This is topic HELP! - just took 100mg minocycline 1st time in forum Medical Questions at LymeNet Flash.


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Posted by Nobody (Member # 16041) on :
 
like 10 minutes later, feeling very lightheaded, dizzy, weak all over, shaky, eye twitching, feet vibrating...

What should I do?

[Frown]
 
Posted by treepatrol (Member # 4117) on :
 
Stay upright dont lay down at least 1 hr situp.
Drink some more water and if you can eat something it will slow absorbtion.
Hang in there oh if there is anyone around tell them what your on and if they can have them come sit with you that way if something did happen they could get you help.
I doubt anything will happen other than a herx or upset tummy thouh. Better to error on caution.
 
Posted by lymielauren28 (Member # 13742) on :
 
Hey Nobody,

I can't tell you if what you're experiencing is a herx or not, but I can tell you that Minocycline hits me like a ton of bricks every time I take it.

Within a half an hour I begin to herx and it's a neuro herx...different from all the rest with other abx.

My guess is that this is what you're experiencing. I feel for you because I know what a powerful punch that stuff packs.

Hang in there, remeber it's doing it's job and I hope you feel better soon.

[group hug] Lauren
 
Posted by ticked-offinNc (Member # 15420) on :
 
Most people have dizziness as a side effect, it goes away though. I hope you feel better. Also, take it with food, so it is absorbed more slowly
 
Posted by disturbedme (Member # 12346) on :
 
I HATE Mino. It's the only abx that gave me neck stiffness and upper back pain/uncomfortableness. I can't stand that symptom either. It's one of the worst symptoms, for sure. It hurts to sit, hurts to lay, etc.
 
Posted by feelfit (Member # 12770) on :
 
Sorry about how you are feeling Nobody!

Oh boy, I am sitting here looking at my Mino bottle and wondering if i really want to take this med.

Feelfit
 
Posted by FunkOdyssey (Member # 15855) on :
 
quote:
Oh boy, I am sitting here looking at my Mino bottle and wondering if i really want to take this med.
You do, because that medication is second to none for CNS penetration and, aside from its documented side effects, any additional unpleasantness you feel is likely the fallout of its bacteria killing action.
 
Posted by dguy (Member # 8979) on :
 
sounds like herx

high doses of benicar are reportd to ease bad herxes

if your herx is intolerable, you might consider reducing your mino dose... it took me many weeks to build up to 100 mg
 
Posted by Nobody (Member # 16041) on :
 
Thanks everyone. It was worse earlier when I first took the mino, but its not as bad now. Looking at the computer screen seems to increase the lightheadedness / dizziness.

Maybe I will only take one every other day for now, just to ease in to it. The pills are 100mg each, so unless I open the capsule, there's no way to take less, and don't they irritate the esophagus that way?

Question - would this drug do this to a person without lyme?? It certainly hits you hard!
[dizzy]
 
Posted by Keebler (Member # 12673) on :
 
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Yes, this can have some of the same effects (esp. vertigo) in others. And - B6 may help. NAC, too.


http://tinyurl.com/47xrjn

Arzneimittelforschung. 1988 Mar;38(3):396-9.


ANTIVERTIGINOUS ACTION OF B-6 ON EXPERIMENTAL MINOCYLINE-INDUCED VERTIGO IN MANn


Claussen CF, Claussen E.- -Neurootologie, Universit�ts-HNO-Klinik W�rzburg.


By means of a former investigation it has been proved equilibriometrically that the application of 7 X 100 mg minocycline may induce a central equilibrium dysregulation of the brainstem type.


It was the purpose of this study to further assure that the minocycline induced brainstem vertigo is due to a destabilization of a supervisory gamma-aminobutyric acid (GABA)ergic loop from the archeocerebellum upon the pontomedullary vestibular regulating pathways.


As it is pharmacologically known that pyridoxine is essential for the synthesis of GABA, an inhibitory CNS neurotransmitter, 2 separate double blind trials on 20 healthy young persons each were carried out after the intake of 7 X 100 mg minocycline during 3 days with and without 7 X 40 mg pyridoxine simultaneously.


These trials were checked against an additional placebo or initial non drug investigation. In all the 40 test persons it could be proved that the amount of vertigo and nausea symptoms was increased significantly due to the application of minocycline only.


*** However, when combining minocycline with vitamin B 6, the vertigo and nausea symptoms as well as the nystagmus signs from the monaural and the binaural vestibular ocular tests as well as the vestibular spinal signs from the craniocorpography recordings of the stepping and the standing procedures were remarkably reduced. ***

. . .

The same holds for the vestibular vegetative reactions, measured by the simultaneous electrocardiography during the vestibular tests.


All the equilibriometric tests applied showed a significant destabilization under the influence of a pure minocycline loading.


(ABSTRACT TRUNCATED AT 250 WORDS)

UTPMID: 3382463 [PubMed - indexed for MEDLINE]


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Posted by brooke (Member # 16606) on :
 
You could ask your doctor for 50 mg pills. I've been taking those every other day for 4 weeks. Then she'll probably have me take 50 mgs every day and then 100 mgs every other day. I would rather go slow than have to quit because it was too much.

brooke
 
Posted by Keebler (Member # 12673) on :
 
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The Road Back Foundation at www.roadback.org may be a place to see what helps others. I talked to someone there a while back and they said that the pelleted, time-released MINOCIN was easier for some.


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Posted by TerryK (Member # 8552) on :
 
Please call your doctor and let them know of your symptoms.

Terry
 


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