Toll-like receptors in Borrelia burgdorferi-induced inflammation.
Singh SK, Girschick HJ.
Pediatric Rheumatology, Immunology and Infectious Diseases, Children's Hospital, University of Wurzburg, Wurzburg, Germany.
Lyme arthritis, the most common manifestation of late Lyme disease, has been associated with the presence of Borellia burgdorferi in the joint. However, it is still unclear whether the pathogen itself is able to elicit such a sustained inflammatory response, or whether an aberrant immunological reaction of the host is the main driving force. Borrelia antigens, including lipoproteins, flagellin and DNA, are ligands of Toll-like receptors, and can thus elicit a strong stimulation of host cells, such as neutrophils, mononuclear cells and resident tissue cells. Understanding the molecular basis of the signalling events caused by Borrelia lipoproteins will lead to a greater understanding of inflammation in Lyme arthritis and, hopefully, new treatment strategies for chronic antibiotic-resistant disease.
PMID: 16842565 [PubMed - in process]
Posted by treepatrol (Member # 4117) on :
Toll-like receptors in Borrelia burgdorferi-induced inflammation.
Singh SK, Girschick HJ.
Pediatric Rheumatology, Immunology and Infectious Diseases, Children's Hospital, University of Wurzburg, Wurzburg, Germany.
Lyme arthritis, the most common manifestation of late Lyme disease, has been associated with the presence of Borellia burgdorferi in the joint. However, it is still unclear whether the pathogen itself is able to elicit such a sustained inflammatory response, or whether an aberrant immunological reaction of the host is the main driving force. Borrelia antigens, including lipoproteins, flagellin and DNA, are ligands of Toll-like receptors, and can thus elicit a strong stimulation of host cells, such as neutrophils, mononuclear cells and resident tissue cells. Understanding the molecular basis of the signalling events caused by Borrelia lipoproteins will lead to a greater understanding of inflammation in Lyme arthritis and, hopefully, new treatment strategies for chronic antibiotic-resistant disease.
PMID: 16842565 [PubMed - in process]
2006 Aug;12(8):705-17 dated thats odd am I missing something?
Posted by newdurham77 (Member # 7815) on :
Not really odd. Sometimes, pubmed publishes abstracts the month before the article appears. This article looks like it will be published next month.
Posted by lou (Member # 81) on :
Seems to me this directly counters another recent article that concluded lyme arthritis could exist after the bacteria were gone (because the researchers could not find them). In short, if the bacteria are gone, no more treatment needed.
Posted by GiGi (Member # 259) on :
Heavy Metals are usually in the joints also, especially the knee joints and the feet. There are a variety of neurotoxins that take part in this whole scenario causing problems.
Posted by Aniek (Member # 5374) on :
My knee was inflammed on and off throughout high school. They always wanted to drain the fluid to test it. They thought the Lyme might show in the fluid.
Of course, since it was "chronic recurring water on the knee" rather than just "chronic" everytime I made it to a doctor, my knee wouldn't be inflamed. Never got it drained or tested.