How do these guys COME UP with this stuff???? ************************************************* 1: Int J Antimicrob Agents. 2008 Jan 14
Pharmacodynamics of doxycycline for chemoprophylaxis of Lyme disease: preliminary findings and possible implications for other antimicrobials.
Lee J, Wormser GP. Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA.
The purpose of this study was to begin to characterise the pharmacodynamic parameters of single-dose doxycycline for the prevention of Lyme disease following a tick bite.
Based on limited data from published human and murine studies, it was found that there is a direct correlation between efficacy rate and the area under the time-concentration of free antibiotic curve divided by the minimum inhibitory concentration (fAUC/MIC) (R(2)=0.74, using Pearson correlation), but not the maximum concentration of free drug in serum divided by the MIC (fC(max)/MIC) or the time that the free drug concentration remains above the MIC (fT>MIC).
To determine the possible implications of these findings for other antimicrobials, it was assumed that the pharmacodynamic properties of doxycycline would be pertinent to azithromycin, an antibiotic whose activity is known to correlate with AUC/MIC.
By making such an extrapolation and using pharmacokinetic modelling with conservative assumptions on MIC values against Borrelia burgdorferi, it is hypothesised that a single 500mg dose of azithromycin in humans should have comparable efficacy to doxycycline for the prevention of Lyme disease.
Additional experimental studies are needed to clarify more precisely the pharmacodynamic properties of doxycycline and to validate the accuracy of this hypothesis.
PMID: 18226504
Posted by adamm (Member # 11910) on :
What the $%^& brown cow?!?!?!?!?!?!?!?!?!?!?!?!?!?!?
What's even scarier is that doctors take this seriously.
[ 31. January 2008, 07:56 PM: Message edited by: adamm ]
Posted by JasonK (Member # 14071) on :
If only LOL - i would have cured on my second day! Posted by Tincup (Member # 5829) on :
I do not believe there has been ONE statement coming from that Camp that has been found to be accurate.... and has withstood the test of time.
Lyme is NOT a virus, the tests are no good, the vaccine failed, their diagnostic and treatment protocols failed, their reporting system is a joke... they are under investigation for illegal practices... and their "one-dose-cure-all" theory is so insane a 6 year old actually knows it doesn't work.
I think we need to send them each a bumper sticker saying...
A CLOSED MOUTH GATHERS NO FEET!
They keep this up and not even THEY will believe their own garbage anymore.
It is to the point of both stupid and funny.
You can see how desperate they are when their general articles and literature continue to NOT address the Lyme facts.. but they focus on kicking "advocacy groups" and "patients" and try to point out how they are wrong.
Give them the rope and they will hang themselves.
Of course this is only MY opinion.
Posted by treepatrol (Member # 4117) on :
Posted by Geneal (Member # 10375) on :
What's the half-life of zithromax? 72 hours I think.
Egads! Methinks it is the one dose cure.....again.....and again.....and again....
Tell you what. Place the author in a room full of ticks
Known to carry bb. Have him let at least one embed.
Then......take that 500mg of zith.
I agree. It is both stupid and funny!
Hugs,
Geneal
Posted by Robin123 (Member # 9197) on :
...only in their dreams...
Posted by jamescase20 (Member # 14124) on :
This is a travsaty I cannot believe what has happened to this great nation. We lost almost everything. You know, with all the underinsured and uninsured out there. Maybe we could just start a NEW health insurance compnay. Well every customer is a member on the board of directors. And its not for profit. The more smartly you get yourself treated with lower cost, but effective tx's. That way perhaps it would be affordable? I think its legal to start something like this too. Any interest? The man issue will be getting some health y folks in. But even these disases can be cheap...you dont need iv, then oral, quinine is great for me.
Posted by cjnelson (Member # 12928) on :
Unreal!!!!!!!!!!!!!!!!! Guess that means I am already cured!?!? WOW! Now if only my body would catch up to that theory it would be all good!
Posted by pingpong (Member # 13706) on :
"ser" is the spanish infinitive, "to be"
a "worm"...well, we know what a worm is...
thusly and hence, "to be, or not to be...a worm..." that is the question...
no disrespect mean't to those who do constructive work in the compost pile.
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