I've been on Minocylcine for 2 weeks, after vomiting with Doxycline for one day (took it with an empty stomach.) My symptoms are not getting any better, my legs ache, my neck hurts and a recurring headache. Should I expect the symptoms to gradually start getting better, or should I switch to another antibiotic? I take Minocycline 100mg 3X/day with food. Thanks!
Posted by dmc (Member # 5102) on :
Two weeks isn't enough time to decide if working or not.
Posted by Keebler (Member # 12673) on :
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With the headache, if you have any vertigo symptoms, you might consider adding B6.
Mino can cause vertigo and other vestibular problems for some and B6 might offset that.
Here's a little more about that:
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excerpts:
. . . In all the 40 test persons it could be proved that the amount of vertigo and nausea symptoms was increased significantly due to the application of minocycline only.
. . . However, when combining minocycline with vitamin B 6, the vertigo and nausea symptoms as well as the nystagmus signs . . . were remarkably reduced . . . .
ANTIVERTIGINOUS ACTION OF B-6 ON EXPERIMENTAL MINOCYLINE-INDUCED VERTIGO IN MAN
[Article in German]
Claussen CF, Claussen E. Neurootologie, Universit�ts-HNO-Klinik W�rzburg.
By means of a former investigation it has been proved equilibriometrically that the application of 7 X 100 mg minocycline may induce a central equilibrium dysregulation of the brainstem type.
It was the purpose of this study to further assure that the minocycline induced brainstem vertigo is due to a destabilization of a supervisory gamma-aminobutyric acid (GABA)ergic loop from the archeocerebellum upon the pontomedullary vestibular regulating pathways.
As it is pharmacologically known that pyridoxine is essential for the synthesis of GABA, an inhibitory CNS neurotransmitter, 2 separate double blind trials on 20 healthy young persons each were carried out after the intake of 7 X 100 mg minocycline during 3 days with and without 7 X 40 mg pyridoxine simultaneously.
These trials were checked against an additional placebo or initial non drug investigation.
In all the 40 test persons it could be proved that the amount of vertigo and nausea symptoms was increased significantly due to the application of minocycline only.
However, when combining minocycline with vitamin B 6, the vertigo and nausea symptoms as well as the nystagmus signs from the monaural and the binaural vestibular ocular tests as well as the vestibular spinal signs from the craniocorpography recordings of the stepping and the standing procedures were remarkably reduced.
There were no statistical differences between the initial or placebo trials versus the trials with a combination of minocycline with vitamin B 6.
The same holds for the vestibular vegetative reactions, measured by the simultaneous electrocardiography during the vestibular tests.
All the equilibriometric tests applied showed a significant destabilization under the influence of a pure minocycline loading.
(ABSTRACT TRUNCATED AT 250 WORDS)
UTPMID: 3382463 [PubMed - indexed for MEDLINE]
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Posted by nancysilverspring (Member # 16204) on :
Have these studies shown the side-effects such as vertigo to be permanent, or temporary while using minocycline? Thank you for your information.
Posted by nancysilverspring (Member # 16204) on :
How long before symptoms start to go away? I am getting worried. I can't do anything right now.
Posted by abigail (Member # 14936) on :
I took minocycline 200 mg twice a day for months. Might have slowed it down a bit but that's it. I'm on plaquenil and biaxin now. Still isn't killing it but keeps it very, very quiet. I'm hoping once I get on heparin, the antibiotics will be more effective.
Posted by kelmo (Member # 8797) on :
My daughter had the most improvement on mino, but now has leveled out. We are just staying the course for a little while longer, and adding an anti-malarial.
Starting out full dose may have hit you hard. I had to cut my daughter's mino in half (I bought the empty capsules and divided the powder). So, she could only do 50mg twice weekly, then work up to 200mg daily.
So, you may be having a herx or flare from starting a new drug.
Posted by mazou (Member # 15319) on :
I started with two per day, without food, and was knocked out by the vertigo. I cut down to one per day for one week (with food) then went back to two (with food).
Finally, in week three I was able to tolerate 2x a day on an empty stomach. But it is really strong, so take it easy.
Posted by Cobweb (Member # 10053) on :
TWO WEEKS?!
I was told when I asked ,that I might start feeling better after SIX MONTHS.
However, it was not until after 8 months of IV that I started to feel better-and I didn't start the IV until after a year of orals.
BTW-I chose the nausea of Doxy over the vertigo of Mino when on orals.
Now I'm just on oral Rifampin for Bart-and I'm finally beginning to feel like I have arrived at the end of the tunnel-after ONE HUNDRED AND TWENTY NINE WEEKS.
Don't get discouraged-it's worth the weight, I mean wait.
Posted by hcconn22 (Member # 5263) on :
Mino by itself is not the most common Lyme treatment. Lyme can take several forms and can evade antibiotics. Thats why many LLMD's use combinations of abx for treatments.
Also many do feel worse after taking abx for a while.
Did you have a positive test for Lyme- just curious.
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