These host-derived proteins offer some protection to HIV; however, the acquisition of host DAF can only partially explain the measured resistance of HIV to complement-mediated lysis. It turns out that the human complement regulator factor H is even more crucial for HIV's resistance. Factor H is not a membrane-bound protein, so HIV does not acquire it during cell budding. Rather, one of its two major surface glycoproteins, gp41 (the other is gp120), binds to serum factor H (Pinter et al, 1995). The crucial importance of this interaction in mediating HIV resistance to complement is underscored by the finding that antibodies specific to the factor H binding region on gp41 allowed for efficient complement-mediated lysis. (Stoiber et al, 1996) This finding and others which demonstrate interactions between HIV surface proteins and complement regulatory molecules (Stoiber et al, 1995) are potentially important because they suggest a particular HIV vaccine strategy. [See my next section, next section
Lest the situation seem overly simple, HIV interacts with the complement system in a variety of other ways as well. For example, like many other pathogens, HIV binds to certain complement receptors and uses them to gain entry to cells. The full interaction of HIV with the human complement system remains to be elucidated.
Sialic acid Seems like acids play big role in binding in these vulnerable places displacing the normal binding of other virus,bacteria etc in this H factor area???
Borrelia burgdorferi, a spirochete transmitted to human hosts during feeding of infected Ixodes ticks, is the causative agent of Lyme disease. Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form of the disease and bind complement factor H (FH) and FH-like protein 1 (FHL-1) on the spirochete surface. Here we report the atomic structure for the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer that presents a novel target for drug design.BbCRASP-1 homodimer cure?
All has to do with factor H binding site gets messed up MAC process.
This is hard to follow
Thought I would repost this by itself.
Posted by Ruth Ruth (Member # 11059) on :
thanks. lots of big words tree. but looks like some gems in there.
Posted by treepatrol (Member # 4117) on :
The Mycobacterium tuberculosis exported repetitive protein (Erp [?]) is a virulence determinant required for growth in cultured macrophages and in vivo. [2006] From link Posted by treepatrol (Member # 4117) on :
H Factor Posted by treepatrol (Member # 4117) on :
inside joke up to be bald Posted by treepatrol (Member # 4117) on :
up
Posted by lou (Member # 81) on :
Sometimes I wonder if any human is smart enough to get to the bottom of things like this. Encouraging that some are trying, but can it be figured out by mere mortals? Well, I hope so!
Posted by treepatrol (Member # 4117) on :
Lou one step at a time or one bite at a time eventially you can walk over to the elephant and then one bite at a time eat it till its gone.
Posted by treepatrol (Member # 4117) on :
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