I'm hoping to correspond wtih anyone who took Alinia? What happened? Let me know, O.K.?
Kayda
Posted by johnlyme1 (Member # 7343) on :
I know of 1 other personally who is also seeing my llmd who has also taken this. We Both use the same energenic tester and both of us tested high on the use of this med.
I took it for a crypto infetion along with toxoplasma and babs. All three of these protozoa bugs. I also used it at the same time for the cyst form of lyme. This med also works on giardia and a couple of other parasites. It also worked on the lyme. I had very good results and my friend who was on it had favorable results. Oh ya both of us also had pneumocystis due that our immune systems were so low. It also helped with that too. A very interesting med. Side effect were minimal.
Posted by bv (Member # 9578) on :
I take Alinia 500 mg 1x day. Been taking it for 3 months. Also take doxy 100/200 mg 2x day.
My llmd substituted alinia for flagyl b/c alinia easier on the gi system & much less neuro side effects than flagyl. Several months ago there was quite a discussion on this board about alinia as a cyst buster.
My llmd says alinia is essentially same as tinidazole & is a cyst buster for LD. Several other folks here did not believe alinia was (is) a cyst buster.
I have had minimal side effects & find Alinia much easier on my body than flagyl. Good Luck.
Posted by Kayda (Member # 10565) on :
This sounds like a very good all-around med. I like the idea that it can hit so many different organisms & that it is not as harsh on the GI tract.
Did you herx on this med? If you did, when did you notice the herx?
kayda
Posted by johnlyme1 (Member # 7343) on :
The babs herx for me was quick. By the 2nd dose I got the babs headake and then it tapered after about 3 days. The lyme stuff started at about 4 days into the med. I felt it hit a couple of my problem areas. Thats about all I can recall.
As far as hitting my crypto, my gi problem from the crypto just cleared out within about 8 days.
But I did notice that I had to pay attention to my lymph system. With the various bugs getting killed off my lymph system did start to get sluggish. It took about a week to get it back up to speed.
Posted by Kayda (Member # 10565) on :
John,
Thanks for letting me know. That sounds like a very quick herx reaction! Glad you made it through :-) At least you knew it was working!
When it started clogging up your lymph, did you back off the Alinia or did you do something to keep your lymph moving? Did yout ake activated charcoal, drink extra water or do something to help mop up the mess?
Thanks! Kayday
Posted by johnlyme1 (Member # 7343) on :
Kayda,
I am constantly working on detox. Lymph massage, colonics, drainage support and so on. The homeopathic that you have seen has some good stuff for drainage.
Posted by herxdoll (Member # 10739) on :
i have been on it since september and have tolerated it quite well. on the other hand, i still have some babs symptoms so the jury is still out as to its long lasting effects. my only heads-up would be the cost. 1tablet twice a day for a month before insurance was $799. my insurance picked up $639. my llmd was surprised insurance paid at all and told me i didn't have to pick up the prescrip if they didn't, we would use something else. luckily insurance covered 3 refills and we have been pulsing it every other day - alternating with zithromax - so it has lasted quite some time.
Posted by Kayda (Member # 10565) on :
Wow! That's really expensive! That is amazing that your insurance paid for it.
My dr. tested me for other medications, but I'm allergic to all the rest of them. I'll see what happens when it's time to get my script.
Kayda
Posted by digirl02 (Member # 7177) on :
Well I took my first dose of Alinia with Zithromax combo early January. First, I started two Zithromax - one on Wed and one on Saturday..
Alinia - 500mg and Zith - 600 mg supposed to start out above then increase twice daily..never got that far that's for sure...
My Alinia was suppose to be Mon/Tues/Thurs/Fri
But, because it was the first time i was using this combo for babs treatment, I started out slow.
I took the two ziths as recommended but only took the Alnia twice a week vs 4x / week just because I know my body.
After about 1 week, my entire body, from the balls of my heels to the tops of my shoulders I broke out into a rash, hives/welts and the most severe joint pain i ever endured.
So, I thought it was an allergic reaction to the Alinia but after discussion w/my LLMD he thought more of a herx due to die off.
He had me stop for about a week or two (because that's how long the pain and rash stayed around) and start back at an even slower pace.
Well, i did the two zith one week and the following week re-introduced the Alinia after dinner one night - by 4:00am the next morning - same thing happened...
So, I was told to stop and we will readdress on my March 12 visit..
I got the Alinia free through Romark Labs because I don't have the insurance..I try to work the pharmaceuticals and also through Pfizer got my zith free for three months..
I truly don't want to have to change this combo (because of now having 3 months of free meds) and would actually like to hear what others think of my experience...is it a really bad herx and I need to deal with it ? because it's a herx I'm not ready to take...again discussion w/llmd next month.
I'm curious that no one else had this reaction to Alinia so that's why i'm posting to your initial post about Alinia...
My reaction was bad, but I hope yours isn't.
Anyone else want to comment to me can email me at [email protected] instead of continuing this post (about me)..
Good luck Diane
Posted by Aniek (Member # 5374) on :
I just started Alinia yesterday. It's not for Lyme. I've been having all kind of GI symptoms, and my LLMD wanted to see if it helps.
She told me to take it for 3 days, if I feel better stay on for 30. If I feel the same or worse, stop. I'm pretty nauseous right now.
I think the reason she wants me to stop if I feel worse is that the GI symptoms have caused me to lose weight. I'm ok now, but I really can't lose more weight. So she probably doesn't want me in a GI herx.
Posted by johnlyme1 (Member # 7343) on :
I was only doing one 500mg of Alinia a day, but again this was after 17 months of previous treatment. I would imagine that if one has a high bug load that the reaction could be rather intense.
Posted by treepatrol (Member # 4117) on :
PRECAUTIONS General: The pharmacokinetics of nitazoxanide in patients with compromised renal or hepatic function have not been studied. Therefore, nitazoxanide must be administered with caution to patients with hepatic and biliary disease, to patients with renal disease and to patients with combined renal and hepatic disease. Information for Patients Alinia Tablets and Alinia for Oral Suspension should be taken with food. Diabetic patients and caregivers should be aware that the oral suspension contains 1.48 grams of sucrose per 5 mL. Drug Interactions Tizoxanide is highly bound to plasma protein (>99.9%). Therefore, caution should be used when administering nitazoxanide concurrently with other highly plasma protein-bound drugs with narrow therapeutic indices, as competition for binding sites may occur (e.g., warfarin). In vitro metabolism studies have demonstrated that tizoxanide has no significant inhibitory effect on cytochrome P450 enzymes. Although no drug-drug interaction studies have been conducted in vivo, it is expected that no significant interaction would occur when nitazoxanide is co-administered with drugs that either are metabolized by or inhibit cytochrome P450 enzymes. Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term carcinogenicity studies have not been conducted. Nitazoxanide was not genotoxic in the Chinese hamster ovary (CHO) cell chromosomal aberration assay or the mouse micronucleus assay. Nitazoxanide was genotoxic in 1 tester strain (TA 100) in the Ames bacterial mutation assay. Nitazoxanide did not adversely affect male or female fertility in the rat at 2,400 mg/kg/day (approximately 20 times the clinical adult dose adjusted for body surface area). Pregnancy: Teratogenic Effects Pregnancy Category B: Reproduction studies have been performed at doses up to 3,200 mg/kg/day in rats (approximately 26 times the clinical adult dose adjusted for body surface area) and 100 mg/kg/day in rabbits (approximately 2 times the clinical adult dose adjusted for surface area) and have revealed no evidence of impaired fertility or harm to the fetus due to nitazoxanide. There are, however, no adequate and well-controlled studies in pregnant women. Nursing Mothers It is not known whether nitazoxanide is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when nitazoxanide is administered to a nursing woman. Pediatric Use A single Alinia Tablet contains a greater amount of nitazoxanide than is recommended for pediatric dosing and should therefore not be used in pediatric patients 11 years or younger. Alinia for Oral Suspension should be used for dosing nitazoxanide in pediatric patients (see DOSAGE AND ADMINISTRATION). Safety and effectiveness of Alinia for Oral Suspension in pediatric patients less than 1 year of age have not been studied. Geriatric Use Clinical studies of Alinia Tablets and Alinia for Oral Suspension did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. In general, the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy in elderly patients should be considered when prescribing Alinia Tablets and Alinia for Oral Suspension. As stated in the PRECAUTIONS section, this therapy must be administered with caution to patients with renal and or hepatic impairment. HIV-Infected or Immunodeficient Patients Alinia Tablets and Alinia for Oral Suspension have not been studied for the treatment of diarrhea caused by Giardia lamblia in HIV-infected or immunodeficient patients. Alinia Tablets and Alinia for Oral Suspension have not been shown to be superior to placebo for the treatment of diarrhea caused by Cryptosporidium parvum in HIV-infected or immunodeficient patients (see CLINICAL STUDIES). ADVERSE REACTIONS Alinia Tablets: In controlled and uncontrolled clinical studies of 1,657 HIV-uninfected patients age 12 years and older who received various dosage regimens of Alinia Tablets, the most common adverse events reported regardless of causality assessment were: abdominal pain (6.6%), diarrhea (4.2%), headache (3.1%) and nausea (3.0%). In placebo-controlled clinical trials using the recommended dose, the rates of occurrence of these events did not differ significantly from those of the placebo. In placebo-controlled trials of HIV-uninfected patients age 12 years and older who received Alinia Tablets for the treatment of diarrhea caused by Giardia lamblia or Cryptosporidium parvum, less than 1% of patients discontinued therapy because of an adverse event. Adverse events occurring in less than 1% of the patients age 12 years and older participating in clinical trials of Alinia Tablets are listed below: Body as a Whole: asthenia, fever, pain, allergic reaction, pelvic pain, back pain, chills, chills and fever, flu syndrome. Nervous System: dizziness, somnolence, insomnia, tremor, hypesthesia. Digestive System: vomiting, dyspepsia, anorexia, flatulence, constipation, dry mouth, thirst. Urogenital System: discolored urine, dysuria, amenorrhea, metrorrhagia, kidney pain, edema labia. Metabolic & Nutrition: increased SGPT. Hemic & Lymphatic Systems: anemia, leukocytosis. Skin: rash, pruritus. Special Senses: eye discoloration, ear ache. Respiratory System: epistaxis, lung disease, pharyngitis. Cardiovascular System: tachycardia, syncope, hypertension. Muscular System: myalgia, leg cramps, spontaneous bone fracture. Alinia for Oral Suspension: In controlled and uncontrolled clinical studies of 613 HIV-uninfected pediatric patients who received Alinia for Oral Suspension, the most frequent adverse events reported regardless of causality assessment were: abdominal pain (7.8%), diarrhea (2.1%), vomiting (1.1%) and headache (1.1%). These were typically mild and transient in nature. In placebo-controlled clinical trials, the rates of occurrence of these events did not differ significantly from those of the placebo. None of the 613 pediatric patients discontinued therapy because of adverse events.
Adverse events occurring in less than 1% of the pediatric patients participating in clinical trials of Alinia for Oral Suspension are listed below: Digestive System: nausea, anorexia, flatulence, appetite increase, enlarged salivary glands. Body as a Whole: fever, infection, malaise. Metabolic & Nutrition: increased creatinine, increased SGPT. Skin: pruritus, sweat. Special Senses: eye discoloration (pale yellow). Respiratory System: rhinitis. Nervous System: dizziness. Urogenital System: discolored urine. The adverse events seen in adult patients treated with Alinia for Oral Suspension were similar to those observed in adult patients treated with Alinia Tablets. OVERDOSAGE Information on nitazoxanide overdosage is not available. In acute studies in rodents and dogs, the oral LD50 was higher than 10,000 mg/kg. Single oral doses of up to 4,000 mg nitazoxanide have been administered to healthy adult volunteers without significant adverse effects. In the event of overdose, gastric lavage may be appropriate soon after oral administration. Patients should be carefully observed and given symptomatic and supportive treatment
From Link:
Alinia pdf Posted by clairenotes (Member # 10392) on :
For whatever this is worth...
I have not taken any of these meds yet, but in my research I was told that it is best to take albendazole first, then baltricide, then alinia.
Somehow, the order was important in reducing consequences.
Claire
Posted by digirl02 (Member # 7177) on :
treepatrol, i did receive all that information about alinia so therefore didn't think it was a reaction to the alinia because it didn't really say anything about side effects.
however, i originally got the alinia because of about a year of GI problems and the thought was possible c.diff or guardia.. but what turned out was wheat allergies, so now on gluten-free diet.
what i'm getting at is that alinia is still a method of treatment w/babs so do you and any of you think that i herxed extremely bad ?
I was doing fine since August and the diet change, until two surgeries back to back in october and november...
And i backslid....the babs symptoms started hitting me again so we decided to do the alinia/zith combo for it...
So if there is 'really no side effects' then do you'll think it was a horrible herx? diane
Posted by digirl02 (Member # 7177) on :
one more thing...i've gone from about 128 lbs to 98 lbs...say in last few months...could the weight vs the dose have anything to do with it ?
again, all discussion at next visit...but would appreciate any input