Vaccine. 2007;25(3):466-80(ISSN: 0264-410X Earnhart CG; Buckles EL; Marconi RT Department of Microbiology and Immunology,Medical College of Virginia at Virginia Commonwealth University, Richmond, VA 23298-0678, USA.
Lyme disease is the most common arthropod-borne disease in North America and Europe. At present, there is no commercially available vaccine for use in humans. Outer surface protein C (OspC) has antigenic and expression characteristics that make it an attractive vaccine candidate; however, sequence heterogeneity has impeded its use as a vaccinogen. Sequence analyses have identified 21 well defined OspC phyletic groups or "types" (designated A-U). In this report we have mapped the linear epitopes presented by OspC types B, K, and D during human and murine infection and exploited these epitopes (along with the previously identified type A OspC linear epitopes) in the development of a recombinant, tetravalent, chimeric vaccinogen. The construct was found to be highly immunogenic in mice and the induced antibodies surface labeled in vitro cultivated spirochetes.
Importantly, vaccination induced complement-dependent bactericidal antibodies against strains expressing each of the OspC types that were incorporated into the construct. These results suggest that an effective and broadly protective polyvalent OspC-based Lyme disease vaccine can be produced as a recombinant, chimeric protein.
[ 03. May 2007, 07:21 AM: Message edited by: treepatrol ]
Posted by treepatrol (Member # 4117) on :
yoooooohhhhhhooooooooooooooo
Posted by treepatrol (Member # 4117) on :
up
Posted by Truthfinder (Member # 8512) on :
But just the same.... who would volunteer to be a guinea pig to test it?
Would you, Tree (assuming there were no other barriers like already having Lyme)?
Tracy
Posted by treepatrol (Member # 4117) on :
Yes I would as Long as they are using the right peptides. This is OspC the one that all warm blooded recognize Posted by lou (Member # 81) on :
Hope they will be checking it to make sure it does not cause the same kind of problems that the OspA vaccine (LymeRix) caused.
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