Taken with Mepron and Zithromax or Cleocin and Quinine.
One study found that 89% of those that took Trimethoprim with one of the above combinations were cured of Babesia while many of those that did not include it relapsed.
Posted by Lymetoo (Member # 743) on :
I took trimethoprim with Bactrim. It helped SOMETHING!
Posted by Corgilla (Member # 4066) on :
Hi,
I read this study too and I have no idea why our LLMDs haven't picked up on it.
Corgilla
Posted by NP40 (Member # 6711) on :
WHERE"S THE STUDY ? !!!! Posted by treepatrol (Member # 4117) on :
Medical Care: Most of the otherwise healthy patients infected by B microti appear to have a mild illness and recover without specific chemotherapy; however, treatment is recommended for all diagnosed cases to prevent sequelae and potential transmission through blood donation.
Babesiosis is generally treated with a combination of clindamycin (20 mg/kg/d for children; 300-600 mg IV/IM q6h for adults) and oral quinine (25 mg/kg/d for children; 650 mg q6-8h for adults) administered for 7-10 days. Occasional failure of this therapy has been reported. A combination of atovaquone and azithromycin appears to be a promising alternative. In a prospective nonblinded randomized study in 2000, Krause and colleagues found that a regimen of atovaquone (750 mg q12h) and azithromycin (500 mg on day 1 and 250 mg/d thereafter) was as effective as a combination of clindamycin (600 mg q8h) and quinine (650 mg q8h) in producing a clinical response and producing the clearance of parasitemia. All patients were treated for 7 days. Adverse effects were reported by 15% of the patients who received atovaquone and azithromycin, as compared with 72% of those who received clindamycin and quinine. The combination of clindamycin, doxycycline, and azithromycin was successfully used in a patient who was allergic to quinine. The combination of pentamidine with trimethoprim-sulfamethoxazole was reported to be successful in the treatment of B divergens infection in a patient in France who was splenectomized. The antitrypanosomal drug diminazene aceturate is effective against B microti infections in animals and has been administered to one patient who recovered from B microti infection. This patient developed a Guillain-Barr�-like disorder. Diminazene was also used unsuccessfully in a fatal case of babesiosis due to B divergens. Exchange transfusions are used in patients who are profoundly ill with high levels of parasitemia and hemolysis. When used concurrently with chemotherapy, exchange transfusion reduces the level of parasitemia and may remove toxic erythrocyte, babesial, or macrophage-produced factors.
Posted by treepatrol (Member # 4117) on :
I believe that Trimethoprim is also called septra. My doc just threw this into my babs mix and I am herxing like crazy. So far my fevers have broke, but the burning has increased. I guess it is killing something.
Posted by charlie (Member # 25) on :
trimethoprim is one of the components of bactrim which is the SAME thing as septra.
bactrim was once the drug of choice for PCP pneumonia, a type of PARASITIC pneumonia that aids patients get.
Mepron was developed to combat PCP pneumonia, but doesn't contain sulfa because approx. 25% of the populace can't tolerate sulfa.
So apparently bactrim works along the same lines as mepron...but it's real cheap and toxic to some....probably why there's so little interest in it.
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