I am looking for information on the effects of Lyme disease on blood. Does it cause coagulation problems??
Does anyone know if it has an effect on anti-cardio lipin antibodies?
How about the Leiden factor V ???
I am researching as fast as I can, but would love it if anyone has some references.
Thanks, Ann - OH
Posted by SForsgren (Member # 7686) on :
It most definitely causes hypercoagulation. It is one of the mechanism that the bugs use to stay protected by hiding the the layers of fibrin.
You can also find some information on the Anticardiolipin in the Mold Warriors book and maybe at www.MoldWarriors.com. Posted by Jill E. (Member # 9121) on :
Look at the site for Hemex Labs, www.hemex.com, for their coagulation tests and articles by David Berg. He has been giving interviews to some of the Chronic Fatigue Syndrome and the Lyme sites and newsletters regarding this issue.
Jill
Posted by riversinger (Member # 4851) on :
In the book Mold Warriors, the author states that he sees a higher than normal incidence of anticardiolipin antibodies in people who are affected by biotoxins, of which Lyme is one.
He also sees an increase in CRP, PAI-1, C3a, and MMP-9, all blood markers that can affect the heart and circulation.
He relates cases where there is a loss of circulation suficient to threaten a limb, as well as one where the heart is affected in a man otherwise not considered at risk for a heart attack.
I don't think the info is availble anywhere other than the book. www.moldwarriors.com It isn't just about mold, it also talks extensively about Lyme.
Posted by dcook60 (Member # 5579) on :
so far, i haven't run across any CLOTTING QUESTIONS or posters with the opposite problem.....that of TOO MUCH BLEEDING. i've had eleven surgeries. in some of them, i almost bled "out" (aka "to death")
so i probably have not "hypercoagulability" but "hypocoagulability". anyone else with this bleeding tendency??
i'm in shock and depression with the state of medical care today. a sick person has no choice but to direct their own medical care. FINALLY, after years and years of nobody caring but me, i've pushed to see a hematologist.
perhaps at last i will have an answer to this bleeding disorder, whatever it may turn out to be. obviously, i'm still here after 65 years, but i probably face more surgeries in my future, and it would certainly be GOOD TO KNOW what's wrong w/my blood! dianne
Posted by Ann-OH (Member # 2020) on :
Thank you so much! I knew I could count on people here.
Ann - OH
Posted by snowflake (Member # 8950) on :
Yes, dcook60, lyme can cause excessive bleeding too. There are several document cases in published journals where they discuss a link between thrombocytic purpura with cases of Lyme borreliosis.
Thrombocytic purpura can occur after an infection where an autoimmune like reaction occurs and the body begins to attack its own platelets. This will cause excessive bleeding, bruising, and petechiae. I think it would be a good idea for you to see a hematologist. Other conditions may also cause this and this needs to be addressed.
Do you take any natural supplements such as garlic that could cause thinning of the blood?
Posted by snowflake (Member # 8950) on :
Blood, 15 October 2003, Vol. 102, No. 8, pp. 2843-2850. Prepublished online as a Blood First Edition Paper on July 10, 2003; DOI 10.1182/blood-2003-02-0426.
Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever borreliosis
Abstract: Thrombocytopenia is common in persons infected with relapsing fever Borreliae. We previously showed that the relapsing fever spirochete Borrelia hermsii binds to and activates human platelets in vitro and that, after platelet activation, high-level spirochete-platelet attachment is mediated by integrin IIb3, a receptor that requires platelet activation for full function. Here we established that B hermsii infection of the mouse results in severe thrombocytopenia and a functional defect in hemostasis caused by accelerated platelet loss.
Disseminated intravascular coagulation, immune thrombocytopenic purpura, or splenic sequestration did not play a discernible role in this model. Instead, spirochete-platelet complexes were detected in the blood of infected mice, suggesting that platelet attachment by bacteria might result in platelet clearance. Consistent with this, splenomegaly and thrombocytopenia temporally correlated with spirochetemia, and the severity of thrombocytopenia directly correlated with the degree of spirochetemia. Activation of platelets and integrin IIb3 were apparently not required for bacterium-platelet binding or platelet clearance because the bacterium-bound platelets in the circulation were not activated, and platelet binding and thrombocytopenia during infection of 3-deficient and wild-type mice were indistinguishable. These findings suggest that thrombocytopenia of relapsing fever is the result of platelet clearance after 3-independent bacterial attachment to circulating platelets.
Posted by snowflake (Member # 8950) on :
thanks for the answer, snowflake, but thrombocytopenia doesn't apply to me. my platelets seem just fine. and i've had the bleeding tendency since childhood surgeries.
i will see the hematologist in 5 weeks. the ones where i live are all CANCER specialists. eeeeeeeeek, i don't even want to be associated with cancer in any way shape or form.....dianne
Posted by mag (Member # 8920) on :
hi dc 60 i have excessive bruising and bleeding if i cut my self -my platelet count is over 500k i am a mess but heaven is not too soon!
doesn't babesia affect the coag factors the blood viscosity is elevated -elevates the esr
to keep it thin -aome take garlic, black walnut oil, and lemons -there is that german herb - reuchus---(sp) that works like heparin thats all folks mags
Posted by Marnie (Member # 773) on :
Bb locks onto the heparin receptor in the endothelial cells which line the blood vessels and lymph vessels. Likely using Zn in its outer cell wall to do this.
Unlike all other pathogens (exception: mycoplasms) Bb does not contain a LPS outer layer. It contains a Zn+cholesterol outer layer which functions similarly ie., fibrin coat/biofilm/slime layer. Globs of infection where other co-buddies in crime can do their jobs too. Bb esp. likes babesia which lowers iron, 'cause Bb doesn't especially like iron...which carries oxygen.
Does locking onto the heparin receptor cause coagulation problems, you bet!
Does giving hepain sodium help? Yes, in fact it even will kill some Bb. Notice I said some. It's hard to give ENOUGH heparin...dangerous.
This is all documented.
(28) Bb locks onto a heparin receptor. It may be using fibrin to cloak itself and thus avoid detection/destruction. Magnesium may reduce insoluble fibrin.
Go to Pubmed and type in "borrelia burgdorferi heparin" or "lyme heparin" for additional info.
Oh...I forgot...
A reduction of PFK also can cause anemia. This happens to our astronauts. It is due to oxidative stress. The anemia could account for the hypocoagulation issues.