LymeNet Flash: Did Malarone make anyone else really fatigued??

This is topic Did Malarone make anyone else really fatigued?? in forum Medical Questions at LymeNet Flash.

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Posted by kitkat32 (Member # 9682) on :

I didn't see this listed as a side effect. I was taking it in the A.M. and I couldn't stay awake.

I thought it was a herx reaction and then I switched to taking it in the evening. Last night I was so tired and got an instant migraine.

Anyone else have this problem with Malarone?

Thanks, kit

Posted by lymielauren28 (Member # 13742) on :

YES!! fatigue has always been one of my worst symptoms, but since starting malarone 6 weeks ago I am so tired I can barely function...

I am also having episodes of severe air hunger, which I NEVER had before - my guess is that it's a die-off reaction...

Lauren

Posted by sixgoofykids (Member # 11141) on :

Sounds like a herx to me. I do not get the fatigue from the Malarone, but my babs has been being treated for 18 months.

The air hunger definitely sounds like a herx reaction!

I'd mention it to your LLMD at your next appt, or sooner if you continue to get a migraine from it.

Posted by bestblondemom (Member # 14103) on :

I have been on maralone twice and both times I got terrible fatige. I will not take it again.

Posted by Rianna (Member # 11038) on :

For me it was an instant relief, I take 3 pills with breakfast and I literally went from chronically depressed and no mobility to normal and mobile within 48 hours of starting Malarone.

I am still astounded as its been a miracle drug for me and so far the best response I have ever had with any drug.

Rianna

Posted by Bugg (Member # 8095) on :

KitKat--

I assume you've stopped your CoQ10 to take Malarone? Is that right?

Posted by Lymetoo (Member # 743) on :

Definitely a herx. Babesia causes extreme fatigue. If you're feeling more fatigued than usual, that is pretty normal for babs treatment!!!

Hope you feel better soon! [Smile]

Posted by Bugg (Member # 8095) on :

Malarone inhibits mitochondrial electron transport in the protozoa. Of course this is going to impact your mitochondrial function within your other cells, thus impacting your ATP and causing you to feel fatigued. You'll need to resume CoQ10 as soon as you cease your course of Malarone.

Posted by Rianna (Member # 11038) on :

I am on malarone and have never taken Q10 as I cannot take it, I beleive that I do not have the fatigue as I am also on T3 and Ribose both of which increases the cellular ATP level.

Again not everyone's the same as I have no fatigue on Malarone and in fact since being on it have far more energy.

Riana

Posted by njgirl14 (Member # 14174) on :

hat other abx or supplements should you NOT take with Malarone?

It was stated in another thread that Doxy lowers Mepron's effectiveness by 40%. Is the same true of Malarone with Doxy?

Posted by Rianna (Member # 11038) on :

[QUOTE]Originally posted by njgirl14:
[QB] hat other abx or supplements should you NOT take with Malarone?

Malarone is atovaquone & proguanil an interacts strongly with

Rifabutin (e.g., Mycobutin) or Rifampin (e.g., Rifadin)--Use of rifampin may decrease the amount of atovaquone in the blood and keep it from working properly

Metoclopramide (e.g., Reglan)--Use of metoclopramide with atovaquone and proguanil may lessen the amount of atovaquone your body absorbs

Tetracycline (e.g., Sumycin)--Use of tetracycline lowers the amount of atovaquone in your blood.

Also.....

Atovaquone is known to interact with the following drugs:

Moderate Interactions
Ala-Tet, Arava, ARI Sodium Iodide (I123) 1-12 MBq, ARI Sodium Iodide (I123) 100-750 MBq, Avonex, Avonex Prefilled Syringe, Betaseron, Brodspec, clofarabine, Clolar, Crixivan, echinacea, Emtet-500, Etopophos, etoposide, etoposide phosphate, Folex PFS, indinavir, interferon beta-1a, interferon beta-1b, Iodotope, leflunomide, methotrexate, Methotrexate Sodium, Preservative Free, metoclopramide, Mycobutin, naltrexone, Panmycin, Priftin, Rebif, Reglan, ReVia, Rheumatrex Dose Pack, rifabutin, Rifadin, Rifadin IV, rifampin, rifapentine, Rimactane, Robitet 500, sodium iodide I-123, sodium iodide-I-131, Sumycin, Tetracap, Tetracon, tetracycline, thioguanine, Toposar, Trexall, typhoid vaccine, live, VePesid, Vivitrol, Vivotif Berna

Minor Interactions
AZT, ddI, didanosine, didanosine delayed release capsule, Gantanol, Primsol, Proloprim, Retrovir, sulfamethoxazole, TMP, trimethoprim, Trimpex, Videx, Videx EC, zidovudine

Proguanil is known to interact with the following drugs:

Major Interactions
auranofin, Aurolate, aurothioglucose, gold sodium thiomalate, Myochrysine, Ridaura, Solganal

Moderate Interactions
Accupril, Alka-Mints, Alkets, Alkums, Aloh-Gel, Alternagel, Alu-Cap, Alu-Tab, aluminum hydroxide, Amilac, Amitone, Amphojel, anisindione, ARI Sodium Iodide (I123) 1-12 MBq, ARI Sodium Iodide (I123) 100-750 MBq, armodafinil, Cal Oys, Cal-Gest, Calcarb, Calci Mix, Calci-Chew, Calcitab, calcium carbonate, Calcium Concentrate, Calcium Liquid Softgel, Calcium Oyster, Calcium Oyster Shell, Caltrate, Caltro, Chooz, cloxacillin, Cloxapen, Concentrated Phillips Milk of Magnesia, Coumadin, Daraprim, Dialume, Dicarbosil, dicumarol, Equilet, Ex-Lax Milk of Magnesia, Extra Strength Mylanta Calci Tabs, Icar Prenatal Chewable Calcium, Iodotope, Jantoven, kaolin, Losospan, Lowsium, Maalox Antacid Barrier, Maalox Childrens', Maalox Quick Dissolve, Maalox Quick Dissolve Extra Strength, Maalox Quick Dissolve Maximum Strength, Maalox Regular Strength, magaldrate, magnesium hydroxide, magnesium trisilicate, Maoson, Mg hydroxide, Milk of Magnesia, Miradon, modafinil, Mylanta Child, Nephro Calci, Neut, Nuvigil, Os-Cal, Os-Cal 500, Oysco 500, Oyst Cal, Oyst Cal 500, Oyster, Oyster Cal, Oyster Cal 500, Oyster Calcium, Oyster Shell, oyster shell calcium, Oyster Shell Calcium 500, Pepto Children's, Phillips Milk of Magnesia, Provigil, pyrimethamine, quinapril, Ri-Mag, Riopan, Rolaids Sodium Free, Rolaids Soft Chew, Ron Acid, sodium bicarbonate, sodium iodide I-123, sodium iodide-I-131, Super Calcium, Surpass, Surpass Extra Strength, Titralac, Tums, Tums 500, Tums E-X, Tums Extra Strength, Tums Ultra, typhoid vaccine, live, Ultra Mylanta Calci Tabs, Vivotif Berna, warfarin

Minor Interactions
Aczone, bortezomib, dapsone topical, Velcade

Posted by njgirl14 (Member # 14174) on :

Thanks Rianna

I did not see Doxy on the list. Any comments???

Posted by Littlesprout (Member # 7406) on :

My first nite with Malarone was terrible
(1/2 tab) I almost passed out on the toliet. Had to hold on to the walls, nausea, sweating, dizzy. My LLMD said there are a few people who can't take Malarone. I never tried it again.

Posted by Rianna (Member # 11038) on :

quote:
Originally posted by njgirl14:
Thanks Rianna I did not see Doxy on the list. Any comments???

It does state not to take tetracyclines so that would mean Doxy I assume as doxycycline is a member of the tetracycline antibiotics group

Examples of tetracyclines

Tetracycline
Chlortetracycline
Oxytetracycline
Demeclocycline
Doxycycline
Lymecycline
Meclocycline
Methacycline
Minocycline
Rolitetracycline

Posted by benwa29 (Member # 51515) on :

I have the exact same problem. Wired need for fresh air, very bad training resistance, fatigue and muscle fatigue. I hate malarone! [Smile]

When I took it I dont remember right. But I have had so heavy muscle fatigue... it was very hard to climb the steps above.

I dont remeber exactly. But, yes. Heavy derealization. And things like that.

quote:
Originally posted by lymielauren28:
YES!! fatigue has always been one of my worst symptoms, but since starting malarone 6 weeks ago I am so tired I can barely function...

I am also having episodes of severe air hunger, which I NEVER had before - my guess is that it's a die-off reaction...

Lauren