing, ear pain, sound sensitivity
28.lncreased motion sickness, vertigo, poor balance
29.Lightheadedness, wooziness
30.Tremor
31.Confusion, difficulty in thinking
32.Diffculty with concentration, reading
33.Forgetfuiness, poor short term memory
34.Disorientation: getting lost, going to wrong places
35.Difficulty with speech or writing
36.Mood swings, irritability, depression
37.Disturbed sleep-too much, too little, early awakening
38.Exaggerated symptoms or worse hangover from alcohol

Glad you have an appointment. Now it's time to work on your dad! Wish I'd had the chance to do the same for my dad.
 


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