1: Med Hypotheses. 2006 Dec 29; [Epub ahead of print]
Lyme borreliosis and multiple sclerosis are associated with primary effusion lymphoma.
Batinac T, Petranovic D, Zamolo G, Petranovic D, Ruzic A.
Department of Dermatovenerology, Rijeka University Hospital, Kresimirova 42, 51000 Rijeka, Croatia.
Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by chronic inflammation and demyelination. Studies suggested that the viral, especially Epstein-Barr virus infection, and bacterial infections, especially Borrelia burgodorferi infection, play a role in etiology of MS.
MS prevalence parallels the distribution of the Lyme disease pathogen B. burgdorferi. Criteria used for diagnosis of MS can also be fulfilled in other conditions such as Lyme disease, a multisystem disorder resulting from infection by the tick-borne spirochete, B. burgdorferi.
In the late period of Lyme disease demyelinating involvement of central nervous system can develop and MS can be erroneously diagnosed. A Lyme borreliosis can mimick central nervous system lymphoma.
Also, B. burgdorferi has been implicated not only in etiology of MS, but also in etiology of lymphoma.
Studies suggested that there is an increased risk of non-Hodgkin lymphoma in patients, who had a history of autoimmune diseases such as MS and that both non-Hodgkin's lymphomas and Hodgkin's disease were associated with Epstein-Barr virus infection.
A small group of lymphomas called primary effusion lymphomas (PEL) is a recently individualized form of non-Hodgkin's lymphoma (WHO classification) that exhibit exclusive or dominant involvement of serous cavities, without a detectable solid tumor mass.
These lymphomas have also been linked to Epstein-Barr virus and human herpes virus type 8 infections but virus negative cases have been described.
Therefore, we propose that MS and neuroborreliosis are linked to central nervous system primary effusion lymphomas.
As a first step in confirming or refuting our hypotheses, we suggest a thorough study of CSF in the patients suspected for the diagnosis of MS and Lyme borreliosis.
PMID: 17197115 [PubMed - as supplied by publisher]
Posted by pq (Member # 6886) on :
i recall having read that b-cell lympoma(s) disappeared after abx treatmet. archives on one of the, non-flash-discussion sectionsa, though, i don't recall which section.
Posted by MagicAcorn (Member # 8786) on :
Wow !
Interesting - thanks for posting this.
Posted by humanbeing (Member # 8572) on :
My llmd wants me to get a ct scan to rule out lymphoma...what would be the treatment for it if you have lyme too?
Posted by clinlabscientist (Member # 9284) on :
With low CD 57 levels (natural killer lymphocyte)reported in Lyme patients, this kind of correlation with a malignancy is not surprising.
These cells have search and destroy duty for malignant cells.....not to mention that the infection could serve as the oncogenic stimuli to develop the malignancy to begin with and then with a reduced immune response.....It is scary....
?????
Posted by kelmo (Member # 8797) on :
Holy Cow...one more thing to think about. Thanks for posting this. I have a teenager, and they seem to be the majority of hodgkin's victims.
Posted by MagicAcorn (Member # 8786) on :
I have a teenager, and they seem to be the majority of hodgkin's victims.
I thought the same thing Kelmo.
Posted by northstar (Member # 7911) on :
Jackie Kennedy Onassis died from non-hodgkins lymphoma. She was avid horsewoman, and frequented Martha's Vineyard (not sure that is spelled right), and grew up in that area.
![[Big Grin]](biggrin.gif)