Int Microbiol. 2001 Dec;4(4):209-15. Related Articles, Links
Susceptibility of motile and cystic forms of Borrelia burgdorferi to ranitidine bismuth citrate.
Brorson O, Brorson SH.
Department of Microbiology, Vestfold Sentralsykehus, Tonsberg, Norway.
Gastrointestinal symptoms accompanying Lyme disease have not been considered in the treatment of Lyme patients yet. Here we examine the effect of ranitidine bismuth citrate (RBC) on motile and cystic forms of Borrelia burgdorferi in vitro, to determine whether it could cure this bacterial infection in the gastrointestinal tract.
When motile forms of B. burgdorferi were exposed to RBC for 1 week at 37 degrees C, the minimal bactericidal concentration (MBC) was > 64 mg/ml. At 30 degrees C, the MBC was > 256 mg/ml. When the incubation lasted for 2 weeks at 37 degrees C, the MBC dropped to > 2 mg/ml.
Bismuth aggregates were present on the surface of B. burgdorferi when RBC > or = MBC, as shown by transmission electron microscopy (TEM). Cystic forms of B. burgdorferi, exposed to RBC for 2 weeks at 37 degrees C, were examined by cultivation in BSK-H medium (Sigma B3528). They were stained with acridine orange (pH 6.4, pH 7.4) and studied by TEM. The MBC for RBC for young cystic forms (1 day old) and old cysts (8 months old) was estimated to be > 0.125 mg/ml and > 2 mg/ml, respectively.
Bismuth aggregates were attached to the cysts and, in some, the pin-shaped aggregates penetrated the cyst wall. The bismuth aggregates also bound strongly to blebs and granules of B. burgdorferi when RBC > or = MBC. When B. burgdorferi is responsible for gastrointestinal symptoms, bismuth compounds may be candidates for eradication of the bacterium from the gastrointestinal tract.
PMID: 12051564 [PubMed - indexed for MEDLINE]
The above is Tritec. It is made by an American company, but only sold in Europe. No "need for it here"...Yea, right.
Yes..."mind-gut connection"...in many ways...neurotransmitters esp. There is even a book by that name!
Healing starts in the gut. We HAVE to have a healthy gut so we can absorb and make nutrients there. Many of our B vitamins are made for us by the "good guys" and many of our neurotransmitters need those vitamins (in addition to minerals and amino acids).
Posted by luke339 (Member # 8580) on :
Brilliant website
Posted by Nal (Member # 6801) on :
Thanks Marnie! Yes, he is actually retired now but I see his partner in the practice. However, he keeps me updated via email with new info and such. He is such a great guy!
Nancy
Posted by trails (Member # 1620) on :
Virginia Sherr (the author of the article) is an ILADS board member, not a CA Lyme Disease Association member. She has written extensively on bowel/tummie issues and Lyme and babs. She is a practicing physchiatrist and both she and her husband were/are afflicted.
Thanks for bringing this to our attention!
A great article for tummie people!
Posted by trails (Member # 1620) on :
Oh, I see, WOOOOPS, yes, the website is from a CALDA member, the article is written by Dr Sherr.